Clonal hematopoiesis: Mutation-specific adaptation to environmental change

TET2-Driven Clonal Hematopoiesis and Response to Canakinumab

(2022) Eric C. Svensson et al.   JAMA Cardiology

Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming

(2021) Yao Wang et al.   Nature Communications

Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis

(2021) Alexander Heyde et al.   CELL

Crucial role of hematopoietic JAK2V617F in the development of aortic aneurysms

(2021) Tetsuro Yokokawa et al.   HAEMATOLOGICA

Clonal hematopoiesis before, during, and after human spaceflight

(2021) Nuria Mencia-Trinchant et al.   Cell Reports

Healthy Lifestyle and Clonal Hematopoiesis of Indeterminate Potential: Results From the Women's Health Initiative

(2021) Bernhard Haring et al.   Journal of the American Heart Association

Graft‐versus‐host disease after liver transplantation is associated with bone marrow failure, hemophagocytosis, and DNMT3A mutations

(2021) Laura F. Newell et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling

(2021) Daniel Hormaechea-Agulla et al.   Cell Stem Cell

Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors

(2021) Kelly C. Higa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway

(2021) Takeshi Fujino et al.   Nature Communications

Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation

(2021) L. Alexander Liggett et al.   Blood Advances

Prevalence, predictors, and outcomes of clonal hematopoiesis in individuals aged ≥80 years

(2021) Isabelle A. van Zeventer et al.   Blood Advances

Impact of splicing mutations in acute myeloid leukemia treated with hypomethylating agents combined with venetoclax

(2021) Curtis A. Lachowiez et al.   Blood Advances

Clonal hematopoiesis associated with epigenetic aging and clinical outcomes

(2021) Daniel Nachun et al.   AGING CELL

Clonal hematopoiesis in sickle cell disease

(2021) Thomas Pincez et al.   BLOOD

The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice

(2021) Yoshimitsu Yura et al.   CIRCULATION RESEARCH

Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection

(2021) Francisco Caiado et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Association of Clonal Hematopoiesis With Incident Heart Failure

(2021) Bing Yu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease

(2021) Ahmed A. Z. Dawoud et al.   LEUKEMIA

Epigenetic strategies to boost CAR T cell therapy

(2021) Behnia Akbari et al.   MOLECULAR THERAPY

HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults

(2021) Nila J. Dharan et al.   NATURE MEDICINE

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

(2021) Seyedeh M. Zekavat et al.   NATURE MEDICINE

Clonal Hematopoiesis after Autologous Stem Cell Transplantation Does Not Confer Adverse Prognosis in Patients with AML

(2021) Alexander D. Heini et al.   Cancers

TP53-mediated therapy-related clonal hematopoiesis contributes to doxorubicin-induced cardiomyopathy by augmenting a neutrophil-mediated cytotoxic response

(2021) Soichi Sano et al.   JCI Insight

DNMT3A Mutation-Induced CDK1 Overexpression Promotes Leukemogenesis by Modulating the Interaction between EZH2 and DNMT3A

(2021) Ying Yang et al.   Biomolecules

Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy

(2021) Peter G. Miller et al.   Blood Advances

Association of clonal hematopoiesis with chronic obstructive pulmonary disease

(2021) Peter G. Miller et al.   BLOOD

Fatty Bone Marrow Positively Selects Pre-Leukemic HSPCs with a DNMT3A-mutation

(2021) Naama Zioni et al.   BLOOD

The Association between Clonal Hematopoiesis and Gout

(2021) Mridul Agrawal et al.   BLOOD

Tet2 deficiency in immune cells exacerbates tumor progression by increasing angiogenesis in a lung cancer model

(2021) Yen T. M. Nguyen et al.   CANCER SCIENCE

Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis

(2021) Peter Geon Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis

(2021) S. Avagyan et al.   SCIENCE

Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity

(2021) Brooke Prinzing et al.   Science Translational Medicine

Clonal Hematopoiesis Is Associated With Higher Risk of Stroke

(2021) Romit Bhattacharya et al.   STROKE

Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils

(2021) Yusuke Kimishima et al.   Nature Communications

Clonal hematopoiesis is associated with risk of severe Covid-19

(2021) Kelly L. Bolton et al.   Nature Communications

Enriched clonal hematopoiesis in seniors with dietary vitamin C inadequacy

(2021) Jiaqi Chen et al.   Clinical Nutrition ESPEN

Co-occurrence of DNMT3A, NPM1, FLT3 mutations identifies a subset of acute myeloid leukemia with adverse prognosis

(2020) Matheus F Bezerra et al.   BLOOD

Cancer as a disease of old age: changing mutational and microenvironmental landscapes

(2020) Ezio Laconi et al.   BRITISH JOURNAL OF CANCER

ASXL1 mutation in clonal hematopoiesis

(2020) Takeshi Fujino et al.   EXPERIMENTAL HEMATOLOGY

Interplay between Clonal Hematopoiesis of Indeterminate Potential and Metabolism

(2020) Man K.S. Lee et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Clonal hematopoiesis evolves from pretreatment clones and stabilizes after end of chemotherapy in patients with MCL

(2020) Christian Winther Eskelund et al.   BLOOD

Prevalence and dynamics of clonal hematopoiesis caused by leukemia-associated mutations in elderly individuals without hematologic disorders

(2020) Danica Midic et al.   LEUKEMIA

DNA methylation disruption reshapes the hematopoietic differentiation landscape

(2020) Franco Izzo et al.   NATURE GENETICS

The evolutionary dynamics and fitness landscape of clonal hematopoiesis

(2020) Caroline J. Watson et al.   SCIENCE

EM-mosaic detects mosaic point mutations that contribute to congenital heart disease

(2020) Alexander Hsieh et al.   Genome Medicine

Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness

(2020) Elizabeth L. Ostrander et al.   Stem Cell Reports

The Clinical Challenge of Clonal Hematopoiesis, a Newly Recognized Cardiovascular Risk Factor

(2020) Robert Sidlow et al.   JAMA Cardiology

Mutation profile and prognostic relevance in elderly patients with de novo acute myeloid leukemia treated with decitabine‐based chemotherapy

(2020) Jing Ni et al.   International Journal of Laboratory Hematology

Clonal myelopoiesis in the UK Biobank cohort: ASXL1 mutations are strongly associated with smoking

(2020) Ahmed A. Z. Dawoud et al.   LEUKEMIA

Autoimmunity, Clonal Hematopoiesis, and Myeloid Neoplasms

(2020) Delamo I. Bekele et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Survival differences and associated molecular signatures of DNMT3A-mutant acute myeloid leukemia patients

(2020) Chris Lauber et al.   Scientific Reports

Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions

(2020) Leanna Morinishi et al.   Cell Systems

Multiple Somatic Mutations for Clonal Hematopoiesis Are Associated with Increased Mortality in Patients with Chronic Heart Failure

(2020) Sebastian Cremer et al.   Circulation-Genomic and Precision Medicine

The clinical implications of clonal hematopoiesis in hematopoietic cell transplantation

(2020) Mariam T. Nawas et al.   BLOOD REVIEWS

Alterations to DNMT3A in Hematologic Malignancies

(2020) Kartika Venugopal et al.   CANCER RESEARCH

Dnmt3a-null hematopoietic stem and progenitor cells expand after busulfan treatment

(2020) Jichun Chen et al.   EXPERIMENTAL HEMATOLOGY

Cancer therapy shapes the fitness landscape of clonal hematopoiesis

(2020) Kelly L. Bolton et al.   NATURE GENETICS

Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure

(2020) Wesley Tyler Abplanalp et al.   CIRCULATION RESEARCH

Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine–induced lncRNA Morrbid

(2020) Zhigang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Normal Somatic Mutations in Cancer Transformation

(2020) Neshika Wijewardhane et al.   CANCER CELL

Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women

(2020) Michael C. Honigberg et al.   CIRCULATION

Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice

(2019) Wei Wang et al.   CIRCULATION RESEARCH

Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor

(2019) Allison Gartung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The emerging role of epigenetics in human autoimmune disorders

(2019) Roberta Mazzone et al.   Clinical Epigenetics

Hematologic Complications of Immune Checkpoint Inhibitors

(2019) Elizabeth J. Davis et al.   ONCOLOGIST

Haematopoietic stem cell activity and interactions with the niche

(2019) Sandra Pinho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis

(2019) Matthew A. Loberg et al.   LEUKEMIA

Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners

(2019) Jonathan E. Sandoval et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Causes and Mechanisms of Hematopoietic Stem Cell Aging

(2019) Jungwoon Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myeloid disorders after autoimmune disease

(2019) Prajwal C. Boddu et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells

(2019) Arne Søraas et al.   AGING CELL

The prognostic impact of tet oncogene family member 2 mutations in patients with acute myeloid leukemia: a systematic-review and meta-analysis

(2019) Ruiqi Wang et al.   BMC CANCER

p53 involvement in clonal hematopoiesis of indeterminate potential

(2019) Sisi Chen et al.   CURRENT OPINION IN HEMATOLOGY

Clonal haematopoiesis and risk of acute myeloid leukemia.

(2019) Andrew L. Young et al.   HAEMATOLOGICA

Functional Dominance of CHIP-Mutated Hematopoietic Stem Cells in Patients Undergoing Autologous Transplantation

(2019) Christina A. Ortmann et al.   Cell Reports

A generalized theory of age-dependent carcinogenesis

(2019) Andrii Rozhok et al.   eLife

TET2 Function in Hematopoietic Malignancies, Immune Regulation, and DNA Repair

(2019) Yimei Feng et al.   Frontiers in Oncology

TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration

(2019) Masayuki Yamashita et al.   Cell Stem Cell

Clonal Hematopoiesis

(2019) Peter Libby et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Somatic mosaic truncating mutations of PPM1D in blood can result from expansion of a mutant clone under selective pressure of chemotherapy

(2019) Borahm Kim et al.   PLoS One

Paradoxical association of TET loss of function with genome-wide DNA hypomethylation

(2019) Isaac F. López-Moyado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-related clonal haemopoiesis is associated with increased epigenetic age

(2019) Neil A. Robertson et al.   CURRENT BIOLOGY

Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation

(2019) Silvia Mas-Peiro et al.   EUROPEAN HEART JOURNAL

Genetic IL-6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis

(2019) Alexander G. Bick et al.   CIRCULATION

Conditioning Regimens for Hematopoietic Cell Transplantation in Primary Immunodeficiency

(2019) S. H. Lum et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Clonal hematopoiesis in human aging and disease

(2019) Siddhartha Jaiswal et al.   SCIENCE

Antibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies

(2019) Hongxiang Zeng et al.   CANCER LETTERS

Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients

(2019) Christine R.C. Zhang et al.   EXPERIMENTAL HEMATOLOGY

Environmental influences on clonal hematopoiesis

(2019) Katherine Y. King et al.   EXPERIMENTAL HEMATOLOGY

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

(2019) Sisi Chen et al.   Nature Communications

PPM1D truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

(2018) Josephine D. Kahn et al.   BLOOD

CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular DiseaseNovelty and Significance

(2018) Soichi Sano et al.   CIRCULATION RESEARCH

IDH1/2Mutations Sensitize Acute Myeloid Leukemia to PARP Inhibition and This Is Reversed by IDH1/2-Mutant Inhibitors

(2018) Remco J. Molenaar et al.   CLINICAL CANCER RESEARCH

An inflammatory environment containing TNFα favors Tet2 -mutant clonal hematopoiesis

(2018) Samuel O. Abegunde et al.   EXPERIMENTAL HEMATOLOGY

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

(2018) Soichi Sano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clonal hematopoiesis in patients with multiple myeloma undergoing autologous stem cell transplantation

(2018) Sneha Chitre et al.   LEUKEMIA

Constitutional mutations of the CHEK2 gene are a risk factor for MDS, but not for de novo AML

(2018) Hanna Janiszewska et al.   LEUKEMIA RESEARCH

Clinical Implications of Clonal Hematopoiesis

(2018) David P. Steensma   MAYO CLINIC PROCEEDINGS

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

(2018) Marlies Meisel et al.   NATURE

Somatic mutations precede acute myeloid leukemia years before diagnosis

(2018) Pinkal Desai et al.   NATURE MEDICINE

Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells

(2018) Margherita Norelli et al.   NATURE MEDICINE

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

(2018) Ofir Wolach et al.   Science Translational Medicine

Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential

(2018) Terrence N. Wong et al.   Nature Communications

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo

(2018) Mira Jeong et al.   Cell Reports

Optimal conditioning regimen for haplo-identical stem cell transplantation in adult patients with acquired severe aplastic anemia: Prospective de-escalation study of TBI and ATG dose

(2018) Sung-Eun Lee et al.   AMERICAN JOURNAL OF HEMATOLOGY

Clonal Hematopoiesis and Its Impact on Cardiovascular Disease

(2018) Soichi Sano et al.   CIRCULATION JOURNAL

Metabolism as master of hematopoietic stem cell fate

(2018) Kyoko Ito et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Radioactive iodine-related clonal hematopoiesis in thyroid cancer is common and associated with decreased survival

(2018) Laura Boucai et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Prediction of acute myeloid leukaemia risk in healthy individuals

(2018) Sagi Abelson et al.   NATURE

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

(2018) Joseph A. Fraietta et al.   NATURE

Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer

(2018) Di Wu et al.   NATURE

Clonal hematopoiesis in patients with rheumatoid arthritis

(2018) Paula Savola et al.   Blood Cancer Journal

Clinical impact of clonal hematopoiesis in acute myeloid leukemia patients receiving allogeneic transplantation

(2018) Juliane Grimm et al.   BONE MARROW TRANSPLANTATION

Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia

(2018) Andrew M. Brunner et al.   CANCER

The Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells

(2018) Megan E. McNerney et al.   Cell Stem Cell

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

(2018) Joanne I. Hsu et al.   Cell Stem Cell

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

(2018) Zhigang Cai et al.   Cell Stem Cell

Role of Donor Clonal Hematopoiesis in Allogeneic Hematopoietic Stem-Cell Transplantation

(2018) Mareike Frick et al.   JOURNAL OF CLINICAL ONCOLOGY

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure

(2018) Lena Dorsheimer et al.   JAMA Cardiology

Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma

(2017) Christopher J. Gibson et al.   JOURNAL OF CLINICAL ONCOLOGY

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Clonal haemopoiesis and therapy-related myeloid malignancies in elderly patients: a proof-of-concept, case-control study

(2017) Nancy K Gillis et al.   LANCET ONCOLOGY

Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation

(2017) R. Coleman Lindsley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

(2017) José J. Fuster et al.   SCIENCE

Accumulation of DNA damage in the aged hematopoietic stem cell compartment

(2017) Isabel Beerman   SEMINARS IN HEMATOLOGY

Clonal hematopoiesis

(2017) Max Jan et al.   SEMINARS IN HEMATOLOGY

TET2 in Normal and Malignant Hematopoiesis

(2017) Robert L. Bowman et al.   Cold Spring Harbor Perspectives in Medicine

Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis

(2017) Sabah F. Chaudry et al.   Biomed Research International

Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota

(2016) Kamilla S. Josefsdottir et al.   BLOOD

The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis

(2016) K. B. Schoedel et al.   BLOOD

Clonal hematopoiesis in acquired aplastic anemia

(2016) S. Ogawa   BLOOD

DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias

(2016) Liubin Yang et al.   CANCER CELL

Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts

(2016) A Mupo et al.   LEUKEMIA

DNMT3A R882 Mutations Predict a Poor Prognosis in AML

(2016) Xiao-Qing Yuan et al.   MEDICINE

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

(2016) Olga A Guryanova et al.   NATURE MEDICINE

De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+T-cell fate decisions following activation

(2016) Brian H. Ladle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia

(2016) S. E. Meyer et al.   Cancer Discovery

Evaluation of DNMT3A genetic polymorphisms as outcome predictors in AML patients

(2016) Xiao-Qing Yuan et al.   Oncotarget

Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation

(2016) Katie A. Matatall et al.   Cell Reports

Trisomy 21 consistently activates the interferon response

(2016) Kelly D Sullivan et al.   eLife

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment

(2016) Larisa V. Kovtonyuk et al.   Frontiers in Immunology

Somatic Mosaic Mutations inPPM1DandTP53in the Blood of Women With Ovarian Carcinoma

(2016) Elizabeth M. Swisher et al.   JAMA Oncology

Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML

(2015) T. N. Wong et al.   BLOOD

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients

(2015) A Zajkowicz et al.   BRITISH JOURNAL OF CANCER

Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

(2015) Simona Colla et al.   CANCER CELL

Loss ofTET2in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

(2015) Kasper D. Rasmussen et al.   GENES & DEVELOPMENT

ASXL1 mutations in younger adult patients with acute myeloid leukemia: a study by the German-Austrian Acute Myeloid Leukemia Study Group

(2015) P. Paschka et al.   HAEMATOLOGICA

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia

(2015) Tetsuichi Yoshizato et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins

(2015) Marianne S. Poruchynsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis

(2015) Thomas McKerrell et al.   Cell Reports

ASXL1 mutations in younger adult patients with acute myeloid leukemia: a study by the German-Austrian Acute Myeloid Leukemia Study Group

(2015) P. Paschka et al.   HAEMATOLOGICA

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation

(2014) H. Celik et al.   BLOOD

Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms

(2014) P. Lundberg et al.   BLOOD

The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers

(2014) David A. Russler-Germain et al.   CANCER CELL

TET2as an epigenetic master regulator for normal and malignant hematopoiesis

(2014) Hideaki Nakajima et al.   CANCER SCIENCE

Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal

(2014) Deqiang Sun et al.   Cell Stem Cell

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies

(2014) A P Im et al.   LEUKEMIA

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia

(2014) Terrence N. Wong et al.   NATURE

Age-related mutations associated with clonal hematopoietic expansion and malignancies

(2014) Mingchao Xie et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG)

(2013) V. I. Gaidzik et al.   BLOOD

Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia

(2013) J. Kronke et al.   BLOOD

Clinical and biological implications of driver mutations in myelodysplastic syndromes

(2013) E. Papaemmanuil et al.   BLOOD

Mutations and prognosis in primary myelofibrosis

(2013) A M Vannucchi et al.   LEUKEMIA

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

(2013) T Haferlach et al.   LEUKEMIA

Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

(2013) J. Nangalia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

(2012) A. F. T. Ribeiro et al.   BLOOD

Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases

(2012) Véronique Gelsi-Boyer et al.   Journal of Hematology & Oncology

Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association

(2012) A Renneville et al.   LEUKEMIA

TET2 is essential for survival and hematopoietic stem cell homeostasis

(2012) K Shide et al.   LEUKEMIA

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

(2012) Lambert Busque et al.   NATURE GENETICS

Changes of the cytokine profile in inflammatory bowel diseases

(2012) Györgyi Műzes   WORLD JOURNAL OF GASTROENTEROLOGY

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

(2011) Z. Li et al.   BLOOD

TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics

(2011) W.-C. Chou et al.   BLOOD

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

Acute myeloid leukemia developing in patients with autoimmune diseases

(2011) S. M. Ramadan et al.   HAEMATOLOGICA

Chronic Immune Stimulation Might Act As a Trigger for the Development of Acute Myeloid Leukemia or Myelodysplastic Syndromes

(2011) Sigurdur Y. Kristinsson et al.   JOURNAL OF CLINICAL ONCOLOGY

DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia

(2011) K H Metzeler et al.   LEUKEMIA

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Dnmt3a is essential for hematopoietic stem cell differentiation

(2011) Grant A Challen et al.   NATURE GENETICS

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

(2011) Xiao-Jing Yan et al.   NATURE GENETICS

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition

(2010) Tanya Bondar et al.   Cell Stem Cell

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

(2010) Mary Mohrin et al.   Cell Stem Cell

IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication

(2010) Peter Paschka et al.   JOURNAL OF CLINICAL ONCOLOGY

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Irradiation Selects for p53-Deficient Hematopoietic Progenitors

(2010) Andriy Marusyk et al.   PLOS BIOLOGY

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

(2009) O. Abdel-Wahab et al.   BLOOD

p53 Regulates Hematopoietic Stem Cell Quiescence

(2009) Yan Liu et al.   Cell Stem Cell

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Mutation inTET2in Myeloid Cancers

(2009) François Delhommeau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice

(2008) Jichun Chen et al.   EXPERIMENTAL HEMATOLOGY