The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice

Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis

(2020) Anita A. Pinar et al.   PHARMACOLOGY & THERAPEUTICS

Multiple Somatic Mutations for Clonal Hematopoiesis Are Associated with Increased Mortality in Patients with Chronic Heart Failure

(2020) Sebastian Cremer et al.   Circulation-Genomic and Precision Medicine

The cancer patient and cardiology

(2020) José Luis Zamorano et al.   EUROPEAN JOURNAL OF HEART FAILURE

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

(2020) Alexander G. Bick et al.   NATURE

Cancer therapy shapes the fitness landscape of clonal hematopoiesis

(2020) Kelly L. Bolton et al.   NATURE GENETICS

Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure

(2020) Wesley Tyler Abplanalp et al.   CIRCULATION RESEARCH

Tissue Resident CCR2− and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury

(2019) Geetika Bajpai et al.   CIRCULATION RESEARCH

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage

(2019) Alanna M. Cameron et al.   NATURE IMMUNOLOGY

Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response

(2019) Giulia Schiroli et al.   Cell Stem Cell

Accumulation of cytoplasmic DNA due to ATM deficiency activates the microglial viral response system with neurotoxic consequences

(2019) Xuan Song et al.   JOURNAL OF NEUROSCIENCE

Wnt5a-Mediated Neutrophil Recruitment Has an Obligatory Role in Pressure Overload–Induced Cardiac Dysfunction

(2019) Ying Wang et al.   CIRCULATION

Cardiovascular Disease, Aging, and Clonal Hematopoiesis

(2019) Megan A. Evans et al.   Annual Review of Pathology-Mechanisms of Disease

Genetic IL-6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis

(2019) Alexander G. Bick et al.   CIRCULATION

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models

(2019) Soichi Sano et al.   Jove-Journal of Visualized Experiments

PPM1D truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

(2018) Josephine D. Kahn et al.   BLOOD

CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular DiseaseNovelty and Significance

(2018) Soichi Sano et al.   CIRCULATION RESEARCH

CXCL1–CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration

(2018) Lei Wang et al.   EUROPEAN HEART JOURNAL

Phosphatase wild-type p53-induced phosphatase 1 controls the development of T H 9 cells and allergic airway inflammation

(2018) Peng Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

(2018) Soichi Sano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

(2018) Emma Haapaniemi et al.   NATURE MEDICINE

Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations

(2018) Po-Ru Loh et al.   NATURE

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

(2018) Joanne I. Hsu et al.   Cell Stem Cell

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

(2018) Zhigang Cai et al.   Cell Stem Cell

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure

(2018) Lena Dorsheimer et al.   JAMA Cardiology

Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma

(2017) Christopher J. Gibson et al.   JOURNAL OF CLINICAL ONCOLOGY

Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation

(2017) R. Coleman Lindsley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

(2017) José J. Fuster et al.   SCIENCE

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury

(2016) Bo Hu et al.   SCIENCE

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

(2016) Andrew L. Young et al.   Nature Communications

NBS1 is required for macrophage homeostasis and functional activity in mice

(2015) S. Pereira-Lopes et al.   BLOOD

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia

(2014) Terrence N. Wong et al.   NATURE

Age-related mutations associated with clonal hematopoietic expansion and malignancies

(2014) Mingchao Xie et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway

(2012) M A Kang et al.   Cell Death & Disease

CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosis

(2011) Jing Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Angiotensin II revisited: new roles in inflammation, immunology and aging

(2010) Ariela Benigni et al.   EMBO Molecular Medicine

WIP1 phosphatase is a negative regulator of NF-κB signalling

(2009) Joanne Chew et al.   NATURE CELL BIOLOGY