Article
Clinical Neurology
Klodian Dhana, Todd Beck, Pankaja Desai, Robert S. Wilson, Denis A. Evans, Kumar B. Rajan
Summary: This study estimates the prevalence and number of people living with Alzheimer's disease (AD) dementia in the US. The results show higher prevalence in the east and southeastern regions, with Maryland, New York, and Mississippi having the highest rates. California, Florida, and Texas have the highest number of AD patients. The state- and county-specific estimates can help develop region-specific strategies for care.
ALZHEIMERS & DEMENTIA
(2023)
Review
Biochemistry & Molecular Biology
Vaclav Trojan, Leos Landa, Alexandra Sulcova, Jiri Sliva, Radovan Hrib
Summary: The use of cannabinoids, particularly THC and CBD, for therapeutic purposes has gained attention. THC has limitations due to its psychotropic effects and potential for dependence. CBD, on the other hand, is highlighted for its therapeutic properties without the risk of dependence.
Article
Cell Biology
Hemant Srivastava, Alexander Tate Lasher, Akash Nagarajan, Liou Y. Sun
Summary: Alzheimer's disease (AD) is a prevalent form of dementia that is characterized by cognitive decline with age. Treatment options for AD are limited, making it a significant public health concern. Recent research has shown that metabolic dysfunction and insulin therapy may play a role in the development of AD. In this study, the TgF344-AD rat model was used to examine the relationship between body composition, insulin sensitivity, glucose tolerance, and behavioral assessments of learning, memory, and anxiety. The results showed that female TgF344-AD rats exhibited impaired glucose clearance and reduced insulin sensitivity, while male rats showed no differences or improved glucose clearance. Male rats also displayed impairments in learning and memory, while female rats showed impairments only at a later age. Additionally, female rats displayed increased anxiety at a younger age, but no differences were detected in males. These findings suggest that metabolic impairments occur before or simultaneously with cognitive decline and anxiety, in a sexually dimorphic manner, in the TgF344-AD rat model.
Review
Biochemistry & Molecular Biology
Jana Tchekalarova, Rumiana Tzoneva
Summary: Aging and neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are linked by common features like mitochondrial dysfunction and protein aggregation. The rising costs of caring for elderly patients with these diseases is a major issue in today's demographic crisis. Oxidative stress and imbalanced antioxidant defense system play crucial roles in age-related neurodegeneration, and diminished melatonin release with aging further increases susceptibility to these diseases. Understanding the underlying mechanisms and melatonin's role is important for developing precise treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sandrine Joly, Lea Rodriguez, Vincent Pernet
Summary: The study found that in aging mice, the amyloidogenic and nonamyloidogenic pathways are not involved in visual function decline, and retinal neurons do not have the capacity to secrete A beta like other cortical and hippocampal neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Huiyi Wu, Lei Huang, Shushan Zhang, Yang Zhang, Yajia Lan
Summary: The study aimed to evaluate the associations between daytime napping, biological aging measures, and cognition, and examine whether the effects on cognition were mediated by a more advanced state of aging. It was found that non-nappers showed a more advanced state of aging and faster cognitive decline compared to moderate nappers. The results suggest that moderate napping could promote healthy aging and reduce cognitive decline in middle-aged and older Chinese adults.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Cell Biology
Alexander M. Kulminski, Ethan Jain-Washburn, Elena Loiko, Yury Loika, Fan Feng, Irina Culminskaya, Alzheimer's Disease Neuroimaging Initiative Alzheimers Dis Neuroimaging Initiative
Summary: This study examined the associations of APOE alleles and polygenic profiles with cerebrospinal fluid and plasma biomarkers, revealing differential effects of specific alleles on different biomarkers.
Article
Neurosciences
Joseph R. Winer, Allison Morehouse, Laura Fenton, Theresa M. Harrison, Lylian Ayangma, Mark Reed, Samika Kumar, Suzanne L. Baker, William J. Jagust, Matthew P. Walker
Summary: This study found that early-stage tau and Aβ deposition in Alzheimer's disease can impact sleep, with tau burden leading to worse objective sleep and Aβ burden associated with decreased self-reported sleep quality. Aβ deposition also predicts a mismatch between objective and subjective sleep evaluation, with individuals underestimating their sleep, which is further linked to worse executive function.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Aladdin H. Shadyab, Linda K. McEvoy, Steve Horvath, Eric A. Whitsel, Stephen R. Rapp, Mark A. Espeland, Susan M. Resnick, JoAnn E. Manson, Jiu-Chiuan Chen, Brian H. Chen, Wenjun Li, Kathleen M. Hayden, Wei Bao, Cynthia D. J. Kusters, Andrea Z. LaCroix
Summary: The study examined the association between epigenetic age acceleration and cognitive impairment, finding that intrinsic AgeAccel was not significantly associated with cognitive impairment overall, but was associated with impairment among women who developed coronary heart disease.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Jorge J. Llibre-Guerra, Yan Li, Isabel Elaine Allen, Juan C. Llibre-Guerra, Ana M. Rodriguez Salgado, Ana Ibis Penalver, Arianna Almirall Sanchez, Jennifer S. Yokoyama, Lea Grinberg, Victor Valcour, Bruce L. Miller, Juan J. Llibre-Rodriguez
Summary: This study examines the effects of self-identified race and genetic admixture on dementia prevalence and cognitive performance. The results show no independent association between self-identified race and African ancestry proportion with dementia prevalence and cognitive performance. This suggests that observed differences in dementia prevalence among diverse populations may be primarily influenced by social determinants of health.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Yi-Hui Kao, Chih-Cheng Hsu, Yuan-Han Yang
Summary: The prevalence of dementia in long-term care institutions can be as high as 87.1%. Risk factors for dementia include advanced age, low education, hypertension, Parkinsonism, respiratory disease, stroke, and intractable epilepsy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Rachel Pei-Hsuan Wang, Jianpan Huang, Kannie Wai Yan Chan, Wai Keung Leung, Tetsuya Goto, Yuen-Shan Ho, Raymond Chuen-Chung Chang
Summary: This study demonstrates that systemic inflammation caused by periodontitis contributes to the development of Alzheimer's disease and leads to cognitive decline.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Meng Zhang, Andrea B. Ganz, Susan Rohde, Annemieke J. M. Rozemuller, Netherlands Brain Bank, Marcel J. T. Reinders, Philip Scheltens, Marc Hulsman, Jeroen J. M. Hoozemans, Henne Holstege
Summary: In this study, the brains of centenarians were examined to determine whether they exhibited resistance or resilience to Alzheimer's disease-related neuropathological substrates. The results showed that some centenarians maintained cognitive health despite the presence of high levels of AD-related neuropathology.
ALZHEIMERS & DEMENTIA
(2023)
Review
Biochemistry & Molecular Biology
Vladimir Sukhorukov, Dmitry Voronkov, Tatiana Baranich, Natalia Mudzhiri, Alina Magnaeva, Sergey Illarioshkin
Summary: Aging is associated with cognitive decline due to accumulated damage to brain cells, with mitophagy playing a crucial role in managing mitochondrial quality and quantity. Mitophagy defects contribute to aging and age-related diseases, highlighting potential therapeutic targets for neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ekin Bolukbasi, Nathaniel S. Woodling, Dobril K. Ivanov, Jennifer Adcott, Andrea Foley, Arjunan Rajasingam, Lauren M. Gittings, Benjamin Aleyakpo, Teresa Niccoli, Janet M. Thornton, Linda Partridge
Summary: Reduced activity of the insulin/insulin-like growth factor signaling pathway has been shown to increase healthy lifespan in various animal species. In the adult nervous system of Drosophila, specific transcription factors like neuronal FKH and glial FOXO play independent roles in extending healthy lifespan. The importance of cell type-specific mapping of transcription factor activity for preserving healthy function with age is highlighted in this study.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Integrative & Complementary Medicine
Giovanna Felipe Cavalcante e Costa, Hisao Nishijo, Leonardo Ferreira Caixeta, Tales Alexandre Aversi-Ferreira
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2018)
Article
Anatomy & Morphology
Tales Alexandre Aversi-Ferreira, Roqueline A. G. M. F. Aversi-Ferreira, Guilherme Nobre Lima do Nascimento, Enkhjargal Nyamdavaa, Mariana Ferreira Araujo, Peandra Paula Ribeiro, Nattany Camila da Silva, Lorraine Dias Brandao, Lucia Helena Almeida Gratao, Taina de Abreu, Gabriel de Abreu Pfrimer, Vanessa Vieira de Souza, Nayane Peixoto Soares, Etsuro Hori, Hisao Nishijo
INTERNATIONAL JOURNAL OF MORPHOLOGY
(2012)
Article
Veterinary Sciences
Taina de Abreu, Gabriel A. Pfrimer, Roqueline A. G. M. F. Aversi-Ferreira, Lorraine D. Brandao, Rafael S. Maior, Hisao Nishijo, Tales A. Aversi-Ferreira
PESQUISA VETERINARIA BRASILEIRA
(2012)
Article
Biotechnology & Applied Microbiology
Roqueline A. G. M. F. Aversi-Ferreira, Taina de Abreu, Gabriel A. Pfrimer, Sylla F. Silva, Janine M. Ziermann, Frederico O. Carneiro-e-Silva, Carlos Tomaz, Maria Clotilde H. Tavares, Rafael S. Maior, Tales A. Aversi-Ferreira
BIOMED RESEARCH INTERNATIONAL
(2013)
Article
Biotechnology & Applied Microbiology
Tales Alexandre Aversi-Ferreira, Emmanuel Freitas-Ferreira, Roqueline A. G. M. F. Aversi-Ferreira, Karolyne Cordeiro-de-Oliveira, Gezianne Lopes-de-Freitas, Kaynara Trevisan, Giovanna Felipe Cavalcante, Ediana Vasconcelos-da-Silva, Sylla Figueredo-Silva, Renata Cristina Pereira, Dyecika Souza Couto, Rosangela Correa Rodrigues, Taina de Abreu
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Veterinary Sciences
Tales Alexandre Aversi-Ferreira, Emmanuel Freitas-Ferreira, Roqueline A. G. M. F. Aversi-Ferreira
Summary: This study examined the arterial anatomy of the forelimbs of different primate groups, presenting a general arterial model in comparative terms. Mathematical formulas were used to explain the differences in the observed arterial patterns, particularly in relation to brachial artery division and the number of palmar arches. The findings provided hypotheses about the three observed models in terms of mathematical models.
JOURNAL OF MEDICAL PRIMATOLOGY
(2021)
Article
Veterinary Sciences
Sylla Figueredo-da-Silva, Ediana Vasconcelos-da-Silva, Taina Abreu, Tales Alexandre Aversi-Ferreira
Summary: The brachial plexus of the capuchin monkey is mainly formed by the ventral roots of the cervical and thoracic nerves, similar to that of Callithrix and baboons, possibly due to their quadrupedal nature.
JOURNAL OF MEDICAL PRIMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Tales Alexandre Aversi-Ferreira, Kellen Christina Malheiros Borges, Maria Tereza Goncalves-Mendes, Leonardo Ferreira Caixeta
Summary: The debate between genetic and cultural-social explanations for the origin of language is currently prominent, with anatomical studies showing promise in understanding the basis of language origin. Sapajus' longitudinal fascicle differs from other studied primates, indicating potential differences in the evolution of language.
Article
Multidisciplinary Sciences
Taina de Abreu, Maria Clotilde Henriques Tavares, Rafael Bretas, Rosangela Correa Rodrigues, Alcides Pissinati, Tales Alexandre Aversi-Ferreira
Summary: The study mainly focused on comparative neuroanatomy of New World Primates and morphological analysis of tropical Primates, with an attempt to establish a relationship between Old World Primates and modern humans based on the obtained data. Despite efforts to link the high cognition and abilities of Sapajus with neuroanatomical results through behavior and allometry, an intrinsic relation was not found in the deep neuroanatomic data obtained.
Article
Public, Environmental & Occupational Health
Ediana Vasconcelos da Silva, Kercio Jeaneryson Nogueira de Sousa Leite, Roqueline Ametila E. Gloria Martins De Freitas Aversi-Ferreira, Tales Alexandre Aversi-Ferreira
Summary: This study aimed to determine the incidence of orthopedic and traumatological problems in the region of Palmas, state of Tocantins (TO), Brazil, and found that most conditions were associated with scoliosis, which differs from most other studies. The study also indicated the need for training and management for the treatment of individuals over the age of 40. The importance of physiotherapists in prevention and primary care processes was evident from the patients in this study and other articles.
ACTA SCIENTIARUM-HEALTH SCIENCES
(2021)
Review
Neurosciences
Joao F. C. Pedrazzi, Frederico R. Ferreira, Danyelle Silva-Amaral, Daniel A. Lima, Jaime E. C. Hallak, Antonio W. Zuardi, Elaine A. Del-Bel, Francisco S. Guimaraes, Karla C. M. Costa, Alline C. Campos, Ana C. S. Crippa, Jose A. S. Crippa
Summary: This article reviews the potential of cannabidiol (CBD) as a treatment for the symptoms and comorbidities associated with autism spectrum disorder (ASD) based on preclinical and clinical data. The purpose is to provide information and discussion to avoid trivializing the use of this drug.
PSYCHOPHARMACOLOGY
(2022)
Article
Immunology
Glauce C. Nascimento, Bruna M. Santos, Joao F. Pedrazzi, Danyelle Silva-Amaral, Mariza Bortolanza, Grant T. Harris, Elaine Del Bel, Luiz G. S. Branco
Summary: Hydrogen gas inhalation reduces L-DOPA-induced dyskinesia by reducing inflammation, which has important implications for the treatment of Parkinson's disease.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2023)
Article
Anatomy & Morphology
Gabriel de Abreu Pfrimer, Taina de Abreu, Vanessa Souza Vieira, Nayane Peixoto Soares, Roqueline A. G. M. F. Aversi-Ferreira, Lucia Helena Almeida Gratao, Guilherme Nobre Lima do Nascimento, Hisao Nishijo, Tales Alexandre Aversi-Ferreira
INTERNATIONAL JOURNAL OF MORPHOLOGY
(2012)
