Lactic Acid: No Longer an Inert and End-Product of Glycolysis

Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease

(2016) RS Jones et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Multislice CEST MRI improves the spatial assessment of tumor pH

(2016) Edward A. Randtke et al.   MAGNETIC RESONANCE IN MEDICINE

Lactate, a Neglected Factor for Diabetes and Cancer Interaction

(2016) Yong Wu et al.   MEDIATORS OF INFLAMMATION

Probe for the measurement of cell surface pH in vivo and ex vivo

(2016) Michael Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4

(2016) Candice Sun Hong et al.   Cell Reports

Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model

(2016) Carolina Iraporda et al.   Frontiers in Immunology

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner

(2016) Agustina Errea et al.   PLoS One

Lactic acid delays the inflammatory response of human monocytes

(2015) Katrin Peter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells

(2015) Ricardo Amorim et al.   CANCER LETTERS

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells

(2015) Carolina Iraporda et al.   IMMUNOBIOLOGY

Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons

(2015) Giorgio Santoni et al.   Journal of Neuroinflammation

A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy

(2015) Nelma Pertega-Gomes et al.   JOURNAL OF PATHOLOGY

Combined effects of PLGA and vascular endothelial growth factor promote the healing of non-diabetic and diabetic wounds

(2015) Kiran Kumar Chereddy et al.   Nanomedicine-Nanotechnology Biology and Medicine

Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function

(2015) Somayeh Jamali et al.   Scientific Reports

Activation of N-methyl-d-aspartate receptor downregulates inflammasome activity and liver inflammation via a β-arrestin-2 pathway

(2014) Ahmad Farooq et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival

(2014) C. L. Roland et al.   CANCER RESEARCH

Aerobic Glycolysis in the Human Brain Is Associated with Development and Neotenous Gene Expression

(2014) Manu S. Goyal et al.   Cell Metabolism

Inhibition of G Protein-Coupled Receptor 81 (GPR81) Protects Against Ischemic Brain Injury

(2014) Zhe Shen et al.   CNS Neuroscience & Therapeutics

Identification of a novel GPR81-selective agonist that suppresses lipolysis in mice without cutaneous flushing

(2014) Taku Sakurai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

(2014) Rafaz Hoque et al.   GASTROENTEROLOGY

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

(2014) A. Caro-Maldonado et al.   JOURNAL OF IMMUNOLOGY

Randomized Trial of [131I] Metuximab in Treatment of Hepatocellular Carcinoma After Percutaneous Radiofrequency Ablation

(2014) Huijie Bian et al.   JNCI-Journal of the National Cancer Institute

Antitumor Activity of 7-Aminocarboxycoumarin Derivatives, a New Class of Potent Inhibitors of Lactate Influx but Not Efflux

(2014) N. Draoui et al.   MOLECULAR CANCER THERAPEUTICS

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Lactic Acidosis

(2014) Jeffrey A. Kraut et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Influences That Regulate Dendritic Cell Function in Tumors

(2014) Han Dong et al.   Frontiers in Immunology

Astrocyte regulation of cerebral vascular tone

(2013) Jessica A. Filosa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The role of proton dynamics in the development and maintenance of multidrug resistance in cancer

(2013) Chloë Daniel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

(2013) K. H. Lauritzen et al.   CEREBRAL CORTEX

Dendritic Cell Reprogramming by Endogenously Produced Lactic Acid

(2013) A. Nasi et al.   JOURNAL OF IMMUNOLOGY

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

The SLC16 gene family – Structure, role and regulation in health and disease

(2013) Andrew P. Halestrap   MOLECULAR ASPECTS OF MEDICINE

Metabolic signaling by lactate in the brain

(2013) L. Felipe Barros   TRENDS IN NEUROSCIENCES

131I-labeled metuximab combined with chemoembolization for unresectable hepatocellular carcinoma

(2013) Qing He   WORLD JOURNAL OF GASTROENTEROLOGY

Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice

(2012) Paolo E. Porporato et al.   ANGIOGENESIS

Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments

(2012) Jonathan W. Wojtkowiak et al.   CANCER RESEARCH

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

Role of Leaky Neuronal Ryanodine Receptors in Stress- Induced Cognitive Dysfunction

(2012) Xiaoping Liu et al.   CELL

Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth,Angiogenesis and Metastasis

(2012) Suveera Dhup et al.   CURRENT PHARMACEUTICAL DESIGN

Hepatic artery injection of 131I-labelled metuximab combined with chemoembolization for intermediate hepatocellular carcinoma: a prospective nonrandomized study

(2012) Lu Wu et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model

(2012) Nicola J. Robertson et al.   JOURNAL OF NEUROCHEMISTRY

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells

(2012) Christophe J. De Saedeleer et al.   PLoS One

Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects

(2012) Curt A. Dvorak et al.   ACS Medicinal Chemistry Letters

Potential Role of NHE1 (Sodium-Hydrogen Exchanger 1) in the Cellular Dysfunction of Lactic Acidosis: Implications for Treatment

(2011) Dongmei Wu et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation

(2011) Anna N. Mendler et al.   INTERNATIONAL JOURNAL OF CANCER

The monocarboxylate transporter family-Structure and functional characterization

(2011) Andrew P. Halestrap   IUBMB LIFE

Brain Lactate Metabolism: The Discoveries and the Controversies

(2011) Gerald A Dienel   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuronal basis of age-related working memory decline

(2011) Min Wang et al.   NATURE

Extraordinary neoteny of synaptic spines in the human prefrontal cortex

(2011) Zdravko Petanjek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein

(2010) Matthew J. Ovens et al.   BIOCHEMICAL JOURNAL

Adipose Tissue Lipolysis Revisited (Again!): Lactate Involvement in Insulin Antilipolytic Action

(2010) Dominique Langin   Cell Metabolism

An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81

(2010) Kashan Ahmed et al.   Cell Metabolism

Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression

(2010) Hongmin Chen et al.   CLINICAL & EXPERIMENTAL METASTASIS

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models

(2009) W Schneiderhan et al.   GUT

Studies on the DIDS-binding Site of Monocarboxylate Transporter 1 Suggest a Homology Model of the Open Conformation and a Plausible Translocation Cycle

(2009) Marieangela C. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-cell and intracellular lactate shuttles

(2009) George A. Brooks   JOURNAL OF PHYSIOLOGY-LONDON

Role of GPR81 in lactate-mediated reduction of adipose lipolysis

(2008) Tian-Quan Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acid treatment of melanoma cells selects for invasive phenotypes

(2008) Raymond E. Moellering et al.   CLINICAL & EXPERIMENTAL METASTASIS

Gene inactivation of Na+/H+exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemia

(2008) Yanping Wang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81

(2008) Changlu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidation of signaling and functional activities of an orphan GPCR, GPR81

(2008) Hongfei Ge et al.   JOURNAL OF LIPID RESEARCH

Brain metabolism dictates the polarity of astrocyte control over arterioles

(2008) Grant R. J. Gordon et al.   NATURE

Macrophage polarization in tumour progression

(2008) Antonio Sica et al.   SEMINARS IN CANCER BIOLOGY