Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages

Metabolic origins of spatial organization in the tumor microenvironment

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Serum lactate dehydrogenase as an early marker for outcome in patients treated with anti-PD-1 therapy in metastatic melanoma

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LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab

(2016) Benjamin Weide et al.   CLINICAL CANCER RESEARCH

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance

(2016) Susana Romero-Garcia et al.   Frontiers in Immunology

Metabolic communication in tumors: a new layer of immunoregulation for immune evasion

(2016) Ping-Chih Ho et al.   Journal for ImmunoTherapy of Cancer

Prognostic role of lactate dehydrogenase in solid tumors: A systematic review and meta-analysis of 76 studies

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Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane

(2015) Mehdi Damaghi et al.   Nature Communications

TNF Counterbalances the Emergence of M2 Tumor Macrophages

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Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway

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Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

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Nivolumab plus Ipilimumab in Advanced Melanoma

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Acidic tumor microenvironment and pH-sensing G protein-coupled receptors

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STAR: ultrafast universal RNA-seq aligner

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Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

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Macrophage Diversity Enhances Tumor Progression and Metastasis

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

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High-Density Gene Expression Analysis of Tumor-Associated Macrophages from Mouse Mammary Tumors

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CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

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Final Version of 2009 AJCC Melanoma Staging and Classification

(2009) Charles M. Balch et al.   JOURNAL OF CLINICAL ONCOLOGY

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lactate Boosts TLR4 Signaling and NF- B Pathway-Mediated Gene Transcription in Macrophages via Monocarboxylate Transporters and MD-2 Up-Regulation

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Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

(2009) K. Dietl et al.   JOURNAL OF IMMUNOLOGY

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducible cAMP Early Repressor Acts as a Negative Regulator for Kindling Epileptogenesis and Long-Term Fear Memory

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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