Lactylation: a Passing Fad or the Future of Posttranslational Modification

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours

(2021) Roberta Zappasodi et al.   NATURE

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Histone demethylase KDM2A: Biological functions and clinical values (Review)

(2021) Lisheng Liu et al.   Experimental and Therapeutic Medicine

ARRB1 Regulates Metabolic Reprogramming to Promote Glycolysis in Stem Cell-Like Bladder Cancer Cells

(2021) Kenza Mamouni et al.   Cancers

The Biological Significance of Targeting Acetylation-Mediated Gene Regulation for Designing New Mechanistic Tools and Potential Therapeutics

(2021) Chenise O’Garro et al.   Biomolecules

Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis

(2021) Kun Yang et al.   CELL DEATH AND DIFFERENTIATION

Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells

(2021) Yong-Soo Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Pre-and Post-Transplant Serum Lactate Dehydrogenase Levels as a Predictive Marker for Patient Survival and Engraftment in Allogeneic Hematopoietic Stem Cell Transplant Recipients

(2021) Elham Roshandel et al.   Reports of Biochemistry and Molecular Biology

Histone lactylation: epigenetic mark of glycolytic switch

(2021) Xiaofeng Dai et al.   TRENDS IN GENETICS

Protein lactylation induced by neural excitation

(2021) Hideo Hagihara et al.   Cell Reports

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

(2020) Ming He et al.   Cell Metabolism

Compartmentalized acyl-CoA metabolism and roles in chromatin regulation

(2020) Sophie Trefely et al.   Molecular Metabolism

Lactate as a fulcrum of metabolism

(2020) George A. Brooks   Redox Biology

Metabolic ink lactate modulates epigenomic landscape: A concerted role of pro-tumor microenvironment and macroenvironment during carcinogenesis

(2020) Nilesh Kumar Sharma et al.   CURRENT MOLECULAR MEDICINE

Metabolites Regulate Cell Signaling and Growth via Covalent Modification of Proteins

(2020) Gianluca Figlia et al.   DEVELOPMENTAL CELL

Lung Myofibroblast Promote Macrophage Pro-fibrotic Activity Through Lactate-induced Histone Lactylation

(2020) Huachun Cui et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Enolase 1 regulates stem cell-like properties in gastric cancer cells by stimulating glycolysis

(2020) Ting Yang et al.   Cell Death & Disease

Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues

(2020) Erika L. Varner et al.   Open Biology

Systematic Analysis of Lysine Lactylation in the Plant Fungal Pathogen Botrytis cinerea

(2020) Mingming Gao et al.   Frontiers in Microbiology

Modification of Proteins by Metabolites in Immunity

(2020) C. Diskin et al.   IMMUNITY

TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation

(2020) Ricardo A. Irizarry-Caro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications

(2020) Youbo Zhao et al.   Cell Reports

Malonylation of GAPDH is an inflammatory signal in macrophages

(2019) Silvia Galván-Peña et al.   Nature Communications

Glycolysis Regulates Human Embryonic Stem Cell Self-Renewal under Hypoxia through HIF-2α and the Glycolytic Sensors CTBPs

(2019) Sophie A. Arthur et al.   Stem Cell Reports

Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

(2019) Jiang Dai et al.   CELL

Screening, expression, purification and characterization of CoA-transferases for lactoyl-CoA generation

(2019) Xiaoxia Zhang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

(2019) Weina Zhang et al.   CELL

L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis

(2019) Kamel S. Kamel et al.   KIDNEY INTERNATIONAL

Histone lactylation links metabolism and gene regulation

(2019) Luke T. Izzo et al.   NATURE

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

(2019) Tushar D Bhagat et al.   eLife

Microbial carcinogenesis: Lactic acid bacteria in gastric cancer

(2019) Karla Vinasco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Sweet Temptation: From Sugar Metabolism to Gene Regulation

(2019) Giulia Notarangelo et al.   IMMUNITY

Metabolic heterogeneity confers differences in melanoma metastatic potential

(2019) Alpaslan Tasdogan et al.   NATURE

Lactate/GPR81 signaling and proton motive force in cancer: Role in angiogenesis, immune escape, nutrition, and Warburg phenomenon

(2019) Timothy P. Brown et al.   PHARMACOLOGY & THERAPEUTICS

Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses

(2018) Maria G. Daskalaki et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting epigenetic DNA and histone modifications to treat kidney disease

(2018) Miguel Fontecha-Barriuso et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α–mediated tumor progression

(2018) Na Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages

(2018) Toszka Bohn et al.   NATURE IMMUNOLOGY

The many lives of KATs — detectors, integrators and modulators of the cellular environment

(2018) Bilal N. Sheikh et al.   NATURE REVIEWS GENETICS

Arginine methylation regulates c-Myc–dependent transcription by altering promoter recruitment of the acetyltransferase p300

(2017) Irina Tikhanovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation

(2017) Li Ma et al.   MOLECULAR CELL

DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway

(2017) V I Alexaki et al.   MOLECULAR PSYCHIATRY

Lactic Acid: No Longer an Inert and End-Product of Glycolysis

(2017) Shiren Sun et al.   PHYSIOLOGY

Non-enzymatic N -acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S -acetylated Thiol Intermediate Sensitive to Glyoxalase II

(2017) Andrew M. James et al.   Cell Reports

SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice

(2017) Fang Wang et al.   Cell Reports

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Enhancement of Hypothalamic STAT3 Acetylation by Nuclear Receptor Nur77 Dictates Leptin Sensitivity

(2015) Yan Chen et al.   DIABETES

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease

(2013) Y Tang et al.   CELL DEATH AND DIFFERENTIATION

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation

(2011) S. E. Mullican et al.   GENES & DEVELOPMENT

Blood lactate as a predictor for in-hospital mortality in patients admitted acutely to hospital: a systematic review

(2011) Ole Kruse et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Hypoxia-mediated biological control

(2010) Jessica Cassavaugh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation

(2009) Kelly M Kennedy et al.   Future Oncology

Cell-cell and intracellular lactate shuttles

(2009) George A. Brooks   JOURNAL OF PHYSIOLOGY-LONDON

Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81

(2008) Changlu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY