Clonal hematopoiesis associated with epigenetic aging and clinical outcomes

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

(2020) Alexander G. Bick et al.   NATURE

Cancer therapy shapes the fitness landscape of clonal hematopoiesis

(2020) Kelly L. Bolton et al.   NATURE GENETICS

DNA methylation GrimAge strongly predicts lifespan and healthspan

(2019) Ake T. Lu et al.   Aging-US

DNA methylation-based estimator of telomere length

(2019) Ake T. Lu et al.   Aging-US

Age-related clonal haemopoiesis is associated with increased epigenetic age

(2019) Neil A. Robertson et al.   CURRENT BIOLOGY

Genetic IL-6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis

(2019) Alexander G. Bick et al.   CIRCULATION

Clonal hematopoiesis in human aging and disease

(2019) Siddhartha Jaiswal et al.   SCIENCE

An epigenetic biomarker of aging for lifespan and healthspan

(2018) Morgan E. Levine et al.   Aging-US

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

(2018) Steve Horvath et al.   NATURE REVIEWS GENETICS

Traumatic stress and accelerated DNA methylation age: A meta-analysis

(2018) Erika J. Wolf et al.   PSYCHONEUROENDOCRINOLOGY

GWAS of epigenetic aging rates in blood reveals a critical role for TERT

(2018) Ake T. Lu et al.   Nature Communications

Aging and the rise of somatic cancer-associated mutations in normal tissues

(2018) Rosa Ana Risques et al.   PLoS Genetics

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

(2018) Steve Horvath et al.   Aging-US

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

(2017) José J. Fuster et al.   SCIENCE

DNA methylation-based measures of biological age: meta-analysis predicting time to death

(2016) Brian H. Chen et al.   Aging-US

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing

(2016) Margaret L. Hoang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort

(2016) Laura Perna et al.   Clinical Epigenetics

DNA methylation age is associated with mortality in a longitudinal Danish twin study

(2015) Lene Christiansen et al.   AGING CELL

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Somatic mutation in cancer and normal cells

(2015) I. Martincorena et al.   SCIENCE

DNA methylation age of blood predicts all-cause mortality in later life

(2015) Riccardo E Marioni et al.   GENOME BIOLOGY

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Revised International Prognostic Scoring System for Myelodysplastic Syndromes

(2012) P. L. Greenberg et al.   BLOOD

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL