Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

Intracellular cargo transport by single-headed kinesin motors

(2019) Kristin I. Schimert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Motor Reattachment Kinetics Play a Dominant Role in Multimotor-Driven Cargo Transport

(2018) Qingzhou Feng et al.   BIOPHYSICAL JOURNAL

Processive Kinesin-14 HSET Exhibits Directional Flexibility Depending on Motor Traffic

(2018) Dana N. Reinemann et al.   CURRENT BIOLOGY

Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement

(2018) Jinqi Ren et al.   JOURNAL OF MOLECULAR BIOLOGY

A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function

(2018) Joseph M. Muretta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin motility driven by subdomain dynamics

(2017) Wonmuk Hwang et al.   eLife

The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry

(2017) Joseph Atherton et al.   eLife

Structural basis of cooperativity in kinesin revealed by 3D reconstruction of a two-head-bound state on microtubules

(2017) Daifei Liu et al.   eLife

Direct observation of intermediate states during the stepping motion of kinesin-1

(2016) Hiroshi Isojima et al.   Nature Chemical Biology

Engineered kinesin motor proteins amenable to small-molecule inhibition

(2016) Martin F. Engelke et al.   Nature Communications

The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5

(2015) Joseph M. Muretta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin’s Front Head Is Gated by the Backward Orientation of Its Neck Linker

(2015) Merve Yusra Dogan et al.   Cell Reports

Examining kinesin processivity within a general gating framework

(2015) Johan OL Andreasson et al.   eLife

Transport by Populations of Fast and Slow Kinesins Uncovers Novel Family-Dependent Motor Characteristics Important for In Vivo Function

(2014) Göker Arpağ et al.   BIOPHYSICAL JOURNAL

Integrating protein structural dynamics and evolutionary analysis with Bio3D

(2014) Lars Skjærven et al.   BMC BIOINFORMATICS

Mechanical Role of Actin Dynamics in the Rheology of the Golgi Complex and in Golgi-Associated Trafficking Events

(2014) David Guet et al.   CURRENT BIOLOGY

A method for multiprotein assembly in cells reveals independent action of kinesins in complex

(2014) Stephen R. Norris et al.   JOURNAL OF CELL BIOLOGY

KIF14 Binds Tightly to Microtubules and Adopts a Rigor-Like Conformation

(2014) Kritica Arora et al.   JOURNAL OF MOLECULAR BIOLOGY

The family-specific K-loop influences the microtubule on-rate but not the superprocessivity of kinesin-3 motors

(2014) Virupakshi Soppina et al.   MOLECULAR BIOLOGY OF THE CELL

γ-Tubulin controls neuronal microtubule polarity independently of Golgi outposts

(2014) Michelle M. Nguyen et al.   MOLECULAR BIOLOGY OF THE CELL

Motor coupling through lipid membranes enhances transport velocities for ensembles of myosin Va

(2014) S. R. Nelson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimerization of mammalian kinesin-3 motors results in superprocessive motion

(2014) V. Soppina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delineating cooperative responses of processive motors in living cells

(2014) A. K. Efremov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement

(2014) Luyan Cao et al.   Nature Communications

High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation

(2014) Zhiguo Shang et al.   eLife

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

(2014) Joseph Atherton et al.   eLife

Kinesin-8 Is a Low-Force Motor Protein with a Weakly Bound Slip State

(2013) Anita Jannasch et al.   BIOPHYSICAL JOURNAL

Modular Aspects of Kinesin Force Generation Machinery

(2013) William R. Hesse et al.   BIOPHYSICAL JOURNAL

Structure of a kinesin–tubulin complex and implications for kinesin motility

(2013) Benoît Gigant et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recycling of Kinesin-1 Motors by Diffusion after Transport

(2013) T. Lynne Blasius et al.   PLoS One

Mapping the Structural and Dynamical Features of Kinesin Motor Domains

(2013) Guido Scarabelli et al.   PLoS Computational Biology

Kif18A Uses a Microtubule Binding Site in the Tail for Plus-End Localization and Spindle Length Regulation

(2011) Lesley N. Weaver et al.   CURRENT BIOLOGY

A universal pathway for kinesin stepping

(2011) Bason E Clancy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interhead tension determines processivity across diverse N-terminal kinesins

(2011) S. Shastry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing Intracellular Motor Protein Activity Using an Inducible Cargo Trafficking Assay

(2010) Lukas C. Kapitein et al.   BIOPHYSICAL JOURNAL

Motor Proteins: Kinesin Drives with an Underhead Cam

(2010) Matthew J. Lang et al.   CURRENT BIOLOGY

Neck Linker Length Determines the Degree of Processivity in Kinesin-1 and Kinesin-2 Motors

(2010) Shankar Shastry et al.   CURRENT BIOLOGY

Kinesin-73 Is a Processive Motor That Localizes to Rab5-containing Organelles

(2010) Thomas M. Huckaba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An atomic-level mechanism for activation of the kinesin molecular motors

(2010) C. V. Sindelar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of membrane nanotube formation by molecular motors

(2009) Cécile Leduc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Insights into the Mechanical Properties of the Kinesin Neck Linker Domain from Sequence Analysis and Molecular Dynamics Simulations

(2009) Venkatesh Hariharan et al.   Cellular and Molecular Bioengineering

The Processivity of Kinesin-2 Motors Suggests Diminished Front-Head Gating

(2009) Gayatri Muthukrishnan et al.   CURRENT BIOLOGY

ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-water Mechanism

(2009) Courtney L. Parke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Traffic control: regulation of kinesin motors

(2009) Kristen J. Verhey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular motors and the Golgi complex: Staying put and moving through

(2009) Kim Brownhill et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Intramolecular Strain Coordinates Kinesin Stepping Behavior along Microtubules

(2008) Ahmet Yildiz et al.   CELL

Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin

(2008) Ryo Nitta et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Kinesin's cover-neck bundle folds forward to generate force

(2008) A. S. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Very fast prediction and rationalization of pKa values for protein-ligand complexes

(2008) Delphine C. Bas et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Force Generation in Kinesin Hinges on Cover-Neck Bundle Formation

(2008) Wonmuk Hwang et al.   STRUCTURE