mTOR Signaling in Parkinson’s Disease

Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL

(2016) Yan Chen Shang et al.   Aging-US

Programming Apoptosis and Autophagy with Novel Approaches for Diabetes Mellitus

(2015) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease

(2015) Zaijun Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacologic agents targeting autophagy

(2015) Helin Vakifahmetoglu-Norberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

(2015) Benjamin Dehay et al.   LANCET NEUROLOGY

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease

(2015) Ulrika Nordström et al.   NEUROBIOLOGY OF DISEASE

mTOR in Brain Physiology and Pathologies

(2015) Joël Bockaert et al.   PHYSIOLOGICAL REVIEWS

Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy

(2015) Changyoun Kim et al.   Cell Reports

Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson’s Disease

(2015) Anke A. Dijkstra et al.   PLoS One

High Glucose Condition Induces Autophagy in Endothelial Progenitor Cells Contributing to Angiogenic Impairment

(2014) Kyeong-A Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells

(2014) Hee Ju Kim et al.   Biomolecules & Therapeutics

Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease

(2014) Yijiao Xu et al.   CELLULAR SIGNALLING

Tnfaip8 l1/Oxi-β binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model

(2014) Ji-Young Ha et al.   JOURNAL OF NEUROCHEMISTRY

Corynoxine, a Natural Autophagy Enhancer, Promotes the Clearance of Alpha-Synuclein via Akt/mTOR Pathway

(2014) Lei-Lei Chen et al.   Journal of Neuroimmune Pharmacology

Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives

(2014) Anthony H V Schapira et al.   LANCET

Overexpression of Human E46K Mutant α-Synuclein Impairs Macroautophagy via Inactivation of JNK1-Bcl-2 Pathway

(2014) Jia-Qing Yan et al.   MOLECULAR NEUROBIOLOGY

Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries

(2014) Venkata Prasuja Nakka et al.   MOLECULAR NEUROBIOLOGY

PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways

(2014) Xiaoxing Xiong et al.   NEUROBIOLOGY OF DISEASE

Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

(2014) Qian Zhou et al.   TOXICOLOGICAL SCIENCES

Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson’s disease

(2014) J Romaní-Aumedes et al.   Cell Death & Disease

Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation

(2014) B I Pérez-Revuelta et al.   Cell Death & Disease

Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes

(2014) Yu-Mi Lim et al.   Nature Communications

Impairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in mice

(2014) Arnaud Francois et al.   Molecular Brain

mTOR in aging, metabolism, and cancer

(2013) Marion Cornu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Parkinson disease: from pathology to molecular disease mechanisms

(2013) David T. Dexter et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of thioredoxin-1 in suppression of endoplasmic reticulum stress in Parkinson disease

(2013) Xian-Si Zeng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress

(2013) Sarah Ciccone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells

(2013) An-Guo Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy

(2013) Tian-Fang Jiang et al.   Journal of Neuroimmune Pharmacology

Ubiquitin Hydrolase UCH-L1 Destabilizes mTOR Complex 1 by Antagonizing DDB1-CUL4-Mediated Ubiquitination of Raptor

(2013) Sajjad Hussain et al.   MOLECULAR AND CELLULAR BIOLOGY

Neurodegeneration in Parkinson's Disease: Interactions of Oxidative Stress, Tryptophan Catabolites and Depression with Mitochondria and Sirtuins

(2013) George Anderson et al.   MOLECULAR NEUROBIOLOGY

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Guide to Neurotoxic Animal Models of Parkinson's Disease

(2013) K. Tieu   Cold Spring Harbor Perspectives in Medicine

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Wnt1 Inducible Signaling Pathway Protein 1 (WISP1) Targets PRAS40 to Govern β-Amyloid Apoptotic Injury of Microglia

(2012) Yan Chen Shang et al.   CURRENT NEUROVASCULAR RESEARCH

Mapping Autophagy on to Your Metabolic Radar

(2012) E. Yamada et al.   DIABETES

Dissociation of Bcl-2-Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes

(2012) C. He et al.   DIABETES

Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment

(2012) Jason R. Cannon et al.   EXPERIMENTAL NEUROLOGY

Mechanistic Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation Is Governed by Competition between Substrates for Interaction with Raptor

(2012) Michael D. Dennis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling

(2012) Senthil Selvaraj et al.   JOURNAL OF CLINICAL INVESTIGATION

Conditional Expression of Parkinson's Disease-Related Mutant  -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1

(2012) X. Lin et al.   JOURNAL OF NEUROSCIENCE

Cooperative action of JNK and AKT/mTOR in 1-methyl-4-phenylpyridinium-induced autophagy of neuronal PC12 cells

(2012) Jezabel Rodríguez-Blanco et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity

(2012) Jae-Kyo Jeong et al.   NEUROSCIENCE RESEARCH

Paraquat, but Not Maneb, Induces Synucleinopathy and Tauopathy in Striata of Mice through Inhibition of Proteasomal and Autophagic Pathways

(2012) Jonathan Wills et al.   PLoS One

Differential Effects of UCHL1 Modulation on Alpha-Synuclein in PD-Like Models of Alpha-Synucleinopathy

(2012) Anna E. Cartier et al.   PLoS One

PRAS40 Is an Integral Regulatory Component of Erythropoietin mTOR Signaling and Cytoprotection

(2012) Zhao Zhong Chong et al.   PLoS One

mTOR: on target for novel therapeutic strategies in the nervous system

(2012) Kenneth Maiese et al.   TRENDS IN MOLECULAR MEDICINE

Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration

(2011) Sang Ryong Kim et al.   ANNALS OF NEUROLOGY

Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing

(2011) Valerie Cullen et al.   ANNALS OF NEUROLOGY

Parkinson's Disease: Genetics and Pathogenesis

(2011) Joshua M. Shulman et al.   Annual Review of Pathology-Mechanisms of Disease

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

(2011) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways

(2011) P. Gulhati et al.   CANCER RESEARCH

mTOR complex 2 signaling and functions

(2011) Won Jun Oh et al.   CELL CYCLE

Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions

(2011) Laura Magri et al.   Cell Stem Cell

Proline-rich Akt substrate of 40kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway

(2011) Haitao Wang et al.   CELLULAR SIGNALLING

Mitochondria: The Common Upstream Driver of Amyloid-β and Tau Pathology in Alzheimers Disease

(2011) D. F.F. Silva et al.   Current Alzheimer Research

NMNAT Expression and its Relation to NAD Metabolism

(2011) H. N. Jayaram et al.   CURRENT MEDICINAL CHEMISTRY

Erythropoietin and Wnt1 Govern Pathways of mTOR, Apaf-1, and XIAP in Inflammatory Microglia

(2011) Yan Chen Shang et al.   CURRENT NEUROVASCULAR RESEARCH

Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models

(2011) Andrii Domanskyi et al.   FASEB JOURNAL

Autophagy deregulation in neurodegenerative diseases - recent advances and future perspectives

(2011) Zelda H. Cheung et al.   JOURNAL OF NEUROCHEMISTRY

Nucleolar Disruption in Dopaminergic Neurons Leads to Oxidative Damage and Parkinsonism through Repression of Mammalian Target of Rapamycin Signaling

(2011) C. Rieker et al.   JOURNAL OF NEUROSCIENCE

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA–induced dyskinesia

(2011) Srinivasa Subramaniam et al.   NATURE NEUROSCIENCE

Evaluation of Markers of Oxidative Stress, Antioxidant Function and Astrocytic Proliferation in the Striatum and Frontal Cortex of Parkinson’s Disease Brains

(2011) Rajeswara Babu Mythri et al.   NEUROCHEMICAL RESEARCH

FLZ protects dopaminergic neuron through activating protein kinase B/mammalian target of rapamycin pathway and inhibiting RTP801 expression in Parkinson's disease models

(2011) X.-Q. Bao et al.   NEUROSCIENCE

Calcium Signaling Is Involved in Cadmium-Induced Neuronal Apoptosis via Induction of Reactive Oxygen Species and Activation of MAPK/mTOR Network

(2011) Baoshan Xu et al.   PLoS One

Lysosomal membrane permeabilization in Parkinson disease

(2010) Miquel Vila et al.   Autophagy

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Oxidative stress: Biomarkers and novel therapeutic pathways

(2010) Kenneth Maiese et al.   EXPERIMENTAL GERONTOLOGY

Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death

(2010) Long Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1

(2010) Hitoshi Murata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

(2010) Long Chen et al.   LABORATORY INVESTIGATION

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein

(2009) Wai Haung Yu et al.   AMERICAN JOURNAL OF PATHOLOGY

Rapamycin inhibits mTORC1, but not completely

(2009) Carson C. Thoreen et al.   Autophagy

Signaling Events Downstream of Mammalian Target of Rapamycin Complex 2 Are Attenuated in Cells and Tumors Deficient for the Tuberous Sclerosis Complex Tumor Suppressors

(2009) J. Huang et al.   CANCER RESEARCH

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

The role of local protein synthesis and degradation in axon regeneration

(2009) Laura F. Gumy et al.   EXPERIMENTAL NEUROLOGY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death

(2009) Kyou-Chan Choi et al.   JOURNAL OF NEUROCHEMISTRY

RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

(2009) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

(2009) Luke S Tain et al.   NATURE NEUROSCIENCE

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

Rapamycin protects against rotenone-induced apoptosis through autophagy induction

(2009) T. Pan et al.   NEUROSCIENCE

Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia

(2009) E. Santini et al.   Science Signaling

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Targets for neuroprotection in Parkinson's disease

(2008) Talene A. Yacoubian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

(2008) Yuzuru Imai et al.   EMBO JOURNAL

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis

(2008) Long Chen et al.   JOURNAL OF NEUROCHEMISTRY

The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

(2008) J. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement

(2008) Tianhong Pan et al.   NEUROBIOLOGY OF DISEASE

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

(2008) A. Y. Choo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of mTOR in physiology and pathology of the nervous system

(2007) Lukasz Swiech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS