How Kinesin-1 Utilize the Energy of Nucleotide: The Conformational Changes and Mechanochemical Coupling in the Unidirectional Motion of Kinesin-1

Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments

(2020) Verena Henrichs et al.   Nature Communications

Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

(2019) Breane G Budaitis et al.   eLife

Shaft Function of Kinesin-1’s α4 Helix in the Processive Movement

(2019) Yi-Long Ma et al.   Cellular and Molecular Bioengineering

Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins

(2019) Wonmuk Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

All‐atom molecular dynamics simulations reveal how kinesin transits from one‐head‐bound to two‐heads‐bound state

(2019) Xiao‐Xuan Shi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Run length distribution of dimerized kinesin-3 molecular motors: comparison with dimeric kinesin-1

(2019) Si-Kao Guo et al.   Scientific Reports

Bidirectional motility of kinesin-5 motor proteins: structural determinants, cumulative functions and physiological roles

(2018) Sudhir Kumar Singh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protection-against-water-attack determined difference between strengths of backbone hydrogen bonds in kinesin’s neck zipper region

(2018) Jing-Yu Qin et al.   Chinese Physics B

Mechanochemical Model of the Power Stroke of the Single-Headed Motor Protein KIF1A

(2018) Fei Liu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Insights into Kinesin-1 Activation from the Crystal Structure of KLC2 Bound to JIP3

(2018) Joseph J.B. Cockburn et al.   STRUCTURE

Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin

(2017) Weiyi Wang et al.   Nature Communications

Kinesin motility driven by subdomain dynamics

(2017) Wonmuk Hwang et al.   eLife

The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry

(2017) Joseph Atherton et al.   eLife

Structural basis of cooperativity in kinesin revealed by 3D reconstruction of a two-head-bound state on microtubules

(2017) Daifei Liu et al.   eLife

The structural switch of nucleotide-free kinesin

(2017) Luyan Cao et al.   Scientific Reports

The Kinesin-1 Chemomechanical Cycle: Stepping Toward a Consensus

(2016) William O. Hancock   BIOPHYSICAL JOURNAL

Structural Basis of Backwards Motion in Kinesin-1-Kinesin-14 Chimera: Implication for Kinesin-14 Motility

(2016) Masahiko Yamagishi et al.   STRUCTURE

Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A

(2016) Doudou Wang et al.   eLife

X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding

(2015) M. Morikawa et al.   EMBO JOURNAL

Kinesin superfamily proteins (KIFs): Various functions and their relevance for important phenomena in life and diseases

(2015) Nobutaka Hirokawa et al.   EXPERIMENTAL CELL RESEARCH

The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5

(2015) Joseph M. Muretta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle

(2015) Keith J. Mickolajczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin, 30 years later: Recent insights from structural studies

(2015) Weiyi Wang et al.   PROTEIN SCIENCE

Kinesin’s Front Head Is Gated by the Backward Orientation of Its Neck Linker

(2015) Merve Yusra Dogan et al.   Cell Reports

Examining kinesin processivity within a general gating framework

(2015) Johan OL Andreasson et al.   eLife

Mechanical amplification mechanism of kinesin’s β-domain

(2014) Yi-Zhao Geng et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Simulation Study of Interactions Between Kinesin’s Neck Linker and Motor Domain

(2014) Yi-Zhao Geng et al.   Cellular and Molecular Bioengineering

Initial conformation of kinesin's neck linker

(2014) Yi-Zhao Geng et al.   Chinese Physics B

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

(2014) Minhajuddin Sirajuddin et al.   NATURE CELL BIOLOGY

Prime movers: the mechanochemistry of mitotic kinesins

(2014) Robert A. Cross et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Allosteric control of kinesin's motor domain by tubulin: a molecular dynamics study

(2014) Aliaksei Krukau et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Kinesin processivity is gated by phosphate release

(2014) Bojan Milic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement

(2014) Luyan Cao et al.   Nature Communications

High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation

(2014) Zhiguo Shang et al.   eLife

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

(2014) Joseph Atherton et al.   eLife

Microtubule-Depolymerizing Kinesins

(2013) Claire E. Walczak et al.   Annual Review of Cell and Developmental Biology

Kinesin-5 Seems to Step to its Own Unique Tune, but Really it’s a Cover

(2013) Sarah E. Rice   BIOPHYSICAL JOURNAL

Modular Aspects of Kinesin Force Generation Machinery

(2013) William R. Hesse et al.   BIOPHYSICAL JOURNAL

Structural Basis for the ATP-Induced Isomerization of Kinesin

(2013) Qing Chang et al.   JOURNAL OF MOLECULAR BIOLOGY

Adenosine Triphosphate Hydrolysis Mechanism in Kinesin Studied by Combined Quantum-Mechanical/Molecular-Mechanical Metadynamics Simulations

(2013) Matthew J. McGrath et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a kinesin–tubulin complex and implications for kinesin motility

(2013) Benoît Gigant et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mapping the Structural and Dynamical Features of Kinesin Motor Domains

(2013) Guido Scarabelli et al.   PLoS Computational Biology

The crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal development

(2013) Marta Klejnot et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mechanism of Processive Movement of Monomeric and Dimeric Kinesin Molecules

(2012) Ping Xie   International Journal of Biological Sciences

The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5

(2012) Adeline Goulet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissecting the Kinematics of the Kinesin Step

(2012) Zhechun Zhang et al.   STRUCTURE

The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization

(2011) Claire T Friel et al.   EMBO JOURNAL

A universal pathway for kinesin stepping

(2011) Bason E Clancy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interhead tension determines processivity across diverse N-terminal kinesins

(2011) S. Shastry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition

(2011) H. Y. K. Kaan et al.   SCIENCE

An atomic-level mechanism for activation of the kinesin molecular motors

(2010) C. V. Sindelar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Half-Site Inhibition of Dimeric Kinesin Head Domains by Monomeric Tail Domains†

(2009) David D. Hackney et al.   BIOCHEMISTRY

ATPase Cycle of the Nonmotile Kinesin NOD Allows Microtubule End Tracking and Drives Chromosome Movement

(2009) Jared C. Cochran et al.   CELL

Insights into the Mechanical Properties of the Kinesin Neck Linker Domain from Sequence Analysis and Molecular Dynamics Simulations

(2009) Venkatesh Hariharan et al.   Cellular and Molecular Bioengineering

ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-water Mechanism

(2009) Courtney L. Parke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tubulin tyrosination navigates the kinesin-1 motor domain to axons

(2009) Yoshiyuki Konishi et al.   NATURE NEUROSCIENCE

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Why kinesin is so processive

(2009) E. Toprak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mobile kinesin-head intermediate during the ATP-waiting state

(2009) A. B. Asenjo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin Tail Domains and Mg2+Directly Inhibit Release of ADP from Head Domains in the Absence of Microtubules†

(2008) David D. Hackney et al.   BIOCHEMISTRY

Intramolecular Strain Coordinates Kinesin Stepping Behavior along Microtubules

(2008) Ahmet Yildiz et al.   CELL

Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells

(2008) S. Dunn et al.   JOURNAL OF CELL SCIENCE

High-Resolution Crystal Structure and In Vivo Function of a Kinesin-2 Homologue in Giardia intestinalis

(2008) J. C. Hoeng et al.   MOLECULAR BIOLOGY OF THE CELL

Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin

(2008) Ryo Nitta et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Kinesin's cover-neck bundle folds forward to generate force

(2008) A. S. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force Generation in Kinesin Hinges on Cover-Neck Bundle Formation

(2008) Wonmuk Hwang et al.   STRUCTURE

The role of microtubules in processive kinesin movement

(2008) Masahide Kikkawa   TRENDS IN CELL BIOLOGY