Journal
FRONTIERS IN PHYSIOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2020.00727
Keywords
Kv7 (KCNQ); cAMP; PKA; EPAC; physiology
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Funding
- Lundbeck Foundation [R307-2018-3674]
- European Union's Horizon 2020 Research and Innovation Program under theMarie Sklodowska-Curie grant [801199]
- MRC [MR/K019074/1] Funding Source: UKRI
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Voltage-gated Kv7 potassium channels, encoded byKCNQgenes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can activate numerous downstream effector proteins, generating downstream signaling pathways that regulate many functions in cells. A role for cAMP in ion channel regulation has been established, and recent findings show that cAMP signaling plays a role in Kv7 channel regulation. Although cAMP signaling is recognized to regulate Kv7 channels, the precise molecular mechanism behind the cAMP-dependent regulation of Kv7 channels is complex. This review will summarize recent research findings that support the mechanisms of cAMP-dependent regulation of Kv7 channels.
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