Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells

Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

(2020) Eman Khatib-Massalha et al.   Nature Communications

Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling

(2020) Kun Yang et al.   Frontiers in Immunology

Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow

(2019) Stefano Comazzetto et al.   Cell Stem Cell

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

(2019) Smitha Krishnan et al.   Cell Reports

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss

(2018) Sébastien Lucas et al.   Nature Communications

The Gut Microbiome as a Major Regulator of the Gut-Skin Axis

(2018) Iman Salem et al.   Frontiers in Microbiology

Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration

(2018) Heather A. Himburg et al.   Cell Stem Cell

Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development

(2018) Yong-Soo Lee et al.   Cell Host & Microbe

The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression

(2018) Abdul Malik Tyagi et al.   IMMUNITY

Homeostatic Immunity and the Microbiota

(2017) Yasmine Belkaid et al.   IMMUNITY

Differential cytokine contributions of perivascular haematopoietic stem cell niches

(2017) Noboru Asada et al.   NATURE CELL BIOLOGY

The Promotion of Erythropoiesis via the Regulation of Reactive Oxygen Species by Lactic Acid

(2017) Shun-Tao Luo et al.   Scientific Reports

Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis

(2016) C. B. Hergott et al.   BLOOD

Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis

(2016) Chiaki Iwamura et al.   BLOOD

Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota

(2016) Kamilla S. Josefsdottir et al.   BLOOD

Gut-Pancreatic Axis AMPlified in Islets of Langerhans

(2015) Stacy H. Ryu et al.   IMMUNITY

Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota

(2015) Jia Sun et al.   IMMUNITY

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

(2015) Melih Acar et al.   NATURE

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection

(2014) Arya Khosravi et al.   Cell Host & Microbe

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

Microbiota-Derived Compounds Drive Steady-State Granulopoiesis via MyD88/TICAM Signaling

(2014) Maria L. Balmer et al.   JOURNAL OF IMMUNOLOGY

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

(2014) Da Young Oh et al.   NATURE MEDICINE

SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors

(2013) Hideyuki Oguro et al.   Cell Stem Cell

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche

(2012) Ryohichi Sugimura et al.   CELL

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Commensal bacteria–derived signals regulate basophil hematopoiesis and allergic inflammation

(2012) David A Hill et al.   NATURE MEDICINE

Chronic IFN-  production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis

(2011) S. F. Libregts et al.   BLOOD

Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands

(2011) Chao Shi et al.   IMMUNITY

Bifidobacteria can protect from enteropathogenic infection through production of acetate

(2011) Shinji Fukuda et al.   NATURE

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Role of GPR81 in lactate-mediated reduction of adipose lipolysis

(2008) Tian-Quan Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81

(2008) Changlu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidation of signaling and functional activities of an orphan GPCR, GPR81

(2008) Hongfei Ge et al.   JOURNAL OF LIPID RESEARCH