Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors

Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling

(2021) Daniel Hormaechea-Agulla et al.   Cell Stem Cell

PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

(2021) James S. Chavez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The MTOR signaling pathway regulates macrophage differentiation from mouse myeloid progenitors by inhibiting autophagy

(2019) Meichao Zhang et al.   Autophagy

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

(2019) Alberto Mantovani et al.   IMMUNITY

Next-generation characterization of the Cancer Cell Line Encyclopedia

(2019) Mahmoud Ghandi et al.   NATURE

Cell competition: the winners and losers of fitness selection

(2019) Sarah Bowling et al.   DEVELOPMENT

Bmi1 counteracts hematopoietic stem cell aging by repressing target genes and enforcing the stem cell gene signature

(2019) Eriko Nitta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Understanding intrinsic hematopoietic stem cell aging

(2019) Eva Mejia-Ramirez et al.   HAEMATOLOGICA

Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia

(2019) Yoon-A Kang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells

(2018) Hui Peng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PPM1D truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

(2018) Josephine D. Kahn et al.   BLOOD

Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

(2018) Robert L. Bowman et al.   Cell Stem Cell

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

(2018) Marlies Meisel et al.   NATURE

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

(2018) Amir Giladi et al.   NATURE CELL BIOLOGY

Enhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null Progenitors

(2018) Sachin Pundhir et al.   Cell Reports

Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates

(2018) Xiaorong Gu et al.   JOURNAL OF CLINICAL INVESTIGATION

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

(2018) Joanne I. Hsu et al.   Cell Stem Cell

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

(2018) Zhigang Cai et al.   Cell Stem Cell

Functional genomic landscape of acute myeloid leukaemia

(2018) Jeffrey W. Tyner et al.   NATURE

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis

(2017) Aurélie Hérault et al.   NATURE

Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia

(2017) Alyssa Carey et al.   Cell Reports

Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia

(2017) M. Ryan Corces et al.   Frontiers in Oncology

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Evolution of acute myelogenous leukemia stem cell properties after treatment and progression

(2016) T.-C. Ho et al.   BLOOD

Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions

(2016) Maren Weisser et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

(2016) Eric M. Pietras et al.   NATURE CELL BIOLOGY

Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis

(2016) Petter Säwén et al.   Cell Reports

Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation

(2016) Katie A. Matatall et al.   Cell Reports

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

(2015) Eric M. Pietras et al.   Cell Stem Cell

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors

(2015) Curtis J. Henry et al.   JOURNAL OF CLINICAL INVESTIGATION

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

(2015) Katrin Busch et al.   NATURE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Evolved Cellular Mechanisms to Respond to Genotoxic Insults: Implications for Radiation-Induced Hematologic Malignancies

(2015) Courtney J. Fleenor et al.   RADIATION RESEARCH

Contrasting Roles for C/EBPα and Notch in Irradiation-Induced Multipotent Hematopoietic Progenitor Cell Defects

(2015) Courtney Jo Fleenor et al.   STEM CELLS

Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis

(2014) Nina Cabezas-Wallscheid et al.   Cell Stem Cell

Haematopoietic stem cells require a highly regulated protein synthesis rate

(2014) Robert A. J. Signer et al.   NATURE

Clonal dynamics of native haematopoiesis

(2014) Jianlong Sun et al.   NATURE

Metabolic requirements for the maintenance of self-renewing stem cells

(2014) Keisuke Ito et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

C/EBPα Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors

(2014) Marie S. Hasemann et al.   PLoS Genetics

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence

(2013) Min Ye et al.   NATURE CELL BIOLOGY

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Monoallelic CEBPA mutations in normal karyotype acute myeloid leukemia: independent favorable prognostic factor within NPM1 mutated patients

(2012) Annika Dufour et al.   ANNALS OF HEMATOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS

(2012) L. Barreyro et al.   BLOOD

Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis

(2012) H. Guo et al.   BLOOD

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Aging of the Microenvironment Influences Clonality in Hematopoiesis

(2012) Virag Vas et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

TNF  facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms

(2011) A. G. Fleischman et al.   BLOOD

mTORC1 signaling governs hematopoietic stem cell quiescence

(2011) Boyi Gan et al.   CELL CYCLE

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition

(2010) Tanya Bondar et al.   Cell Stem Cell

Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms

(2010) T. Ernst et al.   HAEMATOLOGICA

Prognostic Significance ofCEBPAMutations in a Large Cohort of Younger Adult Patients With Acute Myeloid Leukemia: Impact of DoubleCEBPAMutations and the Interaction WithFLT3andNPM1Mutations

(2010) Claire L. Green et al.   JOURNAL OF CLINICAL ONCOLOGY

Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis

(2010) C. J. Henry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Irradiation Selects for p53-Deficient Hematopoietic Progenitors

(2010) Andriy Marusyk et al.   PLOS BIOLOGY

Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-Initiating Cells in C/EBPα Mutant AML

(2009) Oxana Bereshchenko et al.   CANCER CELL

Irradiation Alters Selection for Oncogenic Mutations in Hematopoietic Progenitors

(2009) A. Marusyk et al.   CANCER RESEARCH

IL-1R Type I-Dependent Hemopoietic Stem Cell Proliferation Is Necessary for Inflammatory Granulopoiesis and Reactive Neutrophilia

(2009) Yoshihiro Ueda et al.   JOURNAL OF IMMUNOLOGY

Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

(2008) Peggy Kirstetter et al.   CANCER CELL

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity

(2008) Elisa Laurenti et al.   Cell Stem Cell