The Biological Significance of Targeting Acetylation-Mediated Gene Regulation for Designing New Mechanistic Tools and Potential Therapeutics

Targeting p300/CBP axis in lethal prostate cancer

(2021) Jonathan Welti et al.   Cancer Discovery

Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis

(2021) Adeline Rosu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PCAF ‐mediated acetylation of ISX recruits BRD 4 to promote epithelial‐mesenchymal transition

(2020) Li‐Ting Wang et al.   EMBO REPORTS

What will neXtProt help us achieve in 2020 and beyond?

(2020) Monique Zahn-Zabal et al.   Expert Review of Proteomics

Early Drug Discovery Efforts Towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors

(2020) Jonathan Edward Wilson et al.   ChemMedChem

The key roles of the lysine acetyltransferases KAT6A and KAT6B in physiology and pathology

(2020) Naama Wiesel-Motiuk et al.   DRUG RESISTANCE UPDATES

Histone acetyltransferase 1 is a succinyltransferase for histones and non‐histones and promotes tumorigenesis

(2020) Guang Yang et al.   EMBO REPORTS

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

Epigenetic Enzyme Mutations: Role in Tumorigenesis and Molecular Inhibitors

(2019) Mei Han et al.   Frontiers in Oncology

An Overview of the Polymorphisms of Circadian Genes Associated With Endocrine Cancer

(2019) Sonia Morales-Santana et al.   Frontiers in Endocrinology

Kat6b Modulates Oct4 and Nanog Binding to Chromatin in Embryonic Stem Cells and Is Required for Efficient Neural Differentiation

(2019) María Soledad Cosentino et al.   JOURNAL OF MOLECULAR BIOLOGY

Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer

(2019) Ping Fan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ELP3 acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK)

(2019) Meng-Tian Li et al.   BIOCHEMICAL JOURNAL

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Genome-Editing Technologies: Concept, Pros, and Cons of Various Genome-Editing Techniques and Bioethical Concerns for Clinical Application

(2019) Sikandar Hayat Khan   Molecular Therapy-Nucleic Acids

Epigenetically Down-Regulated Acetyltransferase PCAF Increases the Resistance of Colorectal Cancer to 5-Fluorouracil

(2019) Tong Liu et al.   NEOPLASIA

PRC2 functions in development and congenital disorders

(2019) Orla Deevy et al.   DEVELOPMENT

C646 modulates inflammatory response and antibacterial activity of macrophage

(2019) Fang Fang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Make the right measurement: Discovery of an allosteric inhibition site for p300-HAT

(2019) Anna S. Gardberg et al.   Structural Dynamics-US

TAF1 plays a critical role in AML1-ETO driven leukemogenesis

(2019) Ye Xu et al.   Nature Communications

GCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways

(2019) Aimee T. Farria et al.   Oncotarget

HBO1 is required for the maintenance of leukaemia stem cells

(2019) Laura MacPherson et al.   NATURE

The prognostic capacities of CBP and p300 in locally advanced rectal cancer

(2019) Felix Rühlmann et al.   World Journal of Surgical Oncology

Histone acetylation of oligodendrocytes protects against white matter injury induced by inflammation and hypoxia-ischemia through activation of BDNF-TrkB signaling pathway in neonatal rats

(2018) Jichong Huang et al.   BRAIN RESEARCH

Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer

(2018) Alacoque L. Browne et al.   ONCOGENE

Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases

(2018) Michael R. Michaelides et al.   ACS Medicinal Chemistry Letters

A p300 and SIRT1 Regulated Acetylation Switch of C/EBPα Controls Mitochondrial Function

(2018) Mohamad A. Zaini et al.   Cell Reports

Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3

(2018) Adam Vincek et al.   MOLECULES

The many lives of KATs — detectors, integrators and modulators of the cellular environment

(2018) Bilal N. Sheikh et al.   NATURE REVIEWS GENETICS

Functions and mechanisms of non-histone protein acetylation

(2018) Takeo Narita et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Linking cellular stress responses to systemic homeostasis

(2018) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TIP60: an actor in acetylation of H3K4 and tumor development in breast cancer

(2018) Gaëlle Judes et al.   Epigenomics

SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma

(2018) Xianzhou Song et al.   CANCER LETTERS

Androgen Receptor Rearrangement and Splicing Variants in Resistance to Endocrine Therapies in Prostate Cancer

(2017) Yeung Ho et al.   ENDOCRINOLOGY

Histone acetyltransferase p300/CBP inhibitor C646 blocks the survival and invasion pathways of gastric cancer cell lines

(2017) Ya-Mei Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer

(2017) Manuel Viotti et al.   JOURNAL OF CELL BIOLOGY

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

(2017) Loren M. Lasko et al.   NATURE

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

(2017) Philipp Mews et al.   NATURE

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis

(2017) Binbin Lai et al.   NUCLEIC ACIDS RESEARCH

HAT1 induces lung cancer cell apoptosis via up regulating Fas

(2017) Na Han et al.   Oncotarget

Cellular Homeostasis and Aging

(2016) F. Ulrich Hartl   Annual Review of Biochemistry

Expression of the MOZ-TIF2 oncoprotein in mice represses senescence

(2016) Anne Largeot et al.   EXPERIMENTAL HEMATOLOGY

Functional analysis of HBO1 in tumor development and inhibitor screening

(2016) LING-LI GUO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

KAT5 (Tip60) is a potential therapeutic target in malignant pleural mesothelioma

(2016) SIAN CREGAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer

(2016) Sylvain Delaunay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein

(2016) Oleg Laptenko et al.   TRENDS IN BIOCHEMICAL SCIENCES

Clinical implications of the coexpression of SRC1 and NANOG in HER-2-overexpressing breast cancers

(2016) Bin Wang et al.   OncoTargets and Therapy

Epigenetic Determinants of Cancer

(2016) Stephen B. Baylin et al.   Cold Spring Harbor Perspectives in Biology

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer

(2016) Narsis Attar et al.   Cold Spring Harbor Perspectives in Medicine

Histone acetyltransferases: challenges in targeting bi-substrate enzymes

(2016) Hannah Wapenaar et al.   Clinical Epigenetics

NF-κB: Regulation by Methylation

(2015) Tao Lu et al.   CANCER RESEARCH

PRC2 mediated H3K27 methylations in cellular identity and cancer

(2015) Eric Conway et al.   CURRENT OPINION IN CELL BIOLOGY

Neuronal Kmt2a/Mll1 Histone Methyltransferase Is Essential for Prefrontal Synaptic Plasticity and Working Memory

(2015) M. Jakovcevski et al.   JOURNAL OF NEUROSCIENCE

Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug

(2015) Xianzhou Song et al.   PLoS One

Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs

(2015) Nasun Hah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Androgen receptor aberrations in the era of abiraterone and enzalutamide

(2015) Florian Jentzmik et al.   WORLD JOURNAL OF UROLOGY

A bivalent role of TIP60 histone acetyl transferase in human cancer

(2015) Gaëlle Judes et al.   Epigenomics

Human metabolic atlas: an online resource for human metabolism

(2015) Natapol Pornputtapong et al.   Database-The Journal of Biological Databases and Curation

The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis

(2015) Xiao-Jian Sun et al.   Frontiers in Oncology

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML)

(2015) Harald Herrmann et al.   Oncotarget

Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues

(2014) Jasna Maksimoska et al.   BIOCHEMISTRY

The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer

(2014) Zhiwei Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan

(2014) Tobias Eisenberg et al.   Cell Metabolism

CLOCK:BMAL1 is a pioneer-like transcription factor

(2014) J. S. Menet et al.   GENES & DEVELOPMENT

Coactivator MYST1 Regulates Nuclear Factor-κB and Androgen Receptor Functions During Proliferation of Prostate Cancer Cells

(2014) Anbalagan Jaganathan et al.   MOLECULAR ENDOCRINOLOGY

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Brd4 is on the move during inflammation

(2014) Yali Xu et al.   TRENDS IN CELL BIOLOGY

Writers and Readers of Histone Acetylation: Structure, Mechanism, and Inhibition

(2014) R. Marmorstein et al.   Cold Spring Harbor Perspectives in Biology

KAT6A, a Chromatin Modifier from the 8p11-p12 Amplicon is a Candidate Oncogene in Luminal Breast Cancer

(2014) Brittany Turner-Ivey et al.   NEOPLASIA

Targeting TBP-Associated Factors in Ovarian Cancer

(2014) Jennifer R. Ribeiro et al.   Frontiers in Oncology

Brd4 and JMJD6-Associated Anti-Pause Enhancers in Regulation of Transcriptional Pause Release

(2013) Wen Liu et al.   CELL

Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases

(2013) Frank J. Dekker et al.   DRUG DISCOVERY TODAY

Histone-modifying enzymes: their role in the pathogenesis of acute leukemia and their therapeutic potential

(2013) Ly P. Vu et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Nucleosome Remodeling and Epigenetics

(2013) P. B. Becker et al.   Cold Spring Harbor Perspectives in Biology

Histone H3K56 Acetylation, Rad52, and Non-DNA Repair Factors Control Double-Strand Break Repair Choice with the Sister Chromatid

(2013) Sandra Muñoz-Galván et al.   PLoS Genetics

Histone phosphorylation

(2012) Dorine Rossetto et al.   Epigenetics

neXtProt: Organizing Protein Knowledge in the Context of Human Proteome Projects

(2012) Pascale Gaudet et al.   JOURNAL OF PROTEOME RESEARCH

Histone Demethylase UTX and Chromatin Remodeler BRM Bind Directly to CBP and Modulate Acetylation of Histone H3 Lysine 27

(2012) F. Tie et al.   MOLECULAR AND CELLULAR BIOLOGY

Plk1 Phosphorylation of Orc2 and Hbo1 Contributes to Gemcitabine Resistance in Pancreatic Cancer

(2012) B. Song et al.   MOLECULAR CANCER THERAPEUTICS

The role of histone demethylases in cancer therapy

(2012) Inga Hoffmann et al.   Molecular Oncology

N-Myc and GCN5 Regulate Significantly Overlapping Transcriptional Programs in Neural Stem Cells

(2012) Verónica Martínez-Cerdeño et al.   PLoS One

The Protein Data Bank at 40: Reflecting on the Past to Prepare for the Future

(2012) Helen M. Berman et al.   STRUCTURE

Histone acetyltransferase 1: More than just an enzyme?

(2011) Mark R. Parthun   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

HOXC11–SRC-1 regulation of S100beta in cutaneous melanoma: new targets for the kinase inhibitor dasatinib

(2011) C deBlacam et al.   BRITISH JOURNAL OF CANCER

Global Characterization of the SRC-1 Transcriptome Identifies ADAM22 as an ER-Independent Mediator of Endocrine-Resistant Breast Cancer

(2011) D. McCartan et al.   CANCER RESEARCH

Metastatic Progression with Resistance to Aromatase Inhibitors Is Driven by the Steroid Receptor Coactivator SRC-1

(2011) J. McBryan et al.   CANCER RESEARCH

Rational Design of Cyclic Peptide Modulators of the Transcriptional Coactivator CBP: A New Class of p53 Inhibitors

(2011) Guillermo Gerona-Navarro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RelA Ser276 Phosphorylation-Coupled Lys310 Acetylation Controls Transcriptional Elongation of Inflammatory Cytokines in Respiratory Syncytial Virus Infection

(2011) A. R. Brasier et al.   JOURNAL OF VIROLOGY

The Histone Acetyltransferase hMOF is Overexpressed in Non-small Cell Lung Carcinoma

(2011) Joon Seon Song et al.   Korean Journal of Pathology

The RING Finger Protein MSL2 in the MOF Complex Is an E3 Ubiquitin Ligase for H2B K34 and Is Involved in Crosstalk with H3 K4 and K79 Methylation

(2011) Lipeng Wu et al.   MOLECULAR CELL

Hierarchies of NF-κB target-gene regulation

(2011) Stephen T Smale   NATURE IMMUNOLOGY

The biology of lysine acetylation integrates transcriptional programming and metabolism

(2011) Jigneshkumar Patel et al.   Nutrition & Metabolism

Interaction of Developmental Transcription Factor HOXC11 with Steroid Receptor Coactivator SRC-1 Mediates Resistance to Endocrine Therapy in Breast Cancer

(2010) M. McIlroy et al.   CANCER RESEARCH

Lysine methylation of promoter-bound transcription factors and relevance to cancer

(2010) George R Stark et al.   CELL RESEARCH

Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

(2010) Erin M. Bowers et al.   CHEMISTRY & BIOLOGY

Anti-viral opportunities during transcriptional activation of latent HIV in the host chromatin

(2010) Shiraz Mujtaba et al.   METHODS

MOF and Histone H4 Acetylation at Lysine 16 Are Critical for DNA Damage Response and Double-Strand Break Repair

(2010) G. G. Sharma et al.   MOLECULAR AND CELLULAR BIOLOGY

MOF and H4 K16 Acetylation Play Important Roles in DNA Damage Repair by Modulating Recruitment of DNA Damage Repair Protein Mdc1

(2010) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

A Role for SIRT1 in the Hypoxic Response

(2010) Scott F. Leiser et al.   MOLECULAR CELL

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

(2010) Kyoko L. Yap et al.   MOLECULAR CELL

TAF1 Differentially Enhances Androgen Receptor Transcriptional Activity via Its N-Terminal Kinase and Ubiquitin-Activating and -Conjugating Domains

(2010) Peyman Tavassoli et al.   MOLECULAR ENDOCRINOLOGY

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Chemical phylogenetics of histone deacetylases

(2010) James E Bradner et al.   Nature Chemical Biology

Valproate Administered after Traumatic Brain Injury Provides Neuroprotection and Improves Cognitive Function in Rats

(2010) Pramod K. Dash et al.   PLoS One

p53-Induced Growth Arrest Is Regulated by the Mitochondrial SirT3 Deacetylase

(2010) SiDe Li et al.   PLoS One

GCN5-dependent acetylation of HIV-1 integrase enhances viral integration

(2010) Mariaelena Terreni et al.   Retrovirology

Molecular Signals of Epigenetic States

(2010) Roberto Bonasio et al.   SCIENCE

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Consistent Deregulation of Gene Expression between Human and Murine MLL Rearrangement Leukemias

(2009) Z. Li et al.   CANCER RESEARCH

Histone acetyl transferases as emerging drug targets

(2009) Frank J. Dekker et al.   DRUG DISCOVERY TODAY

The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease

(2009) O. Gojis et al.   EJSO

Histone acetyltransferase Hbo1: Catalytic activity, cellular abundance, and links to primary cancers

(2009) Masayoshi Iizuka et al.   GENE

Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance

(2009) Boyko S. Atanassov et al.   MOLECULAR CELL

The role of SRC-3 in human breast cancer

(2009) Ondrej Gojis et al.   Nature Reviews Clinical Oncology

Epigenetic Silencing of MicroRNA miR-107 Regulates Cyclin-Dependent Kinase 6 Expression in Pancreatic Cancer

(2009) Kwang-Hyuck Lee et al.   PANCREATOLOGY

Tip60 promotes prostate cancer cell proliferation by translocation of androgen receptor into the nucleus

(2009) Masaki Shiota et al.   PROSTATE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Epigenetic regulation: methylation of histone and non-histone proteins

(2009) Fei Lan et al.   Science in China. Series C, Life sciences / Chinese Academy of Sciences

HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats

(2008) Bin Zhang et al.   BRAIN RESEARCH

Roles of the histone acetyltransferase monocytic leukemia zinc finger protein in normal and malignant hematopoiesis

(2008) Takuo Katsumoto et al.   CANCER SCIENCE

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Antibodypedia, a Portal for Sharing Antibody and Antigen Validation Data

(2008) Erik Björling et al.   MOLECULAR & CELLULAR PROTEOMICS

Molecular Architecture of Quartet MOZ/MORF Histone Acetyltransferase Complexes

(2008) M. Ullah et al.   MOLECULAR AND CELLULAR BIOLOGY

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

(2008) Xin Liu et al.   NATURE

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY

Structural insights into human KAP1 PHD finger–bromodomain and its role in gene silencing

(2008) Lei Zeng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Disentangling Mild Traumatic Brain Injury and Stress Reactions

(2008) Richard A. Bryant   NEW ENGLAND JOURNAL OF MEDICINE

SRC-3 Transcription-Coupled Activation, Degradation, and the Ubiquitin Clock: Is There Enough Coactivator to Go Around in Cells?

(2008) D. M. Lonard et al.   Science Signaling