Microbiota-Gut-Brain Communication in the SARS-CoV-2 Infection

Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

(2021) Yun Kit Yeoh et al.   GUT

Cognitive decline among individuals with history of mild symptomatic SARS‐CoV‐2 infection: A longitudinal prospective study nested to a population cohort

(2021) Oscar H. Del Brutto et al.   EUROPEAN JOURNAL OF NEUROLOGY

Obesity as a Risk Factor for Severe COVID-19 and Complications: A Review

(2021) Fien Demeulemeester et al.   Cells

Sex-related patterns of the gut-microbiota-brain axis in the neuropsychiatric conditions

(2021) Luana M. Manosso et al.   BRAIN RESEARCH BULLETIN

Interleukin-6 as potential mediator of long-term neuropsychiatric symptoms of COVID-19

(2021) Nils Kappelmann et al.   PSYCHONEUROENDOCRINOLOGY

Efficacy of probiotics on cognition, and biomarkers of inflammation and oxidative stress in adults with Alzheimer’s disease or mild cognitive impairment — a meta-analysis of randomized controlled trials

(2020) Haoyue Den et al.   Aging-US

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

2019 novel coronavirus infection and gastrointestinal tract

(2020) Qin Yan Gao et al.   Journal of Digestive Diseases

The neuroinvasive potential of SARS‐CoV2 may be at least partially responsible for the respiratory failure of COVID‐19 patients

(2020) Yan‐Chao Li et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis

(2020) Bolin Wang et al.   Aging-US

Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China

(2020) Lei Pan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis

(2020) Brandon Michael Henry et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients

(2020) Xiaohua Chen et al.   CLINICAL INFECTIOUS DISEASES

Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China

(2020) Bo Li et al.   Clinical Research in Cardiology

Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization

(2020) Tao Zuo et al.   GASTROENTEROLOGY

Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis

(2020) Ka Shing Cheung et al.   GASTROENTEROLOGY

Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms

(2020) Xi Jin et al.   GUT

Gut microbiota and major depressive disorder: A systematic review and meta-analysis

(2020) Kenji Sanada et al.   JOURNAL OF AFFECTIVE DISORDERS

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Effects of COVID‐19 on Parkinson's disease clinical features: a community‐based case‐control study

(2020) Roberto Cilia et al.   MOVEMENT DISORDERS

COVID-19 and management of neuroimmunological disorders

(2020) Hans-Peter Hartung et al.   Nature Reviews Neurology

Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019

(2020) Adeel S. Zubair et al.   JAMA Neurology

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

(2020) Ling Mao et al.   JAMA Neurology

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

Gut microbiota and cardiovascular disease: opportunities and challenges

(2020) Negin Kazemian et al.   Microbiome

Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients

(2020) Jing Liu et al.   EBioMedicine

Probiotics and COVID-19: one size does not fit all

(2020) Joyce W Y Mak et al.   Lancet Gastroenterology & Hepatology

Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors

(2020) Mario Gennaro Mazza et al.   BRAIN BEHAVIOR AND IMMUNITY

Alterations of the Gut Microbiota in Patients With Coronavirus Disease 2019 or H1N1 Influenza

(2020) Silan Gu et al.   CLINICAL INFECTIOUS DISEASES

Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study

(2020) Bing Zhang et al.   GUT

Cytokine Storms: Understanding COVID-19

(2020) Nilam Mangalmurti et al.   IMMUNITY

Probiotics and Covid-19

(2020) Benedetta Bottari et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Probiotics and COVID‐19: is there any link?

(2020) A. Akour   LETTERS IN APPLIED MICROBIOLOGY

Extrapulmonary manifestations of COVID-19

(2020) Aakriti Gupta et al.   NATURE MEDICINE

Immune-mediated approaches against COVID-19

(2020) Helena F. Florindo et al.   Nature Nanotechnology

Prevalence of Psychological Morbidities Among General Population, Healthcare Workers and COVID-19 patients Amidst the COVID-19 Pandemic: A Systematic Review and Meta-Analysis

(2020) Yuvaraj Krishnamoorthy et al.   PSYCHIATRY RESEARCH

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Immediate and long-term consequences of COVID-19 infections for the development of neurological disease

(2020) Michael T. Heneka et al.   Alzheimers Research & Therapy

Is a “Cytokine Storm” Relevant to COVID-19?

(2020) Pratik Sinha et al.   JAMA Internal Medicine

Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention

(2020) John P. Hussman   Frontiers in Pharmacology

The COVID-19 Cytokine Storm; What We Know So Far

(2020) Dina Ragab et al.   Frontiers in Immunology

A Contemporary Review of Neurological Sequelae of COVID-19

(2020) Brian Fiani et al.   Frontiers in Neurology

Pulmonary and Extra-Pulmonary Clinical Manifestations of COVID-19

(2020) Kemmian D. Johnson et al.   Frontiers in Medicine

The prevalence of depression, anxiety, and sleep disturbances in COVID‐19 patients: a meta‐analysis

(2020) Jiawen Deng et al.   ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Role of probiotics to combat viral infections with emphasis on COVID-19

(2020) Aravind Sundararaman et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The expression of SARS-CoV-2 receptor ACE2 and CD147, and protease TMPRSS2 in human and mouse brain cells and mouse brain tissues

(2020) Jialu Qiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

(2020) Jessie Huang et al.   Cell Stem Cell

The lung tissue microbiota features of 20 deceased patients with COVID-19

(2020) Jun Fan et al.   JOURNAL OF INFECTION

The gut microbiota–brain axis in behaviour and brain disorders

(2020) Livia H. Morais et al.   NATURE REVIEWS MICROBIOLOGY

Lifting the mask on neurological manifestations of COVID-19

(2020) Alessandro Pezzini et al.   Nature Reviews Neurology

COVID-19 pandemic: Pathophysiology and manifestations from the gastrointestinal tract

(2020) Michail Galanopoulos et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Type 2 Diabetes Mellitus Associated with Obesity (Diabesity). The Central Role of Gut Microbiota and Its Translational Applications

(2020) Miguel A. Ortega et al.   Nutrients

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

(2020) Daniel E Leisman et al.   Lancet Respiratory Medicine

Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology

(2020) Deidiane Elisa Ribeiro et al.   MOLECULAR PSYCHIATRY

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19

(2020) Arianna Di Stadio et al.   Life-Basel

Leaky gut: mechanisms, measurement and clinical implications in humans

(2019) Michael Camilleri   GUT

The Impact of Chronic Intestinal Inflammation on Brain Disorders: the Microbiota-Gut-Brain Axis

(2019) Diana Serra et al.   MOLECULAR NEUROBIOLOGY

The role of short-chain fatty acids in microbiota–gut–brain communication

(2019) Boushra Dalile et al.   Nature Reviews Gastroenterology & Hepatology

Markers of central inflammation in major depressive disorder: A systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue

(2019) Daniela Enache et al.   BRAIN BEHAVIOR AND IMMUNITY

Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials

(2019) Richard T. Liu et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels

(2019) Emanuele Felice Osimo et al.   PSYCHOLOGICAL MEDICINE

Mood and Microbes

(2019) John R. Kelly et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases

(2019) Carolina Gubert et al.   NEUROBIOLOGY OF DISEASE

Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?

(2019) Marc Desforges et al.   Viruses-Basel

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

(2019) Koichiro Haruwaka et al.   Nature Communications

Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress

(2018) M. Vodička et al.   BRAIN BEHAVIOR AND IMMUNITY

Neurotransmitter modulation by the gut microbiota

(2018) Philip Strandwitz   BRAIN RESEARCH

The association between C-reactive protein, Interleukin-6 and depression among older adults in the community: A systematic review and meta-analysis

(2018) Kimberley J. Smith et al.   EXPERIMENTAL GERONTOLOGY

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Blood-brain barrier regulation in psychiatric disorders

(2018) John Kealy et al.   NEUROSCIENCE LETTERS

Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa

(2018) Robert Dantzer   PHYSIOLOGICAL REVIEWS

The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression

(2018) Piotr Czarny et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

(2018) Marion J. F. Levy et al.   PSYCHOPHARMACOLOGY

The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis

(2018) Bruno Bonaz et al.   Frontiers in Neuroscience

Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders

(2018) Sigrid Breit et al.   Frontiers in Psychiatry

Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis

(2018) Xi Chen et al.   Frontiers in Immunology

Depression

(2018) Gin S Malhi et al.   LANCET

Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism

(2018) Michela Barichella et al.   MOVEMENT DISORDERS

Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat in vitro Model

(2018) Yukari Shigemoto-Mogami et al.   Frontiers in Cellular Neuroscience

The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut

(2017) Bryan B. Yoo et al.   IMMUNITY

Neurotransmitters: The Critical Modulators Regulating Gut-Brain Axis

(2017) Rahul Mittal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Peripheral inflammatory markers in Alzheimer’s disease: a systematic review and meta-analysis of 175 studies

(2017) Ka Sing P Lai et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The mucosal immune system: master regulator of bidirectional gut–brain communications

(2017) Nick Powell et al.   Nature Reviews Gastroenterology & Hepatology

The immunology of atherosclerosis

(2017) Anton Gisterå et al.   Nature Reviews Nephrology

Genes and Gut Bacteria Involved in Luminal Butyrate Reduction Caused by Diet and Loperamide

(2017) Nakwon Hwang et al.   Genes

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Neurovascular Unit Dysfunction and Blood–Brain Barrier Hyperpermeability Contribute to Schizophrenia Neurobiology: A Theoretical Integration of Clinical and Experimental Evidence

(2017) Souhel Najjar et al.   Frontiers in Psychiatry

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

Controversies Revisited

(2016) Antonina Mikocka-Walus et al.   INFLAMMATORY BOWEL DISEASES

Morganella morganii, a non-negligent opportunistic pathogen

(2016) Hui Liu et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

(2016) John R. Kelly et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Probiotics for prevention and treatment of respiratory tract infections in children

(2016) Yizhong Wang et al.   MEDICINE

Signals from the gut microbiota to distant organs in physiology and disease

(2016) Bjoern O Schroeder et al.   NATURE MEDICINE

The bowel and beyond: the enteric nervous system in neurological disorders

(2016) Meenakshi Rao et al.   Nature Reviews Gastroenterology & Hepatology

The Gut-Brain Axis, BDNF, NMDA and CNS Disorders

(2016) Raeesah Maqsood et al.   NEUROCHEMICAL RESEARCH

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease

(2016) Xiao-Yan Qin et al.   JAMA Neurology

So depression is an inflammatory disease, but where does the inflammation come from?

(2016) Michael Berk et al.   BMC Medicine

Irritable Bowel Syndrome Is Associated with an Increased Risk of Dementia: A Nationwide Population-Based Study

(2016) Chien-Hua Chen et al.   PLoS One

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

(2015) S.M. O’Mahony et al.   BEHAVIOURAL BRAIN RESEARCH

Altered fecal microbiota composition in patients with major depressive disorder

(2015) Haiyin Jiang et al.   BRAIN BEHAVIOR AND IMMUNITY

Constipation preceding Parkinson's disease: a systematic review and meta-analysis

(2015) Kerala L Adams-Carr et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

Acinetobacter baumannii: Evolution of Antimicrobial Resistance—Treatment Options

(2015) Gerald Murray et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Insights into the Role of Erysipelotrichaceae in the Human Host

(2015) Nadeem O. Kaakoush   Frontiers in Cellular and Infection Microbiology

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis

(2014) Guillaume Fond et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Murimonas intestini gen. nov., sp. nov., an acetate-producing bacterium of the family Lachnospiraceae isolated from the mouse gut

(2014) K. Klaring et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Rothia Bacteremia: a 10-Year Experience at Mayo Clinic, Rochester, Minnesota

(2014) Poornima Ramanan et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Correlation between the human fecal microbiota and depression

(2014) A. Naseribafrouei et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals

(2013) Nicholas P. West et al.   CLINICAL NUTRITION

Faecalibacterium prausnitzii and human intestinal health

(2013) S Miquel et al.   CURRENT OPINION IN MICROBIOLOGY

Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence

(2013) Souhel Najjar et al.   Journal of Neuroinflammation

ACE2 – From the renin–angiotensin system to gut microbiota and malnutrition

(2013) Thomas Perlot et al.   MICROBES AND INFECTION

Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine

(2013) Helene M. Savignac et al.   NEUROCHEMISTRY INTERNATIONAL

Gut–brain axis: how the microbiome influences anxiety and depression

(2013) Jane A. Foster et al.   TRENDS IN NEUROSCIENCES

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

(2012) Tatsuo Hashimoto et al.   NATURE

Neuropsychiatric symptoms in Alzheimer’s disease

(2011) Constantine G. Lyketsos et al.   Alzheimers & Dementia

Suppression of oxLDL-Induced MMP-9 and EMMPRIN Expression by Berberine via Inhibition of NF-κB Activation in Human THP-1 Macrophages

(2011) Zhouqing Huang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Gut feelings: the emerging biology of gut–brain communication

(2011) Emeran A. Mayer   NATURE REVIEWS NEUROSCIENCE

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Cyclophilin-CD147 interactions: a new target for anti-inflammatory therapeutics

(2010) V. Yurchenko et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Obesity, Diabetes, and Gut Microbiota: The hygiene hypothesis expanded?

(2010) G. Musso et al.   DIABETES CARE

Glutamate receptors, neurotoxicity and neurodegeneration

(2010) Anthony Lau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Gut Microbiota in Health and Disease

(2010) Inna Sekirov et al.   PHYSIOLOGICAL REVIEWS

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Angiotensin-converting enzyme 2 in the brain: properties and future directions

(2008) Huijing Xia et al.   JOURNAL OF NEUROCHEMISTRY

A glimmer of light for neuropsychiatric disorders

(2008) Steven E. Hyman   NATURE

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE