Review
Cell Biology
Alba Guijarro-Belmar, Dominik Mateusz Domanski, Xuenong Bo, Derryck Shewan, Wenlong Huang
Summary: Traumatic spinal cord injury is a global health issue that results in permanent sensorimotor disabilities. While targeting cAMP directly has challenges, activating its downstream effector Epac2 shows promise in promoting axonal regeneration and functional improvement following injury. Further research is needed to fully understand the therapeutic potential of targeting Epac2 in traumatic spinal cord injury.
NEURAL REGENERATION RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Zeyuan Li, Bo Peng, Shilian Chen, Jiaping Li, Kai Hu, Lijuan Liao, Qiuli Xie, Mei Yao, Lixing Liang, Stephen Tomlinson, Guandou Yuan, Songqing He
Summary: This study compared the different mechanisms of liver regeneration and injury between partial hepatectomy (pHx) and extended hepatectomy (eHx) using transcriptome and metabolome analysis. The results showed that eHx caused more severe liver injury and lower survival rates compared to pHx. Analysis of differentially expressed genes (DEGs) and differentially produced metabolites (DPMs) suggested that cholesterol metabolism and insulin resistance pathways might be important for liver regeneration and mouse survival post-PHx and -eHx.
Review
Biotechnology & Applied Microbiology
Yi Wu, Ning Li, Xinyu Shu, Wang Li, Xiaoyu Zhang, Dongyuan Lu, Mian Long
Summary: The liver is a complex organ with vital functions and regenerative capacity after tissue injury. Mechanical cues play a significant role in liver regeneration, including changes in hemodynamics and mechanical forces within the liver. Understanding the mechanotransductive pathways and mechanocrine responses can contribute to a comprehensive understanding of liver regeneration. Proper adjustment of mechanical loading may serve as an effective therapy for liver injury and diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Hong Liu, Anqi Zhou, Zhiwen Fan, Xi Zhu, Xiulian Miao
Summary: This study investigated the role of ubiquitin-specific peptidase 47 (USP47) in liver regeneration. The results showed that USP47 expression was up-regulated in hepatocytes isolated from mice subjected to partial hepatectomy or exposed to HGF treatment. E2F1 was identified as the primary regulator of USP47 transcription. USP47 was found to play an essential role in liver regeneration, as its inhibition impaired liver regeneration in mice and its over-expression enhanced hepatocyte proliferation in vitro and promoted liver regeneration in mice. A positive correlation between USP47 expression and hepatocyte proliferation was also observed in patients with acute liver failure.
Article
Cell Biology
Yuan-E Lian, Yan-Nan Bai, Jian-Lin Lai, Ai-Min Huang
Summary: The study found that aberrant autophagy in fibrotic liver leads to impaired liver regeneration. Enhancement of autophagy improves hepatocyte proliferative capacity and restricts cellular hypertrophy and binuclearity ratio.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Adel Hammoutene, Marion Tanguy, Melanie Calmels, Riccardo Pravisani, Miguel Albuquerque, Christophe Casteleyn, Lotfi Slimani, Jeremy Sadoine, Chantal M. Boulanger, Valerie Paradis, Helene Gilgenkrantz, Pierre-Emmanuel Rautou
Summary: Patients with non-alcoholic fatty liver disease (NAFLD) have impaired liver regeneration due to a defect in autophagy of liver endothelial cells. This study aimed to determine the role of endothelial autophagy in liver regeneration following liver resection in NAFLD.
LIVER INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Di Wu, Yaojing Jiang, Zhihong Wang, Yunzhi Ni, Anran Ma, Yue Zhou, Rui Liu, Yan-Ru Lou, Qinghua Wang
Summary: This study investigated the metabolomic changes of regenerative islets from partial pancreatectomy (Ppx) mice and speculated the underlying mechanisms. The results showed that there were fourteen differentially changed metabolites in the islets of Ppx mice, including long-chain fatty acids and amino acid derivatives. Moreover, the cAMP signaling pathway was found to be activated in the islets from Ppx mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Runbin Sun, Haokai Zhao, Shuzhen Huang, Ran Zhang, Zhenyao Lu, Sijia Li, Guangji Wang, Jiye Aa, Yuan Xie
Summary: The study investigated the dynamic metabolic changes during liver regeneration in mice using a metabolomic approach and regression analysis with different machine learning methods. The random forest method showed the best performance in predicting liver index, with several amino acid metabolic pathways and glucose metabolism pathway being the most influenced during liver regeneration.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Chunliang Xie, Zhoumei Zhang, Manyi Yang, Cha Cao, Yingjun Zhou, Zuohua Zhu, Wenbing Gong, Chao Xu, Li Yan, Zhenxiu Hu, Lianzhong Ai, Yuande Peng
Summary: Emerging evidence suggests that probiotics, such as L. plantarum AR113, can accelerate liver regeneration by influencing gut microbial composition and metabolite levels.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Saisai Wei, Qiang Zheng, Yu Pan, Yunwan Xu, Jiacheng Tang, Xiujun Cai
Summary: The study revealed that liver regeneration leads to reprogramming of gene expression profiles, while core clock genes' rhythm remains stable. Performing partial hepatectomy in the evening may result in retarded liver regeneration due to the accumulation of DEC1.
Article
Gastroenterology & Hepatology
Genis Camprecios, Aina Anton, Anna Oncins, Carla Montironi, Maria Ruart, Rosa Montanes, Hector Garcia-Caldero, Joan Carles Garcia-Pagan, Virginia Hernandez-Gea
Summary: Liver sinusoidal endothelial cells (LSEC) are key elements in regulating the liver response to injury and regeneration. Endothelial autophagy plays a crucial role in protecting cells from injury-induced oxidative stress and fibrosis. However, this study found that endothelial autophagy is not essential for liver regeneration after partial hepatectomy (PHx).
LIVER INTERNATIONAL
(2023)
Article
Cell Biology
Lais A. de Paula Simino, Marina Figueiredo Fontana, Thais de Fante, Carolina Panzarin, Leticia Martins Ignacio-Souza, Marciane Milanski, Marcio Alberto Torsoni, Mina Desai, Michael G. Ross, Adriana Souza Torsoni
Summary: Obesity during pregnancy increases the risk of non-alcoholic fatty liver disease in offspring. However, the offspring of obese dams are able to overcome epigenetic changes and regenerate liver tissue after partial hepatectomy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Qinhui Liu, Qin Tang, Xinchun Liu, Min Tian, Xiandan Jing, Zongyun Feng, Xuping Yang
Summary: Studies have demonstrated the positive effect of highland barley ss-glucan (HBBG) on various liver diseases, including acute liver injury and liver regeneration. In this study, the researchers investigated the beneficial impact of HBBG on liver regeneration following partial hepatectomy (PH) using mouse models. They found that HBBG promoted hepatocyte proliferation and liver regeneration after PH by activating the STAT3-CyclinD1 signaling pathway. Furthermore, the intervention of HBBG decreased hepatocyte apoptosis in a liver injury model induced by CCl4.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Genetics & Heredity
Jian Zhao, Shi-Zhe Yu, Qiang Cai, Duo Ma, Long Jiang, Ling-Peng Yang, Zhi-Yong Yu
Summary: Key genes involved in cell cycle, DNA replication, and p53 signaling pathway were identified in the early stage of liver regeneration in mice after partial hepatectomy (PH). Ube2c was found to play a crucial role in regulating hepatocyte proliferation by modulating genes such as Ccna2, Cdkn1a, Chek1, and Mcm5.
FRONTIERS IN GENETICS
(2021)
Article
Microbiology
Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian, Sookja Kim Chung
Summary: Epac2(-/)(-) mice exhibit gut dysbiosis under physiological conditions, and WD feeding leads to gut microbiome imbalance in mice regardless of genotype; Epac1(-/)(-) mice show more severe inflammation and insulin resistance after WD feeding.
Article
Plant Sciences
Yagut Allahverdiyeva, Eva-Mari Aro, Bert van Bavel, Carlos Escudero, Christiane Funk, Jarna Heinonen, Lars Herfindal, Peter Lindblad, Sari Makinen, Merja Penttila, Kaarina Sivonen, Matilde Skogen Chauton, Hanne Skomedal, Jorunn Skjermo
Summary: NordAqua is a Nordic Center of Excellence focused on promoting Blue Bioeconomy and reforming the use of natural resources sustainably. Their key research includes improving photosynthesis, developing novel photosynthetic cell factories, promoting diversity of Nordic cyanobacteria and algae, and improving bio-based wastewater purification technologies.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Plant Sciences
David P. Fewer, Jouni Jokela, Lassi Heinila, Reidun Aesoy, Kaarina Sivonen, Tomas Galica, Pavel Hrouzek, Lars Herfindal
Summary: Cyanobacteria produce diverse cyclic lipopeptides with potent antifungal activities, targeting a range of human and plant fungal pathogens. These lipopeptides act through membrane disruption and exhibit cytotoxicity in human cells. Their complex biosynthetic pathways promote chemical diversity, but their origins and mechanisms of structural diversification remain poorly understood. The production of these lipopeptides benefits the producer, either through their antifungal activity or other physiological functions, highlighting their potential biotechnological and therapeutic applications.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Plant Sciences
Kari Skjanes, Reidun Aesoy, Lars Herfindal, Hanne Skomedal
Summary: Microalgae have the potential to provide new peptides for cancer management through modulating immune responses, showing positive effects in various forms of cancer. However, further research is needed to fully understand and utilize this potential in cancer treatment.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Multidisciplinary Sciences
Rune Slimestad, Bendik Auran Rathe, Reidun Aesoy, Andrea Estefania Carpinteyro Diaz, Lars Herfindal, Torgils Fossen
Summary: Garden chervil is an important herb commonly used in Norwegian large-scale commercial kitchens. It is rich in phenolic compounds, with the main compound identified as 1,3-dicaffeoyl-5-malonyl-delta-quinide. Other known phenolic compounds were also found. These compounds exhibit moderate cytotoxicity against certain cells.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Haruna Muwonge, Hassan Kasujja, Nixon Niyonzima, Carolyne Atugonza, Josephine Kasolo, Allan Lugaajju, Joshua Nfambi, Sembajwe Larry Fred, Ali Moses Damani, Ivan Kimuli, Robert Zavuga, Faith Nakazzi, Edgar Kigozi, Damalie Nakanjako, David Patrick Kateete, Freddie Bwanga
Summary: This study reveals unique circulating miRNA profiles in the serum of patients with epidemic KS versus HIV-infected subjects with no KS, as well as in subjects with latent KS. Many of the dysregulated miRNAs in epidemic KS patients were previously reported to have crucial roles in KS infection and latency, highlighting their promising roles as potential biomarkers of latent or active KS infection.
NON-CODING RNA RESEARCH
(2022)
Article
Chemistry, Medicinal
Etienne Auvert, Reidun Aesoy, Francis Giraud, Lars Herfindal, Fabrice Anizon, Pascale Moreau
Summary: By selectively substituting the 1-position, we synthesized a series of new analogues and studied their effects on Pim-1 kinase inhibition and cytotoxicity against AML MOLM-13 cells.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Biology
Jan-Lukas Forde, Ingeborg Nerbo Reiten, Kari Espolin Fladmark, Astrid Olsnes Kittang, Lars Herfindal
Summary: This article presents a software tool for segmenting and tracking cancer cells from confocal images, enabling efficient processing of large datasets and obtaining more information about cancer cells.
Article
Biochemistry & Molecular Biology
Andrea Estefania Carpinteyro Diaz, Lars Herfindal, Heidi Lie Andersen, Torgils Fossen
Summary: This study investigates the natural products of Cryptogramma crispa for the first time, and identifies 15 compounds, including a new compound called 3-malonyl pteroside D. The study finds that these compounds exhibit selective cytotoxic activity against acute myeloid leukemia cells, but not against normal cells.
Article
Biochemistry & Molecular Biology
Sean P. Harrison, Richard Siller, Yoshiaki Tanaka, Maria Eugenia Chollet, Maria Eugenia de la Morena-barrio, Yangfei Xiang, Benjamin Patterson, Elisabeth Andersen, Carlos Bravo-Perez, Henning Kempf, Kathrine S. Asrud, Oleg Lunov, Alexandr Dejneka, Marie-Christine Mowinckel, Benedicte Stavik, Per Morten Sandset, Espen Melum, Saphira Baumgarten, Flavio Bonanini, Dorota Kurek, Santosh Mathapati, Runar Almaas, Kulbhushan Sharma, Steven R. Wilson, Froydis S. Skottvoll, Ida C. Boger, Inger Lise Bogen, Tuula A. Nyman, Jun Jie Wu, Ales Bezrouk, Dana Cizkova, Javier Corral, Jaroslav Mokry, Robert Zweigerdt, In-Hyun Park, Gareth J. Sullivan
Summary: The lack of physiological parity between 2D cell culture and in vivo culture has led to the development of more organotypic models, such as organoids. Organoids are characterized by a reliance on extracellular matrices (ECMs), 2D culture patterning, costly growth factors, and a lack of cellular diversity, structure, and organization. However, a new approach has been developed that overcomes these limitations and produces liver-like organoids with high cellular complexity and functionality. These organoids exhibit key liver functions and can be transplanted and maintained long-term. This approach has significant potential in various applications such as cellular therapy, tissue engineering, drug toxicity assessment, and disease modeling.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Elvar orn Viktorsson, Reidun Aesoy, Sindre Stoa, Viola Lekve, Stein Ove Doskeland, Lars Herfindal, Pal Rongved
Summary: This study focuses on optimizing lead compounds in phenazine 5,10-dioxides and highlights the importance of carbamate side chains as the optimal phenol-attached group. Derivatives without oxygen-based substituents in the 6th position of the phenazine skeleton retained potency when alkyl or carbamate side chains were attached to the phenol in position 1. Additionally, 7,8-dihalogenated and 7,8-dimethylated analogs of 1-hydroxyphenazine 5,10-dioxide showed increased cytotoxic potency in MOLM-13 cells compared to other compounds studied.
RSC MEDICINAL CHEMISTRY
(2021)