Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer

Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease

(2016) Laura Vella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell-specific uptake of mantle cell lymphoma-derived exosomes by malignant and non-malignant B-lymphocytes

(2015) Inbal Hazan-Halevy et al.   CANCER LETTERS

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

Inhibition of Oncogenic Epidermal Growth Factor Receptor Kinase Triggers Release of Exosome-like Extracellular Vesicles and Impacts Their Phosphoprotein and DNA Content

(2015) Laura Montermini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Comprehensive Proteomics Analysis Reveals a Secretory Path- and Status-Dependent Signature of Exosomes Released from Tumor-Associated Macrophages

(2015) Yinghui Zhu et al.   JOURNAL OF PROTEOME RESEARCH

Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct

(2015) Rong Xu et al.   METHODS

Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines

(2015) J. P. Tosar et al.   NUCLEIC ACIDS RESEARCH

Global Profiling of Metabolic Adaptation to Hypoxic Stress in Human Glioblastoma Cells

(2015) Paulina Kucharzewska et al.   PLoS One

Differential fates of biomolecules delivered to target cells via extracellular vesicles

(2015) Masamitsu Kanada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells – Evidence of unique microRNA cargos

(2015) Taral R Lunavat et al.   RNA Biology

Extracellular vesicles in the biology of brain tumour stem cells – Implications for inter-cellular communication, therapy and biomarker development

(2015) Ichiro Nakano et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulated delivery of molecular cargo to invasive tumour-derived microvesicles

(2015) James W. Clancy et al.   Nature Communications

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

(2015) Valentina R. Minciacchi et al.   Oncotarget

17β-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells

(2015) Paul K. Wright et al.   Oncotarget

Cathepsin B Mediates the pH-Dependent Proinvasive Activity of Tumor-Shed Microvesicles

(2015) Ilaria Giusti et al.   NEOPLASIA

Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages

(2014) Giuseppina Turturici et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells

(2014) Tae Hoon Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells

(2014) YePing Dong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

EVpedia: a community web portal for extracellular vesicles research

(2014) D.-K. Kim et al.   BIOINFORMATICS

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

Cellular Disposal of miR23b by RAB27-Dependent Exosome Release Is Linked to Acquisition of Metastatic Properties

(2014) M. S. Ostenfeld et al.   CANCER RESEARCH

Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration

(2014) Liang Ma et al.   CELL RESEARCH

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Microvesicles mediate transfer of P-glycoprotein to paclitaxel-sensitive A2780 human ovarian cancer cells, conferring paclitaxel-resistance

(2014) Fang-fang Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Biology and proteomics of extracellular vesicles: harnessing their clinical potential

(2014) Crislyn D'Souza-Schorey et al.   Expert Review of Proteomics

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with MutatedKRASandp53DNA in the Serum Exosomes of Patients with Pancreatic Cancer

(2014) Christoph Kahlert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-200–containing extracellular vesicles promote breast cancer cell metastasis

(2014) Minh T.N. Le et al.   JOURNAL OF CLINICAL INVESTIGATION

Bladder Cancer Exosomes Contain EDIL-3/Del1 and Facilitate Cancer Progression

(2014) Carla J. Beckham et al.   JOURNAL OF UROLOGY

WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells

(2014) Elin J Ekström et al.   Molecular Cancer

Exosomal shuttling of miR-126 in endothelial cells modulates adhesive and migratory abilities of chronic myelogenous leukemia cells

(2014) Simona Taverna et al.   Molecular Cancer

Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells

(2014) Chiara Cossetti et al.   MOLECULAR CELL

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

(2014) Masayuki Shimoda et al.   NATURE CELL BIOLOGY

Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes

(2014) H Cui et al.   ONCOGENE

Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes

(2014) J P Webber et al.   ONCOGENE

Exosomes from Drug-Resistant Breast Cancer Cells Transmit Chemoresistance by a Horizontal Transfer of MicroRNAs

(2014) Wei-xian Chen et al.   PLoS One

Isolation, Characterization and Potential Role in Beta Cell-Endothelium Cross-Talk of Extracellular Vesicles Released from Human Pancreatic Islets

(2014) Federico Figliolini et al.   PLoS One

Quantitative and stoichiometric analysis of the microRNA content of exosomes

(2014) J. R. Chevillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different gDNA content in the subpopulations of prostate cancer extracellular vesicles: Apoptotic bodies, microvesicles, and exosomes

(2014) Elisa Lázaro-Ibáñez et al.   PROSTATE

New insights in the composition of extracellular vesicles from pancreatic cancer cells: implications for biomarkers and functions

(2014) Susanne Klein-Scory et al.   Proteome Science

The overexpression of a single oncogene (ERBB2/HER2) alters the proteomic landscape of extracellular vesicles

(2014) Maria Amorim et al.   PROTEOMICS

The clinical utility of microRNA-21 as novel biomarker for diagnosing human cancers

(2014) Lijun Shen et al.   TUMOR BIOLOGY

Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer

(2014) Kenji Takahashi et al.   FEBS Open Bio

Tetraspanins in Extracellular Vesicle Formation and Function

(2014) Zoraida Andreu et al.   Frontiers in Immunology

Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1

(2013) A. Bronisz et al.   CANCER RESEARCH

Large oncosomes mediate intercellular transfer of functional microRNA

(2013) Matteo Morello et al.   CELL CYCLE

Blebs produced by actin–myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs

(2013) G R Wickman et al.   CELL DEATH AND DIFFERENTIATION

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

The 786-0 renal cancer cell-derived exosomes promote angiogenesis by downregulating the expression of hepatocyte cell adhesion molecule

(2013) LONG ZHANG et al.   Molecular Medicine Reports

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF, and the neutralization of miR-150 attenuate tumor development

(2013) Yuchen Liu et al.   Protein & Cell

Microvesicle Cargo of Tumor-Associated MUC1 to Dendritic Cells Allows Cross-presentation and Specific Carbohydrate Processing

(2013) A. Rughetti et al.   Cancer Immunology Research

Trash or Treasure: extracellular microRNAs and cell-to-cell communication

(2013) Nobuyoshi Kosaka et al.   Frontiers in Genetics

Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease

(2012) Dolores Di Vizio et al.   AMERICAN JOURNAL OF PATHOLOGY

Microvesicles in Health and Disease

(2012) Jameel M. Inal et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Phosphatidylethanolamine is externalized at the surface of microparticles

(2012) Michael C. Larson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types

(2012) Jasenka Guduric-Fuchs et al.   BMC GENOMICS

Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay

(2012) T. Fiaschi et al.   CANCER RESEARCH

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

(2012) B Li et al.   ONCOGENE

Leukemia cell to endothelial cell communication via exosomal miRNAs

(2012) T Umezu et al.   ONCOGENE

Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells

(2012) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of the myofibroblast in tumor stroma remodeling

(2012) Marcela Otranto et al.   Cell Adhesion & Migration

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

(2012) Hina Kalra et al.   PLOS BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts

(2011) Jung Ah Cho et al.   GYNECOLOGIC ONCOLOGY

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1

(2011) M. J. Szczepanski et al.   HAEMATOLOGICA

Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice

(2011) Lilla Turiák et al.   Journal of Proteomics

Characterization of extracellular circulating microRNA

(2011) Andrey Turchinovich et al.   NUCLEIC ACIDS RESEARCH

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells

(2011) M. A. Antonyak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

(2011) Leonora Balaj et al.   Nature Communications

Alix is involved in caspase 9 activation during calcium-induced apoptosis

(2010) Flavie Strappazzon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

(2010) J. Webber et al.   CANCER RESEARCH

Reciprocal Activation of Prostate Cancer Cells and Cancer-Associated Fibroblasts Stimulates Epithelial-Mesenchymal Transition and Cancer Stemness

(2010) E. Giannoni et al.   CANCER RESEARCH

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomics Analysis of Bladder Cancer Exosomes

(2010) Joanne L. Welton et al.   MOLECULAR & CELLULAR PROTEOMICS

Tumor-derived microvesicles modulate the establishment of metastatic melanoma in a phosphatidylserine-dependent manner

(2009) Luize G. Lima et al.   CANCER LETTERS

Oncosome Formation in Prostate Cancer: Association with a Region of Frequent Chromosomal Deletion in Metastatic Disease

(2009) Dolores Di Vizio et al.   CANCER RESEARCH

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

Highlights of a new type of intercellular communication: microvesicle-based information transfer

(2009) E. Pap et al.   INFLAMMATION RESEARCH

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

(2009) E. U. Wieckowski et al.   JOURNAL OF IMMUNOLOGY

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

(2009) A. Zernecke et al.   Science Signaling

Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression

(2009) Masayuki Shimoda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Cell motility through plasma membrane blebbing

(2008) Oliver T. Fackler et al.   JOURNAL OF CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY