Article
Biochemistry & Molecular Biology
Clementina Sitzia, Elena Vianello, Elena Dozio, Marta Kalousova, Tomas Zima, Stefano Brizzola, Paola Roccabianca, Gabriella Tedeschi, John Lamont, Lorenza Tacchini, Massimiliano Marco Corsi-Romanelli
Summary: Obesity is associated with cardiovascular disease and mortality, and adipose-derived IL-33 plays a role in cardiac remodeling. The dysregulation of IL-33/ST2 signaling affects Epac proteins and myocardial gene expression, leading to pro-fibrotic effects. Ghrelin-induced IL-33 secretion counteracts fibrosis and influences transcription factor expression. The effect of IL-33 signaling depends on cell types' origin and the balancing of ST2 isoforms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Geza Halasz, Francesco Bandera, Massimo F. Piepoli
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cell Biology
Paolo Molinari, Lara Caldiroli, Elena Dozio, Roberta Rigolini, Paola Giubbilini, Francesca Maria Ida Carminati, Giuseppe Castellano, Massimiliano M. Corsi M. Romanelli, Simone Vettoretti
Summary: In patients with chronic kidney disease (CKD), advanced glycation end products (AGEs) are associated with specific components of frailty, including an inverse association with BMI and a direct association with gait test time. AGEs are also associated with involuntary weight loss.
Editorial Material
Cardiac & Cardiovascular Systems
Geza Halasz, Francesco Bandera, Massimo Piepoli
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Geza Halasz, Francesco Bandera, Massimo Piepoli
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Geza Halasz, Francesco Bandera, Massimo Piepoli
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Geza Halasz, Francesco Bandera, Massimo Piepoli
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alexis Elias Malavazos, Gianluca Iacobellis, Elena Dozio, Sara Basilico, Angelica Di Vincenzo, Carola Dubini, Lorenzo Menicanti, Elena Vianello, Chiara Meregalli, Chiara Ruocco, Maurizio Ragni, Francesco Secchi, Pietro Spagnolo, Serenella Castelvecchio, Lelio Morricone, Silvio Buscemi, Antonio Giordano, Jeffrey J. Goldberger, Michele Carruba, Saverio Cinti, Massimiliano Marco Corsi Romanelli, Enzo Nisoli
Summary: Human epicardial adipose tissue (EAT) is a unique and multifunctional fat compartment of the heart that can directly interact with the myocardium. It plays a key role in the development and progression of coronary artery disease, atrial fibrillation, and heart failure. Targeting EAT through G-protein-coupled receptors, such as GLP-1R agonists, can be a novel therapeutic approach.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Francesco Bandera
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Geza Halasz, Francesco Bandera, Guido Giacalone, Massimo Piepoli
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Immunology
Laura V. Renna, Fabio Bertani, Alessandro Podio, Sara Boveri, Matteo Carrara, Arianna Pinton, Valentina Milani, Giovanni Spuria, Angelica F. Nizza, Sara Basilico, Carola Dubini, Ambra Cerri, Lorenzo Menicanti, Massimiliano M. Corsi-Romanelli, Alexis E. Malavazos, Rosanna Cardani
Summary: Accurate studies on the dynamics of Pfizer-Biontech BNT162b2-induced antibodies are crucial for tailoring booster dose administration. Little is known about the durability and kinetics of antibody titers months after receiving a booster dose. In this study, the dynamic of anti-Trimeric Spike (anti-TrimericS) IgG titer was examined in healthcare workers who had received two vaccine doses plus a booster dose. The results suggest that the booster dose increases anti-TrimericS IgG production and levels out differences in immunogenicity based on infection status, age, and sex.
Review
Biochemistry & Molecular Biology
Elena Dozio, Lara Caldiroli, Paolo Molinari, Giuseppe Castellano, Nicholas Walter Delfrate, Massimiliano Marco Corsi Romanelli, Simone Vettoretti
Summary: Advanced glycation end products (AGEs) are aging products that accumulate in chronic kidney disease (CKD) due to increased production, reduced excretion, and imbalance between oxidant/antioxidant capacities. This review aims to summarize the knowledge of AGEs in CKD onset and progression, focusing on related disorders and mortality. The role of AGEs as etiopathogenetic molecules and potential markers or therapeutic targets will be discussed.