Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling

Activation of the Small GTPase Rap1 Inhibits Choroidal Neovascularization by Regulating Cell Junctions and ROS Generation in Rats

(2018) Jiajia Li et al.   CURRENT EYE RESEARCH

EPAC1 regulates endothelial annexin A2 cell surface translocation and plasminogen activation

(2018) Wenli Yang et al.   FASEB JOURNAL

Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development

(2018) William G. Robichaux et al.   PHYSIOLOGICAL REVIEWS

Epac1 protects the retina against ischemia/reperfusion-induced neuronal and vascular damage

(2018) Li Liu et al.   PLoS One

The EPAC–Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability

(2017) Carla J. Ramos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis

(2017) Zhiping Liu et al.   Nature Communications

Catecholamines facilitate VEGF-dependent angiogenesis via β2-adrenoceptor-induced Epac1 and PKA activation

(2017) Jaspal Garg et al.   Oncotarget

Increased microvascular permeability in mice lacking Epac1 (Rapgef3)

(2016) R. K. Kopperud et al.   Acta Physiologica

Role of Exchange Protein Directly Activated by Cyclic AMP Isoform 1 in Energy Homeostasis: Regulation of Leptin Expression and Secretion in White Adipose Tissue

(2016) Yaohua Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury

(2016) Hui Wang et al.   Scientific Reports

Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”

(2015) Yingmin Zhu et al.   Scientific Reports

cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP)

(2014) Owain Llŷr Roberts et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nontranscriptional Role of Hif-1α in Activation of γ-Secretase and Notch Signaling in Breast Cancer

(2014) Jennifer C. Villa et al.   Cell Reports

Epac2 Mediates Cardiac β1-Adrenergic–Dependent Sarcoplasmic Reticulum Ca 2+ Leak and Arrhythmia

(2013) Laëtitia Pereira et al.   CIRCULATION

Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses

(2013) B. Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial Alzheimer Disease Presenilin-1 Mutations Alter the Active Site Conformation of γ-secretase

(2012) De-Ming Chau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Epac-Rap1 Signaling Pathway Controls cAMP-mediated Exocytosis of Weibel-Palade Bodies in Endothelial Cells

(2012) Kathinka W. E. M. van Hooren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Leptin Sensitivity, Reduced Adiposity, and Improved Glucose Homeostasis in Mice Lacking Exchange Protein Directly Activated by Cyclic AMP Isoform 1

(2012) J. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Isoform-specific antagonists of exchange proteins directly activated by cAMP

(2012) T. Tsalkova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiangiogenic effects of β2-adrenergic receptor blockade in a mouse model of oxygen-induced retinopathy

(2011) Davide Martini et al.   JOURNAL OF NEUROCHEMISTRY

Use of the mouse aortic ring assay to study angiogenesis

(2011) Marianne Baker et al.   Nature Protocols

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling

(2009) Seung Namkoong et al.   CELLULAR SIGNALLING

NOTCH3 Expression Is Induced in Mural Cells Through an Autoregulatory Loop That Requires Endothelial-Expressed JAGGED1

(2009) Hua Liu et al.   CIRCULATION RESEARCH

VEGFs and receptors involved in angiogenesis versus lymphangiogenesis

(2009) Marja Lohela et al.   CURRENT OPINION IN CELL BIOLOGY

Intracellular Trafficking of Presenilin 1 Is Regulated by β-Amyloid Precursor Protein and Phospholipase D1

(2009) Yun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An exo-cell assay for examining real-time γ-secretase activity and inhibition

(2009) Christopher C Shelton et al.   Molecular Neurodegeneration

The neurovascular retina in retinopathy of prematurity

(2009) Anne B. Fulton et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Epac and PKA: a tale of two intracellular cAMP receptors

(2008) Xiaodong Cheng et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Endosomal entry regulates Notch receptor activation inDrosophila melanogaster

(2008) Thomas Vaccari et al.   JOURNAL OF CELL BIOLOGY

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

(2003) H. F. Dovey et al.   JOURNAL OF NEUROCHEMISTRY