Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses

Arginine methylation regulates c-Myc–dependent transcription by altering promoter recruitment of the acetyltransferase p300

(2017) Irina Tikhanovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation

(2017) Beixue Gao et al.   JOURNAL OF IMMUNOLOGY

Arginine Methylation: The Coming of Age

(2017) Roméo S. Blanc et al.   MOLECULAR CELL

New insights into the epigenetics of inflammatory rheumatic diseases

(2017) Esteban Ballestar et al.   Nature Reviews Rheumatology

HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function

(2017) Queping Liu et al.   Oncotarget

Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection

(2017) Rachel C. Moores et al.   Frontiers in Immunology

Role of Histone-Modifying Enzymes and Their Complexes in Regulation of Chromatin Biology

(2016) Renee DesJarlais et al.   BIOCHEMISTRY

The arginine methyltransferase PRMT5 regulates CIITA-dependent MHC II transcription

(2016) Zhiwen Fan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages

(2016) Konstantina Lyroni et al.   JOURNAL OF IMMUNOLOGY

SIRT1 inhibits differentiation of monocytes to macrophages: amelioration of synovial inflammation in rheumatoid arthritis

(2016) So Youn Park et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

ASF1a enhances antiviral immune response by associating with CBP to mediate acetylation of H3K56 at the Ifnb promoter

(2016) Zhaolong Liu et al.   MOLECULAR IMMUNOLOGY

MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection

(2016) Sahana Holla et al.   PLoS Pathogens

The HIF/PHF8/AR axis promotes prostate cancer progression

(2016) D Tong et al.   Oncogenesis

Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice

(2016) Xianfeng Wang et al.   PLoS One

Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation

(2016) Özgün Erdoğan et al.   Scientific Reports

Histone methylation modifiers in cellular signaling pathways

(2015) Hunain Alam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sirt-1 activity in PBMC from patients with spondyloarthritis

(2015) Daniel Wendling et al.   JOINT BONE SPINE

The Histone Methyltransferase Smyd2 Is a Negative Regulator of Macrophage Activation by Suppressing Interleukin 6 (IL-6) and Tumor Necrosis Factor α (TNF-α) Production

(2015) Guiliang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylase 5 regulates the inflammatory response of macrophages

(2015) Lukas Poralla et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Histone Lysine Methyltransferase Ezh1 Promotes TLR-Triggered Inflammatory Cytokine Production by Suppressing Tollip

(2015) Yiqi Liu et al.   JOURNAL OF IMMUNOLOGY

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs

(2015) Anthony J. Sadler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput screening to identify inhibitors of lysine demethylases

(2015) Molly Gale et al.   Epigenomics

The histone demethylase PHF8 is an oncogenic protein in human non-small cell lung cancer

(2014) Yuzhou Shen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting histone lysine demethylases — Progress, challenges, and the future

(2014) Cyrille C. Thinnes et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Macrophage polarization

(2014) Jan Van den Bossche et al.   CURRENT OPINION IN LIPIDOLOGY

Epigenetic Changes in Bone Marrow Progenitor Cells Influence the Inflammatory Phenotype and Alter Wound Healing in Type 2 Diabetes

(2014) Katherine A. Gallagher et al.   DIABETES

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

A novel histone deacetylase 6-selective inhibitor suppresses synovial inflammation and joint destruction in a collagen antibody-induced arthritis mouse model

(2014) Jaejoon Lee et al.   International Journal of Rheumatic Diseases

MRTF-A mediates LPS-induced pro-inflammatory transcription by interacting with the COMPASS complex

(2014) L. Yu et al.   JOURNAL OF CELL SCIENCE

Myeloid SIRT1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet

(2014) Sun-O Ka et al.   JOURNAL OF ENDOCRINOLOGY

Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells

(2014) Fengdong Cheng et al.   MOLECULAR IMMUNOLOGY

The Histone Demethylase PHF2 Promotes Fat Cell Differentiation as an Epigenetic Activator of Both C/EBPα and C/EBPδ

(2014) Kyoung-Hwa Lee et al.   MOLECULES AND CELLS

HIF-1-Dependent Induction of Jumonji Domain-Containing Protein (JMJD) 3 under Hypoxic Conditions

(2014) Ho-Youl Lee et al.   MOLECULES AND CELLS

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

(2014) Giuseppe Lo Sasso et al.   PLoS One

Metabolic control of the epigenome in systemic Lupus erythematosus

(2013) Zachary Oaks et al.   AUTOIMMUNITY

Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease

(2013) Y Tang et al.   CELL DEATH AND DIFFERENTIATION

Lysosome-dependent p300/FOXP3 degradation and limits Treg cell functions and enhances targeted therapy against cancers

(2013) Taofeng Du et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Therapeutic Effects of NK-HDAC-1, a Novel Histone Deacetylase Inhibitor, on Collagen-Induced Arthritis Through the Induction of Apoptosis of Fibroblast-Like Synoviocytes

(2013) Minghui Li et al.   INFLAMMATION

Histone Deacetylase 7 Promotes Toll-like Receptor 4-dependent Proinflammatory Gene Expression in Macrophages

(2013) Melanie R. Shakespear et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancer of Zeste Homolog 2 Is a Negative Regulator of Mitochondria-Mediated Innate Immune Responses

(2013) S. Chen et al.   JOURNAL OF IMMUNOLOGY

The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia

(2013) Piotr Przanowski et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Proteomic changes induced by histone demethylase JMJD3 in TNF alpha-treated human monocytic (THP-1) cells

(2013) Amitabh Das et al.   MOLECULAR IMMUNOLOGY

Imbalance between HAT and HDAC Activities in the PBMCs of Patients with Ankylosing Spondylitis or Rheumatoid Arthritis and Influence of HDAC Inhibitors on TNF Alpha Production

(2013) Eric Toussirot et al.   PLoS One

Oncogenic Features of PHF8 Histone Demethylase in Esophageal Squamous Cell Carcinoma

(2013) Xiujing Sun et al.   PLoS One

HDAC7 Is a Repressor of Myeloid Genes Whose Downregulation Is Required for Transdifferentiation of Pre-B Cells into Macrophages

(2013) Bruna Barneda-Zahonero et al.   PLoS Genetics

HDAC inhibitor therapy in autoimmunity and transplantation

(2012) Wayne W Hancock et al.   ANNALS OF THE RHEUMATIC DISEASES

Gene networking and inflammatory pathway analysis in a JMJD3 knockdown human monocytic cell line

(2012) Nando Dulal Das et al.   CELL BIOCHEMISTRY AND FUNCTION

Epigenetic Regulation of Adipogenesis by PHF2 Histone Demethylase

(2012) Y. Okuno et al.   DIABETES

The Histone Methyltransferase Wbp7 Controls Macrophage Function through GPI Glycolipid Anchor Synthesis

(2012) Liv Austenaa et al.   IMMUNITY

KAP1/TRIM28: An inhibitor of IRF5 function in inflammatory macrophages

(2012) H.L. Eames et al.   IMMUNOBIOLOGY

IL-10 Regulates Il12b Expression via Histone Deacetylation: Implications for Intestinal Macrophage Homeostasis

(2012) T. Kobayashi et al.   JOURNAL OF IMMUNOLOGY

Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20

(2012) Joshua D. Stender et al.   MOLECULAR CELL

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

(2012) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation

(2011) S. E. Mullican et al.   GENES & DEVELOPMENT

HDAC inhibitors: modulating leukocyte differentiation, survival, proliferation and inflammation

(2011) Matthew J Sweet et al.   IMMUNOLOGY AND CELL BIOLOGY

GCN5 Regulates the Superoxide-Generating System in Leukocytes Via Controlling gp91-phox Gene Expression

(2011) H. Kikuchi et al.   JOURNAL OF IMMUNOLOGY

PKA-dependent regulation of the histone lysine demethylase complex PHF2–ARID5B

(2011) Atsushi Baba et al.   NATURE CELL BIOLOGY

Histone deacetylases as regulators of inflammation and immunity

(2011) Melanie R. Shakespear et al.   TRENDS IN IMMUNOLOGY

Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection

(2010) T. Roger et al.   BLOOD

Structural insights into a novel histone demethylase PHF8

(2010) Lin Yu et al.   CELL RESEARCH

Recognition of Histone H3K4 Trimethylation by the Plant Homeodomain of PHF2 Modulates Histone Demethylation

(2010) Hong Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Requirement of Histone Acetylase and Deacetylase Activities for IRF5-Mediated Proinflammatory Cytokine Expression

(2010) D. Feng et al.   JOURNAL OF IMMUNOLOGY

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS

(2010) Maria A. Halili et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development

(2010) Hank H. Qi et al.   NATURE

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

Epigenetic regulation of the alternatively activated macrophage phenotype

(2009) M. Ishii et al.   BLOOD

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization

(2009) J. van Loosdregt et al.   BLOOD

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

(2009) Francesca De Santa et al.   EMBO JOURNAL

A phosphorylation-acetylation switch regulates STAT1 signaling

(2009) O. H. Kramer et al.   GENES & DEVELOPMENT

Global H4 acetylation analysis by ChIP-chip in systemic lupus erythematosus monocytes

(2009) Z Zhang et al.   GENES AND IMMUNITY

The NF-κB Factor RelB and Histone H3 Lysine Methyltransferase G9a Directly Interact to Generate Epigenetic Silencing in Endotoxin Tolerance

(2009) Xiaoping Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

(2009) John R Horton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic protein methylation in chromatin biology

(2008) S. S. Ng et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice

(2008) Christopher M. Reilly et al.   JOURNAL OF AUTOIMMUNITY

Role of the Histone H3 Lysine 4 Methyltransferase, SET7/9, in the Regulation of NF-κB-dependent Inflammatory Genes

(2008) Yan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class-specific Regulation of Pro-inflammatory Genes by MyD88 Pathways and IκBζ

(2008) Hisako Kayama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G9a and HP1 Couple Histone and DNA Methylation to TNFα Transcription Silencing during Endotoxin Tolerance

(2008) Mohamed El Gazzar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling

(2008) Wangsen Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protein Arginine Methyltransferase 1 Coactivates NF-κB-Dependent Gene Expression Synergistically with CARM1 and PARP1

(2008) Paul O. Hassa et al.   JOURNAL OF MOLECULAR BIOLOGY

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY