Requirements for comprehensive pharmacogenetic genotyping platforms

PGRNseq

(2016) Adam S. Gordon et al.   Pharmacogenetics and Genomics

Precision Medicine and Rare Genetic Variants

(2016) Volker M. Lauschke et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting

(2015) LV Kalman et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Long-Read Single Molecule Real-Time Full Gene Sequencing of Cytochrome P450-2D6

(2015) Wanqiong Qiao et al.   HUMAN MUTATION

Pharmacogenomics in the clinic

(2015) Mary V. Relling et al.   NATURE

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

(2015) Benjamin P. Kleinstiver et al.   NATURE

Genetic variation in the human cytochrome P450 supergene family

(2015) Kohei Fujikura et al.   Pharmacogenetics and Genomics

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

Design and Anticipated Outcomes of the eMERGE-PGx Project: A Multicenter Pilot for Preemptive Pharmacogenomics in Electronic Health Record Systems

(2014) L J Rasmussen-Torvik et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update

(2014) K R Crews et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Preemptive Genotyping for Personalized Medicine: Design of the Right Drug, Right Dose, Right Time—Using Genomic Data to Individualize Treatment Protocol

(2014) Suzette J. Bielinski et al.   MAYO CLINIC PROCEEDINGS

High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells

(2014) Yuexin Zhou et al.   NATURE

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Incidence, characteristics and risk factors of adverse drug reactions in hospitalized children – a prospective observational cohort study of 6,601 admissions

(2013) Signe Thiesen et al.   BMC Medicine

Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset

(2013) A. S. Gordon et al.   HUMAN MOLECULAR GENETICS

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

(2013) Hiroko Koike-Yusa et al.   NATURE BIOTECHNOLOGY

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy

(2012) R A Wilke et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Pharmacogenomics in clinical practice and drug development

(2012) Andrew R Harper et al.   NATURE BIOTECHNOLOGY

PharmGKB summary

(2012) Ellen M. McDonagh et al.   Pharmacogenetics and Genomics

Clinical and economic challenges facing pharmacogenomics

(2012) J Cohen et al.   PHARMACOGENOMICS JOURNAL

Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects

(2012) S C Sim et al.   PHARMACOGENOMICS JOURNAL

Adverse Drug Reactions Causing Admission to a Paediatric Hospital

(2012) Ruairi M. Gallagher et al.   PLoS One

Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

(2012) J. A. Tennessen et al.   SCIENCE

An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People

(2012) M. R. Nelson et al.   SCIENCE

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 Genotypes and Warfarin Dosing

(2011) J A Johnson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Personalizing medicine with clinical pharmacogenetics

(2011) Stuart A. Scott   GENETICS IN MEDICINE

Bring on the biomarkers

(2011) George Poste   NATURE

The dynamics of the brain transcriptome revealed

(2011) Monica Hoyos Flight   NATURE REVIEWS NEUROSCIENCE

Identification of CYP2C19*4B: pharmacogenetic implications for drug metabolism including clopidogrel responsiveness

(2011) S A Scott et al.   PHARMACOGENOMICS JOURNAL

The real cost of sequencing: higher than you think!

(2011) Andrea Sboner et al.   GENOME BIOLOGY

The functional spectrum of low-frequency coding variation

(2011) Gabor T Marth et al.   GENOME BIOLOGY

Characterization of 107 Genomic DNA Reference Materials for CYP2D6, CYP2C19, CYP2C9, VKORC1, and UGT1A1

(2010) Victoria M. Pratt et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants

(2010) Yingrui Li et al.   NATURE GENETICS

Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes

(2009) Emma C. Davies et al.   PLoS One