Article
Neurosciences
Jeffery A. Boychuk, Corwin R. Butler, Katalin Cs. Smith, Miklos B. Halmos, Bret N. Smith
Summary: This study provides a detailed analysis of GABA(A)R signaling in mouse dentate granule cells (DGCs) after brain injury. The researchers observed that DGCs on the same side as the injury were more responsive to GABA(A)R signaling and that the drug Zolpidem can modify this signaling. Additionally, there were no changes in gene expression of GABA(A)R subunits after brain injury.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2022)
Review
Clinical Neurology
Bahar Roustaei, Somayeh Zarezadeh, Ali Akbar Ghotbi-Ravandi
Summary: Epilepsy is a common neurological disease globally affecting millions of people. Traditional medications have limitations and adverse effects, leading to the search for safer and more efficient therapies. Medicinal plants and their essential oils have shown potential as alternative treatments with fewer side effects. This review focuses on identifying plants with antiepileptic effects, particularly those that affect GABA receptors, to aid in the development of alternative drugs.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Yilun Chen, Songlu Li, Wendong Ge, Jin Jing, Hsin Yi Chen, Daniel Doherty, Alison Herman, Safa Kaleem, Kan Ding, Gamaleldin Osman, Christa B. Swisher, Christine Smith, Carolina B. Maciel, Ayham Alkhachroum, Jong Woo Lee, Monica B. Dhakar, Emily J. Gilmore, Adithya Sivaraju, Lawrence J. Hirsch, Sacit B. Omay, Hal Blumenfeld, Kevin N. Sheth, Aaron F. Struck, Brian L. Edlow, M. Brandon Westover, Jennifer A. Kim
Summary: This study evaluated the contribution of quantitative electroencephalograms in predicting post-traumatic epilepsy (PTE) and found that these features enhance the predictive value of PTE1, especially when combined with TBI mechanism and CT abnormalities. Future research should validate these findings.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Anastasia A. Vasilieva, Elena E. Timechko, Kristina D. Lysova, Anastasia I. Paramonova, Alexey M. Yakimov, Elena A. Kantimirova, Diana V. Dmitrenko
Summary: Structural or post-traumatic epilepsy often develops after brain tissue damage caused by traumatic brain injury, stroke, infections of the brain, etc. MicroRNAs, such as miR-21, miR-181a, and miR-155, show potential as biomarkers for predicting epileptogenesis. However, more in-depth and prolonged studies are needed to understand the process of epileptogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Martin Field, Istvan P. Lukacs, Emily Hunter, Richard Stacey, Puneet Plaha, Laurent Livermore, Olaf Ansorge, Peter Somogyi
Summary: The study found that specific types of interneurons in the human neocortex, such as rosehip cells and layer 2-3 innervating cells, exhibit larger tonic GABA(A) receptor currents compared to other interneuron types, potentially allowing for selective modulation of cortical circuitry. Patient parameters like age, seizures, cancer type, and anticonvulsant treatment were also examined for their potential influence on tonic inhibitory currents in human neurons.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Clinical Neurology
Lei Sun, Wei Shan, Huajun Yang, Ru Liu, Jianping Wu, Qun Wang
Summary: Post-traumatic epilepsy is a serious consequence of traumatic brain injury, and inflammation plays a significant role in epileptogenesis. Understanding the contribution of neuroinflammation to the development of PTE is crucial, requiring further research.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jun Wu, Zhipeng Hou, Yan Wang, Liping Chen, Chengxi Lian, Qingfei Meng, Chaoying Zhang, Xiufen Li, Longjiang Huang, Haibo Yu
Summary: A series of 7-alkoxy -[1,2,4] triazolo [1, 5-a] pyrimidine derivatives were synthesized and found to exhibit significant anti-seizure effects. The compounds mainly exerted their anticonvulsant activity by allosteric potentiation of GABA(A) receptors. Compound 10c, with potent activity, showed sensitivity to different subunit configurations of GABA(A) receptors and acted on distinct sites from benzodiazepines and barbiturates. These structural compounds may serve as a foundation for designing novel antiepileptic molecules.
BIOORGANIC CHEMISTRY
(2022)
Article
Clinical Neurology
Hosseinali Khalili, Nima Rahimi Kashkooli, Amin Niakan, Ali A. Asadi-Pooya
Summary: The study aimed to investigate risk factors for post-traumatic epilepsy (PTE) after severe non-penetrating civilian traumatic brain injury (TBI), finding a significant association between higher Glasgow outcome scale (extended) at discharge and decreased risk of PTE.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Clinical Neurology
Eppu Manninen, Karthik Chary, Niina Lapinlampi, Pedro Andrade, Tomi Paananen, Alejandra Sierra, Jussi Tohka, Olli Grohn, Asla Pitkanen
Summary: This study aimed to identify MRI biomarkers for post-traumatic epilepsy in Sprague-Dawley rats with traumatic brain injury. The researchers found that a combination of T-2 relaxation time and diffusion tensor data could distinguish rats with and without epilepsy, and even a single time-point measurement could significantly enrich the epilepsy rate within the study population.
Article
Neurosciences
Marcin Wyroslak, Katarzyna Lebida, Jerzy W. Mozrzymas
Summary: The study examined the plasticity of tonic inhibition in hippocampal pyramidal neurons under NMDAR-dependent GABAergic inhibitory long-term potentiation (iLTP) induction protocol. It was found that alpha 5-containing GABA(A)Rs played a key role in mediating the plastic change in tonic current during this process.
Article
Biochemistry & Molecular Biology
Tabea Kuerten, Natascha Ihbe, Timo Ueberbach, Ute Distler, Malte Sielaff, Stefan Tenzer, Thomas Mittmann
Summary: Posttraumatic epilepsy (PTE) is a major public health concern and contributes significantly to global epilepsy cases. This study explores the role of the GABA(A)-stabilizing protein ubqln1 in mouse models of traumatic brain injury (TBI) and in vitro epilepsy. The findings suggest that ubqln1 and monoamine transmitter systems play a role in cortical network activity during posttraumatic epileptogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Marcin Wyroslak, Grzegorz Dobrzanski, Jerzy W. Mozrzymas
Summary: In this study, we investigated the effect of NMDA-induced plasticity on tonic inhibition in somatostatin- and parvalbumin-containing interneurons. Our results showed that NMDA application enhanced tonic conductance in somatostatin-containing interneurons, while reducing tonic inhibition in both fast-spiking and non-fast-spiking parvalbumin-positive cells. These changes were associated with alterations in the content of α5 and δ-subunit-containing GABA(A) receptors.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Phat Chang, Hua Xie, Venkata Sita Priyanka Illapani, Xiaozhen You, Tayyba Anwar, Archana Pasupuleti, Thuy-Anh Vu, L. Gilbert Vezina, Taha Gholipour, Chima O. Oluigbo, Anqing Zhang, William Davis Gaillard, Nathan T. T. Cohen
Summary: This study found that children with FCD-related epilepsy and FTBTC seizures are more likely to develop pharmacoresistant epilepsy. The presence of FTBTC seizures is associated with worse surgical outcomes, possibly due to interactions between the lesion and restricted cortical neural networks. These findings are significant for identifying children with FCD-related epilepsy at high risk of PRE and considering potentially curative surgery earlier.
Article
Chemistry, Multidisciplinary
Jun Wu, Miao Zhao, Yu-chen Jin, Min Li, Ke-xin Yu, Hai-bo Yu
Summary: This study investigated the antiseizure effect of Schisandrin B (SchB) in mouse models of seizure and explored its underlying mechanisms. The results showed that SchB exhibited therapeutic potential in various mouse models of seizure and acted as a positive allosteric modulator of GABA(A)Rs and GlyRs.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Neurosciences
Ruth Westenbroek, Joshua Kaplan, Katie Viray, Nephi Stella
Summary: The study uncovers the molecular mechanism behind the therapeutic response of ABHD6 inhibition in reducing seizures. It shows that reducing ABHD6 activity can decrease the premature lethality and thermally induced seizures in a genetic mouse model of Dravet Syndrome. The mechanism involves the potentiation of extrasynaptic GABAAR currents without affecting synaptic GABAAR currents. This discovery provides insights for developing targeted therapies for controlling hippocampal hyperexcitability in Dravet Syndrome.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Ahmed T. Hussin, Jeffery A. Boychuk, Andrew R. Brown, Quentin J. Pittman, G. Campbell Teskey
Editorial Material
Biochemistry & Molecular Biology
Jeffery A. Boychuk, G. Campbell Teskey
Article
Neurosciences
Corwin R. Butler, Jeffery A. Boychuk, Bret N. Smith
EXPERIMENTAL NEUROLOGY
(2016)
Article
Neurosciences
Jeffery A. Boychuk, Jordan S. Farrell, Laura A. Palmer, Anna C. Singleton, Quentin J. Pittman, G. Campbell Teskey
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Multidisciplinary Sciences
Carle R. Boychuk, Katalin Cs Smith, Laura E. Peterson, Jeffery A. Boychuk, Corwin R. Butler, Isabel D. Derera, John J. McCarthy, Bret N. Smith
SCIENTIFIC REPORTS
(2019)
Article
Clinical Neurology
Corwin R. Butler, Jeffery A. Boychuk, Francois Pomerleau, Ramona Alcala, Peter Huettl, Yi Ai, Johan Jakobsson, Sidney W. Whiteheart, Greg A. Gerhardt, Bret N. Smith, John T. Slevin
Article
Neurosciences
Corwin R. Butler, Gary L. Westbrook, Eric Schnell
Summary: This study examines the role of mossy cells in the hippocampus after epilepsy. The results show that mossy cell density and excitation of dentate granule cells are reduced in pilocarpine-treated mice, but the excitation of parvalbumin-positive basket cells is maintained.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Corwin R. Butler, Jeffery A. Boychuk, Bret N. Smith
Article
Clinical Neurology
Jeffery A. Boychuk, Susan C. Schwerin, Nagheme Thomas, Alexandra Roger, Geoffrey Silvera, Misha Liverpool, DeAnna L. Adkins, Jeffrey A. Kleim
NEUROREHABILITATION AND NEURAL REPAIR
(2016)
Article
Neurosciences
Corwin R. Butler, Jeffery A. Boychuk, Bret N. Smith
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2015)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)