Article
Pharmacology & Pharmacy
Hichem Bouchenaki, Amandine Bernard, Flavien Bessaguet, Simon Frachet, Laurence Richard, Franck Sturtz, Laurent Magy, Sylvie Bourthoumieu, Claire Demiot, Aurore Danigo
Summary: Ramipril has the potential to prevent paclitaxel-induced peripheral neuropathy, and the neuroprotective role of ramipril in this condition is mediated through the involvement of the AT2 receptor.
Review
Neurosciences
Judy Ghalayini, Gabrielle L. Boulianne
Summary: Recent studies have shown that certain antihypertensive drugs like ACE inhibitors and ARBs can reduce the incidence and progression of Alzheimer's disease. However, the reason why these drugs are effective in some patients and not others, independent of their blood pressure regulation role, remains unclear. Understanding the mechanisms behind this is essential for developing effective AD therapeutics.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Malik Nassan, Iyas Daghlas, Ignazio S. Piras, Emily Rogalski, Lianne M. Reus, Yolande Pijnenburg, Leah K. Cuddy, Richa Saxena, M-Marsel Mesulam, Matt Huentelman
Summary: This study used genetic approaches to find that angiotensin-converting enzyme (ACE) inhibition is associated with Alzheimer's disease and frontotemporal dementia, but not with Lewy body dementia or vascular dementia. These results provide evidence for further research on the neurocognitive effects of ACE inhibition.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Robert MacLachlan, Patrick Gavin Kehoe, J. Scott Miners
Summary: The activity of angiotensin-converting enzyme-1 (ACE-1) is induced in the early stages of Alzheimer's disease (AD), independently from the normal physiological changes in ACE-1 protein during aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Cell Biology
Filipa Gouveia, Antoni Camins, Miren Ettcheto, Joana Bicker, Amilcar Falcao, M. Teresa Cruz, Ana Fortuna
Summary: Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by Tau hyperphosphorylation and A beta deposits. Recent scientific evidence suggests that age-related vascular alterations and cardiovascular risk factors play a role in the development of AD. Drugs targeting the Renin Angiotensin System (RAS) have the potential to delay AD development due to their effects on brain RAS. The ACE 1/Ang II/AT1R axis in AD is believed to have detrimental effects, while the alternative axis ACE 1/Ang II/AT2R; ACE 2/Ang (1 7)/MasR; Ang IV/AT4R (IRAP) seems to have beneficial effects on memory and cognition. Retrospective studies and pre-clinical studies support the therapeutic potential of RAS drugs for AD.
AGEING RESEARCH REVIEWS
(2022)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ming-Hui Yang, Tzu-Chuan Ho, Chin-Chuan Chang, Yuh-Shan Su, Cheng-Hui Yuan, Kuo-Pin Chuang, Yu-Chang Tyan
Summary: Two types of ACE inhibitors, lisinopril and benazepril HCl, were found to upregulate LRP1B and 14-3-3 protein ζ/δ in neuroblastoma cells. Benazepril HCl also increased the expression of calreticulin. These findings suggest that ACE inhibitors may have potential in treating Alzheimer's disease by promoting neuronal cell survival independently of their antihypertensive effect.
Article
Multidisciplinary Sciences
Jakub Jankowski, Hye Kyung Lee, Julia Wilflingseder, Lothar Hennighausen
Summary: This study reports on the genetic programs activated in kidney cells in response to interferons during COVID-19, and the inhibitory effect of a Janus kinase inhibitor. The findings help identify kidney-specific interferon responses.
Article
Cell Biology
Chun Xu, Debra Garcia, Yongke Lu, Kaysie Ozuna, Donald A. Adjeroh, Kesheng Wang
Summary: This study examines the associations of angiotensin-converting enzyme-1 (ACE1) and apolipoproteins (APOs) with Alzheimer's disease (AD), cardiovascular diseases (CVDs), and endocrine-metabolic diseases (EMDs). The study finds that certain APO proteins and ACE1 levels are associated with AD, MCI, CVD, and EMD.
Review
Pharmacology & Pharmacy
Saeed Alshahrani
Summary: Chronic kidney disease is a complex condition with various underlying causes. Current pharmacotherapeutic treatment options aim to slow disease progression and improve quality of life but cannot achieve complete cure. The first-line treatment for controlling blood pressure in chronic kidney disease is the use of renin-angiotensin-aldosterone system modulators. These modulators, including direct renin inhibitors, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers, have different structures and mechanisms of action, leading to varying treatment outcomes. The choice of modulator depends on patient presentation, comorbidities, treatment availability and affordability, and healthcare provider expertise. Comparative studies between these modulators are currently lacking, which could provide valuable information for healthcare providers and researchers. This review compares the direct renin inhibitor (aliskiren) with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, aiming to identify specific areas of interest for intervention and the best possible treatment option.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biology
Wataru Nemoto, Ryota Yamagata, Osamu Nakagawasai, Koichi Tan-No
Summary: Evidence suggests that Ang-related peptides play a role in pain regulation. Understanding the mechanisms of pain regulation by Ang-related peptides in various tissues and organs can aid in the development of targeted drug therapies. This review focuses on the current evidence regarding pain regulation by Ang-related peptides in the central and peripheral regions involved in pain transmission.
Article
Plant Sciences
Carla Georgia Rodrigues Guimaraes Souto, Bethania Rosa Lorencone, Aline Aparecida Macedo Marques, Rhanany Alan Calloi Palozi, Paulo Vitor Moreira Romao, Lucas Pires Guarnier, Cleide Adriane Signor Tirloni, Ariany Carvalho dos Santos, Roosevelt Isaias Carvalho Souza, Priscila Megda Joao Job Zago, Francislaine Aparecida dos Reis Livero, Emerson Luiz Botelho Lourenco, Denise Brentan Silva, Arquimedes Gasparotto Junior
Summary: The ethanolic extract of Talinum paniculatum showed significant cardiorenal protective effects in rats, normalizing electrocardiographic and hemodynamic alterations, and preventing ventricle remodeling. These effects were associated with serum antioxidant activity and angiotensin-converting enzyme (ACE) inhibition, indicating potential benefits for hypertensive patients with doxorubicin-induced cardiotoxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Xiao-Ce Dai, Zhuo-Yu An, Zi-Yang Wang, Zi-Zhen Wang, Yi-Ren Wang
Summary: The use of ACEIs/ARBs does not appear to have a significant impact on mortality, disease severity, or duration of hospitalization in COVID-19 patients. Based on the findings of this meta-analysis, there is no support for discontinuing treatment with ACEIs or ARBs in patients with COVID-19.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Shuwei Wang, Qi Han, Zhaolan Wei, Yunyi Wang, Lingfu Deng, Mingqing Chen
Summary: The study found that exposure to formaldehyde can cause an increase in blood pressure and damage to the heart, aortic vessels, and kidneys. By blocking the ACE/AT1R axis using an ACE inhibitor, the increase in blood pressure and pathological changes caused by formaldehyde exposure can be alleviated. This result improves our understanding of the impact of formaldehyde exposure on the development of hypertension.
Article
Critical Care Medicine
Tim Lahm, Edward Hess, Anna E. Baron, Thomas M. Maddox, Mary E. Plomondon, Gaurav Choudhary, Bradley A. Maron, Roham T. Zamanian, Peter J. Leary
Summary: ACEIs and ARBs are associated with lower mortality in patients with pulmonary hypertension, while AA use is a marker of disease severity and may be used preferentially in sicker patients. ACEIs and ARBs may represent a novel treatment strategy for different PH phenotypes.
Article
Pharmacology & Pharmacy
Neha Sharma, Navneet Khurana, Arunachalam Muthuraman, Puneet Utreja
Summary: In this study, it was found that vanillic acid has anti-Parkinson's effects in rats induced with rotenone, reducing muscle rigidity and motor defects while lowering oxidative stress levels and providing neuroprotection for neurons.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
M. Ramesh, Arunachalam Muthuraman
Summary: Neuropathic pain is caused by physical damage, injury, or dysfunction of neuronal fibers and its pathophysiology is complex. Computer-aided drug discovery approaches have significantly contributed to discovering new hits/ligands for treating neuropathic pain, assisting researchers in finding potential drugs/drug-like molecules for management.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Khian Giap Lim, Rajavel Varatharajan, Arunachalam Muthuraman
Summary: This study investigated the beneficial effects of beta-carotene on diabetes-associated vascular dementia and its antioxidative actions. Beta-carotene treatment improved cognitive function and reduced oxidative stress markers in rats with diabetic vascular dementia.
Article
Biochemistry & Molecular Biology
Jagadeesh Dhamodharan, Ganthimathy Sekhar, Arunachalam Muthuraman
Summary: This study aimed to explore the ameliorative potential of gefitinib (GE) in Alzheimer's disease (AD) mice. The results showed that GE significantly improved AD-associated behavioral, biochemical, and histopathological changes by inhibiting EGFR kinase activation and having antioxidant and antilipid peroxidative effects against A beta(1-42) oligomer-induced neurotoxicity.
Article
Engineering, Chemical
Aswinprakash Subramanian, Jayaraman Thirunavukkarasu, Arunachalam Muthuraman
Summary: Diabetic retinopathy is a common complication of diabetes, and current drug treatments are limited. Astaxanthin has the potential to be used as a natural medicine for managing diabetic retinopathy due to its antioxidant, anti-diabetic, and neuron-specific enolase inhibitory properties.
Article
Engineering, Chemical
Khian Giap Lim, Arunachalam Muthuraman
Summary: This study evaluated the ameliorative effect of beta-carotene in a rat model of diabetic vascular dementia. The results showed that beta-carotene improved cognitive function and normalized neurotransmitter changes, suggesting its potential as a therapeutic agent for the management of vascular dementia.
Article
Biochemistry & Molecular Biology
Sohrab A. Shaikh, Rajavel Varatharajan, Arunachalam Muthuraman
Summary: This study evaluated the effectiveness of TRF in T2DM-induced VaD rats, showing that TRF significantly attenuated biochemical parameters and prevented memory loss, indicating potential neuroprotective action.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Nallupillai Paramakrishnan, Laxmikant Chavan, Khian Giap Lim, Yamunna Paramaswaran, Arunachalam Muthuraman
Summary: This study aimed to evaluate the effect of palm oil mill effluent-derived beta carotene (PBC) on diabetic neuropathic pain (DNP) in zebrafish. The results showed that PBC improved the behavioral and biochemical changes associated with DNP, exhibiting potential antioxidant, anti-lipid peroxidation, and MMP-13 inhibitory actions.
Article
Biochemistry & Molecular Biology
Arunachalam Muthuraman, Muthusamy Ramesh, Fazlina Mustaffa, Ahmed Nadeem, Shamama Nishat, Nallupillai Paramakrishnan, Khian Giap Lim
Summary: Molecular docking is used to assess the therapeutic potential of pharmaceutical agents. This study characterized the binding properties of beta-carotene (BC) to acetylcholine esterase (AChE) proteins using molecular docking. The mechanism of AChE inhibition was assessed through in vitro kinetic study, and the role of BC was tested using the zebrafish embryo toxicity test (ZFET). The results showed significant ligand binding mode between BC and AChE, and BC exhibited mild toxicity at higher doses in ZFET with biomarker changes.
Article
Chemistry, Medicinal
Yamunna Paramaswaran, Aswinprakash Subramanian, Nallupillai Paramakrishnan, Muthusamy Ramesh, Arunachalam Muthuraman
Summary: Diabetic retinopathy (DR) is a retinal degeneration caused by microvascular dysfunction. This study investigates the use of beta-carotene (PBC) from palm oil mill effluent in the treatment of diabetes in mice. The results show that PBC and dexamethasone administration can ameliorate the diabetes-induced retinal alterations.
Article
Chemistry, Medicinal
Sohrab A. Shaikh, Arunachalam Muthuraman
Summary: Neurovascular dysfunction can lead to vascular dementia (VaD), the second most common type of dementia. Toxic metals like aluminium can increase the risk of VaD associated with neurovascular dysfunction. The study investigated whether a natural antioxidant derived from palm oil called tocotrienol-rich fraction (TRF) could alleviate aluminium chloride-induced VaD in rats. Results showed that TRF treatment improved memory, reduced brain oxidative stress, improved endothelial function, facilitated neovascularisation process, protected neurons, and improved memory in VaD rats.
Article
Chemistry, Medicinal
Nallupillai Paramakrishnan, Khian Giap Lim, Yamunna Paramaswaran, Nemat Ali, Mohammad Waseem, Gamal A. Shazly, Yousef A. Bin Jardan, Arunachalam Muthuraman
Summary: This study investigates the impact of AST on cerebrovascular disease-associated AD through the inhibition of MMP-13. The results show that AST can ameliorate behavioral and biochemical changes, making it a potential therapeutic approach for the management of AD.
Article
Biochemistry & Molecular Biology
Arunachalam Muthuraman, Abu Sadat Md Sayem, Sakthiganapathi Meenakshisundaram, Nemat Ali, Sheikh F. Ahmad, Abdullah F. Alasmari, Shamama Nishat, Khian Giap Lim, Yamunna Paramaswaran
Summary: The present study investigates the role of beta-carotene in attenuating IS-induced renal dysfunction through regulation of mitochondrial redox balance by BCO2 actions. The findings suggest that BC can alleviate renal damage caused by IS by modulating mitochondrial function.
Meeting Abstract
Anatomy & Morphology
Jagadeesh Dhamodharan, Arunachalam Muthuraman, Ganthimathy Sekhar
JOURNAL OF ANATOMY
(2022)
Article
Pharmacology & Pharmacy
Xiaolan Yang, Yang Gao, Aswin Prakash Subramanian, Arunachalam Muthuraman, Chao Huang
Summary: The study demonstrated that NCQ has a therapeutic effect on diabetic retinopathy (DR), attenuating the effects induced by STZ and regulating multiple biochemical abnormalities, comparable to dexamethasone treatment.
LATIN AMERICAN JOURNAL OF PHARMACY
(2021)