Can SARS-CoV-2 Infection Exacerbate Alzheimer’s Disease? An Overview of Shared Risk Factors and Pathogenetic Mechanisms

The chronic neuropsychiatric sequelae of COVID‐19: The need for a prospective study of viral impact on brain functioning

(2021) Gabriel A. Erausquin et al.   Alzheimers & Dementia

ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response

(2021) Cheng Wang et al.   Cell Stem Cell

Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

(2021) Yun Kit Yeoh et al.   GUT

SARS-COV2 Alters Blood Brain Barrier Integrity Contributing to Neuro-Inflammation

(2021) Jessica. L. Reynolds et al.   Journal of Neuroimmune Pharmacology

Pathophysiological Clues to How the Emergent SARS-CoV-2 Can Potentially Increase the Susceptibility to Neurodegeneration

(2021) Mahsa Dolatshahi et al.   MOLECULAR NEUROBIOLOGY

The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains

(2021) Rongrong Chen et al.   Frontiers in Neurology

Age-dependent effects of the recombinant spike protein/SARS-CoV-2 on the M–CSF– and IL-34-differentiated macrophages in vitro

(2021) Carolina Duarte et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serum ferritin levels in inflammation: a retrospective comparative analysis between COVID-19 and emergency surgical non-COVID-19 patients

(2021) Filippo Banchini et al.   World Journal of Emergency Surgery

SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration

(2021) Danish Idrees et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neurologic aspects of coronavirus disease of 2019 infection

(2021) Catherine E. Hassett et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Dysregulation of brain and choroid plexus cell types in severe COVID-19

(2021) Andrew C. Yang et al.   NATURE

The impact of the COVID-19 pandemic on dementia risk: Potential pathways to cognitive decline

(2021) Jeffrey D Pyne et al.   Neurodegenerative Diseases

Microbiota-Gut-Brain Communication in the SARS-CoV-2 Infection

(2021) Luana M. Manosso et al.   Cells

Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization

(2021) Yongjian Wu et al.   npj Biofilms and Microbiomes

A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene

(2021) Naciye Magusali et al.   BRAIN

Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

(2021) Shu Liu et al.   Nature Communications

ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease

(2020) Charles E. Evans et al.   ACTA NEUROPATHOLOGICA

The neuroinvasive potential of SARS‐CoV2 may be at least partially responsible for the respiratory failure of COVID‐19 patients

(2020) Yan‐Chao Li et al.   JOURNAL OF MEDICAL VIROLOGY

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Role of brain renin angiotensin system in neurodegeneration: An update

(2020) Oyesiji A. Abiodun et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Host Calcium Channels and Pumps in Viral Infections

(2020) Xingjuan Chen et al.   Cells

Anticipating and Mitigating the Impact of the COVID-19 Pandemic on Alzheimer's Disease and Related Dementias

(2020) Eric E. Brown et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients

(2020) Xiaohua Chen et al.   CLINICAL INFECTIOUS DISEASES

Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization

(2020) Tao Zuo et al.   GASTROENTEROLOGY

A first case of meningitis/encephalitis associated with SARS-Coronavirus-2

(2020) Takeshi Moriguchi et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy

(2020) Graziano Onder et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus ‐2 (SARS‐CoV‐2)

(2020) Alberto Paniz‐Mondolfi et al.   JOURNAL OF MEDICAL VIROLOGY

APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort

(2020) Chia-Ling Kuo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China

(2020) Joseph T. Wu et al.   NATURE MEDICINE

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

(2020) Ling Mao et al.   JAMA Neurology

The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer’s Disease

(2020) Courtney M. Kloske et al.   Frontiers in Immunology

A Systematic Review of COVID-19 Epidemiology Based on Current Evidence

(2020) Minah Park et al.   Journal of Clinical Medicine

Does SARS-CoV-2 infection cause chronic neurological complications?

(2020) Erin R. Hascup et al.   GeroScience

ACE2 activator diminazene aceturate ameliorates Alzheimer's disease-like neuropathology and rescues cognitive impairment in SAMP8 mice

(2020) Rui Duan et al.   Aging-US

Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis

(2020) Keshav K. Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Report on Electroencephalographic Findings in Critically Ill Patients with COVID ‐19

(2020) Hervé Vespignani et al.   ANNALS OF NEUROLOGY

Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19

(2020) Shelli Farhadian et al.   BMC Neurology

SARS-CoV-2 infects human neural progenitor cells and brain organoids

(2020) Bao-Zhong Zhang et al.   CELL RESEARCH

Alterations of the Gut Microbiota in Patients With Coronavirus Disease 2019 or H1N1 Influenza

(2020) Silan Gu et al.   CLINICAL INFECTIOUS DISEASES

Potential Novel Role of COVID-19 in Alzheimer’s Disease and Preventative Mitigation Strategies

(2020) Sean X. Naughton et al.   JOURNAL OF ALZHEIMERS DISEASE

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort

(2020) Janice L Atkins et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Neurological associations of COVID-19

(2020) Mark A Ellul et al.   LANCET NEUROLOGY

Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19

(2020) Nelly Kanberg et al.   NEUROLOGY

Early postmortem brain MRI findings in COVID-19 non-survivors

(2020) Tim Coolen et al.   NEUROLOGY

The COVID-19 Pandemic: Consideration for Brain Infection

(2020) Xiao-Yuan Mao et al.   NEUROSCIENCE

Neuropathological Features of Covid-19

(2020) Isaac H. Solomon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19

(2020) Raphaël Cauchois et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrospective Observational Study of Brain Magnetic Resonance Imaging Findings in Patients with Acute SARS-CoV-2 Infection and Neurological Manifestations

(2020) Lydia Chougar et al.   RADIOLOGY

Immediate and long-term consequences of COVID-19 infections for the development of neurological disease

(2020) Michael T. Heneka et al.   Alzheimers Research & Therapy

RNA-GPS Predicts SARS-CoV-2 RNA Residency to Host Mitochondria and Nucleolus

(2020) Kevin E. Wu et al.   Cell Systems

Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease

(2020) Charlotte Mezö et al.   Acta Neuropathologica Communications

Molecular and Imaging Biomarkers in Alzheimer’s Disease: A Focus on Recent Insights

(2020) Chiara Villa et al.   Journal of Personalized Medicine

SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression

(2020) Rubens Cecchini et al.   MEDICAL HYPOTHESES

Mitochondria and microbiota dysfunction in COVID-19 pathogenesis

(2020) Jumana Saleh et al.   MITOCHONDRION

Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms

(2020) Soheil Mohammadi et al.   MOLECULAR NEUROBIOLOGY

Neurobiochemical Cross-talk Between COVID-19 and Alzheimer’s Disease

(2020) Mohammad Azizur Rahman et al.   MOLECULAR NEUROBIOLOGY

Pathological changes in the lungs and lymphatic organs of twelve COVID-19 autopsy cases

(2020) Qian Liu et al.   National Science Review

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression

(2020) Jesús Beltrán-García et al.   Antioxidants

Aging in COVID-19: Vulnerability, immunity and intervention

(2020) Yiyin Chen et al.   AGEING RESEARCH REVIEWS

Neuroprotective immunity by essential nutrient “Choline” for the prevention of SARS CoV2 infections: An in silico study by molecular dynamics approach

(2020) Papia Chowdhury et al.   CHEMICAL PHYSICS LETTERS

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Cognitive impact of COVID-19: looking beyond the short term

(2020) Scott Miners et al.   Alzheimers Research & Therapy

Possible immunity, inflammation, and oxidative stress mechanisms of Alzheimer’s disease in COVID-19 patients

(2020) Haili Wang et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Systemic translocation of Staphylococcus drives autoantibody production in HIV disease

(2019) Zhenwu Luo et al.   Microbiome

The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease

(2019) Celia G. Fernandez et al.   Frontiers in Aging Neuroscience

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

(2019) Kam-Leung Siu et al.   FASEB JOURNAL

Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway

(2019) John P. Haran et al.   mBio

Systemic inflammation impairs microglial Aβ clearance through NLRP 3 inflammasome

(2019) Dario Tejera et al.   EMBO JOURNAL

Theories of Aging and the Prevalence of Alzheimer’s Disease

(2019) Kaynara Trevisan et al.   Biomed Research International

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

(2019) Yang Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement

(2019) Gabriela Dumitrita Stanciu et al.   Biomolecules

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

(2018) Xian Xia et al.   AGING CELL

Angiotensin 1-7 ameliorates 6-hydroxydopamine lesions in hemiparkinsonian rats through activation of MAS receptor/PI3K/Akt/BDNF pathway and inhibition of angiotensin II type-1 receptor/NF-κB axis

(2018) Mostafa A. Rabie et al.   BIOCHEMICAL PHARMACOLOGY

Medical Comorbidity in Alzheimer’s Disease: A Nested Case-Control Study

(2018) Jen-Hung Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

(2018) Zhen-Qian Zhuang et al.   JOURNAL OF ALZHEIMERS DISEASE

Stimulation of ACE2/ANG(1–7)/Mas Axis by Diminazene Ameliorates Alzheimer’s Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway

(2018) Ahmed S. Kamel et al.   MOLECULAR NEUROBIOLOGY

IL-6 deficiency alters spatial memory in 4- and 24-month-old mice

(2018) Izabela Bialuk et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Probiotic Supplementation in Patients with Alzheimer’s Dementia – An Explorative Intervention Study

(2018) Friedrich Leblhuber et al.   Current Alzheimer Research

Nuclear receptor ERRα and transcription factor ERG form a reciprocal loop in the regulation of TMPRSS2:ERG fusion gene in prostate cancer

(2018) Zhenyu Xu et al.   ONCOGENE

Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection

(2018) Wanli Xu et al.   Scientific Reports

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Cholinergic modulation of the immune system presents new approaches for treating inflammation

(2017) Donald B. Hoover   PHARMACOLOGY & THERAPEUTICS

Serum tumour necrosis factor-α and interleukin-6 levels in Alzheimer's disease and mild cognitive impairment

(2017) Yo Sup Kim et al.   Psychogeriatrics

Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients

(2017) María J. Villanueva-Millán et al.   Journal of the International AIDS Society

Serum tumour necrosis factor-α and interleukin-6 levels in Alzheimer's disease and mild cognitive impairment

(2017) Yo Sup Kim et al.   Psychogeriatrics

Plasma Angiotensin-(1-7) is a Potential Biomarker for Alzheimer's Disease

(2016) Teng Jiang et al.   CURRENT NEUROVASCULAR RESEARCH

Age, APOE and sex: Triad of risk of Alzheimer’s disease

(2016) Brandalyn C. Riedel et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology

(2016) Patrick Gavin Kehoe et al.   Alzheimers Research & Therapy

The Implications of Angiotensin-Converting Enzymes and Their Modulators in Neurodegenerative Disorders: Current and Future Perspectives

(2015) Parneet Kaur et al.   ACS Chemical Neuroscience

Neuronal Regulation of Neuroprotective Microglial Apolipoprotein E Secretion in Rat In Vitro Models of Brain Pathophysiology

(2015) Elisabetta Polazzi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer’s Disease

(2015) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

(2015) Scott Ayton et al.   Nature Communications

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intestinal Microbiota, Microbial Translocation, and Systemic Inflammation in Chronic HIV Infection

(2014) Duy M. Dinh et al.   JOURNAL OF INFECTIOUS DISEASES

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

ApoE isoform-dependent changes in hippocampal synaptic function

(2009) Kimberly M Korwek et al.   Molecular Neurodegeneration

Inflammation, microglia, and alzheimer's disease

(2009) Brent Cameron et al.   NEUROBIOLOGY OF DISEASE

Brain renin angiotensin in disease

(2008) M. Ian Phillips et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cholinergic Neuronal and Axonal Abnormalities Are Present Early in Aging and in Alzheimer Disease

(2008) Changiz Geula et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

(2008) Lars Bertram et al.   NATURE REVIEWS NEUROSCIENCE

Linking Calcium to Aβ and Alzheimer's Disease

(2008) Kim N. Green et al.   NEURON

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES