Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes

Animal models for diabetes: Understanding the pathogenesis and finding new treatments

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Nuclear Mechanisms of Insulin Resistance

(2016) Sona Kang et al.   TRENDS IN CELL BIOLOGY

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

De novolipogenesis in the liver in health and disease: more than just a shunting yard for glucose

(2015) Francis W. B. Sanders et al.   BIOLOGICAL REVIEWS

The application of engineered liver tissues for novel drug discovery

(2015) Christine Lin et al.   Expert Opinion on Drug Discovery

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens

(2015) Sandra March et al.   Nature Protocols

Hormone and Drug-Mediated Modulation of Glucose Metabolism in a Microscale Model of the Human Liver

(2015) Matthew D. Davidson et al.   TISSUE ENGINEERING PART C-METHODS

The interplay between hepatic stellate cells and hepatocytes in an in vitro model of NASH

(2015) Varenka J. Barbero-Becerra et al.   TOXICOLOGY IN VITRO

FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

(2015) InSug O-Sullivan et al.   Nature Communications

Mathematical modeling reveals modulation of both nuclear influx and efflux of Foxo1 by the IGF-I/PI3K/Akt pathway in skeletal muscle fibers

(2014) Robert J. Wimmer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man

(2014) Alexander Jais et al.   CELL

Hypoglycemia and Risk of Cardiovascular Disease and All-Cause Mortality in Insulin-Treated People With Type 1 and Type 2 Diabetes: A Cohort Study

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AMP-activated Protein Kinase α2 Protects against Liver Injury from Metastasized Tumors via Reduced Glucose Deprivation-induced Oxidative Stress

(2014) Shu-Lan Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

(2014) Hanlin Tao et al.   NATURE MEDICINE

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

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Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

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Hypoglycemia, Diabetes, and Cardiovascular Disease

(2012) Janet K. Snell-Bergeon et al.   Diabetes Technology & Therapeutics

Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function

(2011) Marcin Buler et al.   BIOCHEMICAL PHARMACOLOGY

Drug metabolism alterations in nonalcoholic fatty liver disease

(2011) Matthew D. Merrell et al.   DRUG METABOLISM REVIEWS

Management of type 2 diabetes: new and future developments in treatment

(2011) Abd A Tahrani et al.   LANCET

Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment

(2011) Briohny W. Smith et al.   Nature Reviews Endocrinology

Nonalcoholic fatty liver disease in type 2 diabetes mellitus

(2011) Kenneth Cusi   Current Opinion in Endocrinology Diabetes and Obesity

Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease

(2010) Christopher L. Gentile et al.   BIOFACTORS

Pregnane X Receptor and Constitutive Androstane Receptor at the Crossroads of Drug Metabolism and Energy Metabolism

(2010) J. Gao et al.   DRUG METABOLISM AND DISPOSITION

Animal models of nonalcoholic fatty liver disease

(2010) Lionel Hebbard et al.   Nature Reviews Gastroenterology & Hepatology

Kupffer cells in non-alcoholic fatty liver disease: The emerging view

(2009) György Baffy   JOURNAL OF HEPATOLOGY

Gene expression in human NAFLD

(2008) Dario Greco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism