Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms

A Combinatorial MAP Code Dictates Polarized Microtubule Transport

(2020) Brigette Y. Monroy et al.   DEVELOPMENTAL CELL

A Rare KIF1A Missense Mutation Enhances Synaptic Function and Increases Seizure Activity

(2020) Yi Guo et al.   Frontiers in Genetics

Force production of human cytoplasmic dynein is limited by its processivity

(2020) Sibylle Brenner et al.   Science Advances

Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative disorders

(2020) Francesco Nicita et al.   JOURNAL OF MEDICAL GENETICS

The Neurodevelopmental Spectrum of Synaptic Vesicle Cycling Disorders

(2020) Abinayah John et al.   JOURNAL OF NEUROCHEMISTRY

A kinetic dissection of the fast and superprocessive kinesin-3 KIF1A reveals a predominate one-head-bound state during its chemomechanical cycle

(2020) Taylor Mae Zaniewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinesin-3 Responds to Local Microtubule Dynamics to Target Synaptic Cargo Delivery to the Presynapse

(2019) Pedro Guedes-Dias et al.   CURRENT BIOLOGY

Intracellular cargo transport by single-headed kinesin motors

(2019) Kristin I. Schimert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyglutamylation of tubulin’s C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A

(2019) Dominique V Lessard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Motor Dynamics Underlying Cargo Transport by Pairs of Kinesin-1 and Kinesin-3 Motors

(2019) Göker Arpağ et al.   BIOPHYSICAL JOURNAL

Force Generated by Two Kinesin Motors Depends on the Load Direction and Intermolecular Coupling

(2019) Hamid Khataee et al.   PHYSICAL REVIEW LETTERS

Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

(2019) Breane G Budaitis et al.   eLife

Cryo-EM structure of the Ustilago maydis kinesin-5 motor domain bound to microtubules

(2019) Ottilie von Loeffelholz et al.   JOURNAL OF STRUCTURAL BIOLOGY

PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport

(2019) Nida Siddiqui et al.   Nature Communications

Molecular mechanism of cytoplasmic dynein tension sensing

(2019) Lu Rao et al.   Nature Communications

Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors

(2019) Kyoko Chiba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins

(2019) Wonmuk Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Going Too Far Is the Same as Falling Short†: Kinesin-3 Family Members in Hereditary Spastic Paraplegia

(2019) Dominik R. Gabrych et al.   Frontiers in Cellular Neuroscience

Modulation of Kinesin’s Load-Bearing Capacity by Force Geometry and the Microtubule Track

(2019) Serapion Pyrpassopoulos et al.   BIOPHYSICAL JOURNAL

Mobility Characteristics of Children with Spastic Paraplegia Due to a Mutation in the KIF1A Gene

(2019) A.E Van Beusichem et al.   NEUROPEDIATRICS

Autoinhibition of kinesin-1 is essential to the dendrite-specific localization of Golgi outposts

(2018) Michael T. Kelliher et al.   JOURNAL OF CELL BIOLOGY

Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement

(2018) Jinqi Ren et al.   JOURNAL OF MOLECULAR BIOLOGY

Non-invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by ARL-8

(2018) Kumiko Hayashi et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function

(2018) Joseph M. Muretta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Competition between microtubule-associated proteins directs motor transport

(2018) Brigette Y. Monroy et al.   Nature Communications

Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin

(2018) Eva P. Karasmanis et al.   DEVELOPMENTAL CELL

Application of the fluctuation theorem for noninvasive force measurement in living neuronal axons

(2018) Kumiko Hayashi et al.   MOLECULAR BIOLOGY OF THE CELL

Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition

(2018) Jinqi Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load

(2017) Bojan Milic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin rotates unidirectionally and generates torque while walking on microtubules

(2017) Avin Ramaiya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin motility driven by subdomain dynamics

(2017) Wonmuk Hwang et al.   eLife

The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry

(2017) Joseph Atherton et al.   eLife

Targeted high throughput sequencing in hereditary ataxia and spastic paraplegia

(2017) Zafar Iqbal et al.   PLoS One

Allostery Wiring Map for Kinesin Energy Transduction and Its Evolution

(2016) Jessica Richard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping the Processivity Determinants of the Kinesin-3 Motor Domain

(2015) Guido Scarabelli et al.   BIOPHYSICAL JOURNAL

Influence of Fluorescent Tag on the Motility Properties of Kinesin-1 in Single-Molecule Assays

(2015) Stephen R. Norris et al.   BIOPHYSICAL JOURNAL

The Mechanochemical Cycle of Mammalian Kinesin-2 KIF3A/B under Load

(2015) Johan O.L. Andreasson et al.   CURRENT BIOLOGY

Measuring Pushing and Braking Forces Generated by Ensembles of Kinesin-5 Crosslinking Two Microtubules

(2015) Yuta Shimamoto et al.   DEVELOPMENTAL CELL

The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5

(2015) Joseph M. Muretta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transport by Populations of Fast and Slow Kinesins Uncovers Novel Family-Dependent Motor Characteristics Important for In Vivo Function

(2014) Göker Arpağ et al.   BIOPHYSICAL JOURNAL

Integrating protein structural dynamics and evolutionary analysis with Bio3D

(2014) Lars Skjærven et al.   BMC BIOINFORMATICS

Kinesin-2 KIF3AB Exhibits Novel ATPase Characteristics

(2014) Clayton D. Albracht et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A method for multiprotein assembly in cells reveals independent action of kinesins in complex

(2014) Stephen R. Norris et al.   JOURNAL OF CELL BIOLOGY

The family-specific K-loop influences the microtubule on-rate but not the superprocessivity of kinesin-3 motors

(2014) Virupakshi Soppina et al.   MOLECULAR BIOLOGY OF THE CELL

Human CFEOM1 Mutations Attenuate KIF21A Autoinhibition and Cause Oculomotor Axon Stalling

(2014) Long Cheng et al.   NEURON

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family

(2014) Adeline Goulet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimerization of mammalian kinesin-3 motors results in superprocessive motion

(2014) V. Soppina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delineating cooperative responses of processive motors in living cells

(2014) A. K. Efremov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement

(2014) Luyan Cao et al.   Nature Communications

High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation

(2014) Zhiguo Shang et al.   eLife

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

(2014) Joseph Atherton et al.   eLife

The CC1-FHA dimer is essential for KIF1A-mediated axonal transport of synaptic vesicles in C. elegans

(2013) Yang Yue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Single-Molecule Motility: Statistical Analysis and the Effects of Track Length on Quantification of Processive Motion

(2013) Andrew R. Thompson et al.   BIOPHYSICAL JOURNAL

Modular Aspects of Kinesin Force Generation Machinery

(2013) William R. Hesse et al.   BIOPHYSICAL JOURNAL

Force-Dependent Detachment of Kinesin-2 Biases Track Switching at Cytoskeletal Filament Intersections

(2012) Harry W. Schroeder et al.   BIOPHYSICAL JOURNAL

The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5

(2012) Adeline Goulet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CC1-FHA Tandem as a Central Hub for Controlling the Dimerization and Activation of Kinesin-3 KIF1A

(2012) Lin Huo et al.   STRUCTURE

KIF1A is the primary anterograde motor protein required for the axonal transport of dense-core vesicles in cultured hippocampal neurons

(2011) K.Y. Lo et al.   NEUROSCIENCE LETTERS

Probing Intracellular Motor Protein Activity Using an Inducible Cargo Trafficking Assay

(2010) Lukas C. Kapitein et al.   BIOPHYSICAL JOURNAL

Kinesin-73 Is a Processive Motor That Localizes to Rab5-containing Organelles

(2010) Thomas M. Huckaba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Force and Premature Binding of ADP Can Regulate the Processivity of Individual Eg5 Dimers

(2009) Megan T. Valentine et al.   BIOPHYSICAL JOURNAL

Direct observation of the binding state of the kinesin head to the microtubule

(2009) Nicholas R. Guydosh et al.   NATURE

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mammalian Kinesin-3 Motors Are Dimeric In Vivo and Move by Processive Motility upon Release of Autoinhibition

(2009) Jennetta W Hammond et al.   PLOS BIOLOGY

Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin

(2008) Ryo Nitta et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Kinesin's cover-neck bundle folds forward to generate force

(2008) A. S. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force Generation in Kinesin Hinges on Cover-Neck Bundle Formation

(2008) Wonmuk Hwang et al.   STRUCTURE

Identification of an Axonal Kinesin-3 Motor for Fast Anterograde Vesicle Transport that Facilitates Retrograde Transport of Neuropeptides

(2007) Rosemarie V. Barkus et al.   MOLECULAR BIOLOGY OF THE CELL