Epac, a positive or negative signaling molecule in cardiovascular diseases
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Title
Epac, a positive or negative signaling molecule in cardiovascular diseases
Authors
Keywords
Epac, Cardiovascular diseases, Myocardial fibrosis, Myocardial hypertrophy, Cardiomyocyte apoptosis
Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 148, Issue -, Pages 112726
Publisher
Elsevier BV
Online
2022-02-17
DOI
10.1016/j.biopha.2022.112726
References
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Note: Only part of the references are listed.- Vitexin regulates EPAC and NLRP3 and ameliorates chronic cerebral hypoperfusion injury
- (2021) Qilong Zhang et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression
- (2021) Michael Wagner et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Phosphodiesterase 4 inhibition restrains muscle proteolysis in diabetic rats by activating PKA and EPAC/Akt effectors and inhibiting FoxO factors
- (2021) Carlos Alberto Arcaro et al. LIFE SCIENCES
- Improved biotechnological production of paclitaxel in Taxus media cell cultures by the combined action of coronatine and calix[8]arenes
- (2021) Ainoa Escrich et al. PLANT PHYSIOLOGY AND BIOCHEMISTRY
- Intracellular receptor EPAC regulates von Willebrand factor secretion from endothelial cells in a PI3K-/eNOS-dependent manner during inflammation
- (2021) Jie Xiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Long Noncoding RNAs Involved in Cardiomyocyte Apoptosis Triggered by Different Stressors
- (2021) Jinghui Sun et al. Journal of Cardiovascular Translational Research
- Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling
- (2020) Hua Liu et al. Science Advances
- Stimulation of GLP-1 Receptor Inhibits Methylglyoxal-Induced Mitochondrial Dysfunctions in H9c2 Cardiomyoblasts: Potential Role of Epac/PI3K/Akt Pathway
- (2020) Narawat Nuamnaichati et al. Frontiers in Pharmacology
- EPAC in Vascular Smooth Muscle Cells
- (2020) Nadine Wehbe et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels
- (2020) Jennifer van der Horst et al. Frontiers in Physiology
- Epac1 (Exchange Protein Directly Activated by cAMP 1) Upregulates LOX-1 (Oxidized Low-Density Lipoprotein Receptor 1) to Promote Foam Cell Formation and Atherosclerosis Development
- (2020) William G. Robichaux et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Protein kinase A inhibitor proteins (PKIs) divert GPCR‐Gαs‐cAMP signaling toward EPAC and ERK activation and are involved in tumor growth
- (2020) James J. Hoy et al. FASEB JOURNAL
- Late sodium current and calcium homeostasis in arrhythmogenesis
- (2020) Kornél Kistamás et al. Channels
- Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis
- (2019) Xi He et al. LIFE SCIENCES
- Deletion of Osteopontin Enhances β2-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes
- (2019) Celina Pollard et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Dysfunctional EAT thickness may promote maladaptive heart remodeling in CVD patients through the ST2-IL33 system, directly related to EPAC protein expression
- (2019) Elena Vianello et al. Scientific Reports
- Differences in the cargos and functions of exosomes derived from six cardiac cell types: a systematic review
- (2019) Ming-yue Xu et al. Stem Cell Research & Therapy
- cAMP/EPAC Signaling Enables ETV2 to Induce Endothelial Cells with High Angiogenesis Potential
- (2019) Jae-Jun Kim et al. MOLECULAR THERAPY
- Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy
- (2019) Kathrine Sivertsen Åsrud et al. Scientific Reports
- Ending Restenosis: Inhibition of Vascular Smooth Muscle Cell Proliferation by cAMP
- (2019) Smith et al. Cells
- The Role of Cyclic AMP Signaling in Cardiac Fibrosis
- (2019) Marion Delaunay et al. Cells
- PDE/cAMP/Epac/C/EBP-β Signaling Cascade Regulates Mitochondria Biogenesis of Tubular Epithelial Cells in Renal Fibrosis
- (2018) Hao Ding et al. ANTIOXIDANTS & REDOX SIGNALING
- Exchange-protein activated by cyclic-AMP (EPAC) regulates atrial fibroblast function and controls cardiac remodeling
- (2018) Sirirat Surinkaew et al. CARDIOVASCULAR RESEARCH
- Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes
- (2018) Craig A. Nash et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Cyclic 3′,5′-adenosine monophosphate (cAMP) signaling in the anterior pituitary gland in health and disease
- (2018) Laura C. Hernández-Ramírez et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Epac is required for exogenous and endogenous stimulation of adenosine A2B receptor for inhibition of angiotensin II-induced collagen synthesis and myofibroblast differentiation
- (2018) Sarawuth Phosri et al. Purinergic Signalling
- Ginseng Compatibility Environment Attenuates Toxicity and Keeps Efficacy in Cor Pulmonale Treated by Fuzi Beimu Incompatibility Through the Coordinated Crosstalk of PKA and Epac Signaling Pathways
- (2018) Yingying Huang et al. Frontiers in Pharmacology
- Crosstalk between the TGF-β and WNT signalling pathways during cardiac fibrogenesis
- (2018) Edyta Działo et al. ACTA BIOCHIMICA POLONICA
- Cardiac fibrosis: new insights into the pathogenesis
- (2018) Zhen-Guo Ma et al. International Journal of Biological Sciences
- β-adrenergic regulation of late Na+ current during cardiac action potential is mediated by both PKA and CaMKII
- (2018) Bence Hegyi et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Spices and Atherosclerosis
- (2018) Pi-Fen Tsui et al. Nutrients
- Calcium/calmodulin-dependent kinase 2 mediates Epac-induced spontaneous transient outward currents in rat vascular smooth muscle
- (2017) Edward S. A. Humphries et al. JOURNAL OF PHYSIOLOGY-LONDON
- In vitro models of the cardiac microenvironment to study myocyte and non-myocyte crosstalk: bioinspired approaches beyond the polystyrene dish
- (2017) Celinda M. Kofron et al. JOURNAL OF PHYSIOLOGY-LONDON
- Epidemiology of cardiovascular disease in young individuals
- (2017) Charlotte Andersson et al. Nature Reviews Cardiology
- EPAC1 overexpression is a prognostic marker and its inhibition shows promising therapeutic potential for gastric cancer
- (2017) Ding-Ping Sun et al. ONCOLOGY REPORTS
- Research Opportunities and Challenges in the Era of Healthy Living Medicine: Unlocking the Potential
- (2017) Shane A. Phillips et al. PROGRESS IN CARDIOVASCULAR DISEASES
- Extracellular Vesicles in Cardiovascular Theranostics
- (2017) Yihua Bei et al. Theranostics
- Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway
- (2017) Sarawuth Phosri et al. Frontiers in Pharmacology
- The interaction between a HSP-70 gene variant with dietary calories in determining serum markers of inflammation and cardiovascular risk
- (2017) Mehrane Mehramiz et al. CLINICAL NUTRITION
- Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat ArteriesHighlights
- (2016) Jennifer B. Stott et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction
- (2016) Wenqian Cai et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Calmodulin kinase II inhibition limits the pro-arrhythmic Ca2+waves induced by cAMP-phosphodiesterase inhibitors
- (2016) Pierre Bobin et al. CARDIOVASCULAR RESEARCH
- Cyclic AMP Sensor EPAC Proteins and Their Role in Cardiovascular Function and Disease
- (2016) Frank Lezoualc’h et al. CIRCULATION RESEARCH
- Role of EPAC in cAMP-Mediated Actions in Adrenocortical Cells
- (2016) Aurélia E. Lewis et al. Frontiers in Endocrinology
- Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury
- (2016) Hui Wang et al. Scientific Reports
- Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal FormationSignificance
- (2015) Yuko Kato et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- The cAMP-producing agonist beraprost inhibits human vascular smooth muscle cell migration via exchange protein directly activated by cAMP
- (2015) Jenny S. McKean et al. CARDIOVASCULAR RESEARCH
- The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal
- (2015) Euan Parnell et al. CELLULAR SIGNALLING
- Depotentiation of intact rat cardiac muscle unmasks an Epac-dependent increase in myofilament Ca2+sensitivity
- (2015) Sarbjot Kaur et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Epac is Required for GLP-1R-Mediated Inhibition of Oxidative Stress and Apoptosis in Cardiomyocytes
- (2015) Supachoke Mangmool et al. MOLECULAR ENDOCRINOLOGY
- β-adrenergic stimulation activates protein kinase Cε and induces extracellular signal-regulated kinase phosphorylation and cardiomyocyte hypertrophy
- (2015) LIN LI et al. Molecular Medicine Reports
- Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes
- (2015) Laëtitia Pereira et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tubulin polymerization disrupts cardiac β-adrenergic regulation of late INa
- (2014) Nataliya Dybkova et al. CARDIOVASCULAR RESEARCH
- Exchange Protein Directly Activated by cAMP Mediates Slow Delayed-Rectifier Current Remodeling by Sustained β-Adrenergic Activation in Guinea Pig Hearts
- (2014) Mona Aflaki et al. CIRCULATION RESEARCH
- The GLP-1 Analogue Liraglutide Protects Cardiomyocytes from High Glucose-induced Apoptosis by Activating the Epac-1/Akt Pathway
- (2014) X.-M. Wu et al. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
- Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses
- (2014) Satoshi Okumura et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells
- (2014) Tomomi E. Kimura et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Epac contributes to cardiac hypertrophy and amyloidosis induced by radiotherapy but not fibrosis
- (2014) Virginie Monceau et al. RADIOTHERAPY AND ONCOLOGY
- PKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production
- (2014) Verónica García-Morales et al. VASCULAR PHARMACOLOGY
- Ca2+ Fluxes Involvement in Gene Expression During Cardiac Hypertrophy
- (2013) Ana Gomez et al. Current Vascular Pharmacology
- Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction
- (2013) Magdalena Chrzanowska-Wodnicka EXPERIMENTAL CELL RESEARCH
- Contribution of K v 7 Channels to Basal Coronary Flow and Active Response to Ischemia
- (2013) Saereh Khanamiri et al. HYPERTENSION
- Epac activator critically regulates action potential duration by decreasing potassium current in rat adult ventricle
- (2013) Fabien Brette et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms
- (2013) Erling A. Hoivik et al. PLoS One
- Structural Dynamics and Topology of Phosphorylated Phospholamban Homopentamer Reveal Its Role in the Regulation of Calcium Transport
- (2013) Vitaly V. Vostrikov et al. STRUCTURE
- Redox Regulation of Sodium and Calcium Handling
- (2012) Stefan Wagner et al. ANTIOXIDANTS & REDOX SIGNALING
- cAMP-dependent allostery and dynamics in Epac: an NMR view
- (2012) Rajeevan Selvaratnam et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Sustained Epac activation induces calmodulin dependent positive inotropic effect in adult cardiomyocytes
- (2012) Gema Ruiz-Hurtado et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Epac in cardiac calcium signaling
- (2012) Gema Ruiz-Hurtado et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Structural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMP
- (2012) Mark A. White et al. PLoS One
- The Auto-Inhibitory Role of the EPAC Hinge Helix as Mapped by NMR
- (2012) Rajeevan Selvaratnam et al. PLoS One
- KCNE Regulation of K+ Channel Trafficking – a Sisyphean Task?
- (2012) Vikram A. Kanda et al. Frontiers in Physiology
- The cAMP-responsive Rap1 Guanine Nucleotide Exchange Factor, Epac, Induces Smooth Muscle Relaxation by Down-regulation of RhoA Activity
- (2011) Bartosz J. Zieba et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Epac enhances excitation–transcription coupling in cardiac myocytes
- (2011) Laetitia Pereira et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- REVIEW: Sodium Channel (Dys)Function and Cardiac Arrhythmias
- (2010) Carol Ann Remme et al. Cardiovascular Therapeutics
- A new regulation of IL-6 production in adult cardiomyocytes by β-adrenergic and IL-1β receptors and induction of cellular hypertrophy by IL-6 trans-signalling
- (2010) Nicolas Szabo-Fresnais et al. CELLULAR SIGNALLING
- Epac activation induces histone deacetylase nuclear export via a Ras-dependent signalling pathway
- (2010) Mélanie Métrich et al. CELLULAR SIGNALLING
- Mechanism of Epac Activation
- (2009) Tamara Tsalkova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Epac Mediates β-Adrenergic Receptor–Induced Cardiomyocyte Hypertrophy
- (2008) Mélanie Métrich et al. CIRCULATION RESEARCH
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