Biomaterial-assisted biotherapy: A brief review of biomaterials used in drug delivery, vaccine development, gene therapy, and stem cell therapy

In Situ Programming of CAR T Cells

(2021) Neha N. Parayath et al.   Annual Review of Biomedical Engineering

Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19

(2021) Brian J. Ward et al.   NATURE MEDICINE

Highly branched poly(β-amino ester)s for gene delivery in hereditary skin diseases

(2021) Ming Zeng et al.   ADVANCED DRUG DELIVERY REVIEWS

The current landscape of nucleic acid therapeutics

(2021) Jayesh A. Kulkarni et al.   Nature Nanotechnology

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

(2021) Namit Chaudhary et al.   NATURE REVIEWS DRUG DISCOVERY

In situ subcutaneously injectable thermosensitive PEG-PLGA diblock and PLGA-PEG-PLGA triblock copolymer composite as sustained delivery of bispecific anti-CD3 scFv T-cell/anti-EGFR Fab Engager (BiTEE)

(2021) Pu-Sheng Wei et al.   BIOMATERIALS

Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy

(2020) Yazhe Wang et al.   ACS Applied Materials & Interfaces

Self-Assembled Nanoparticles Prepared from Low-Molecular-Weight PEI and Low-Generation PAMAM for EGFRvIII-Chimeric Antigen Receptor Gene Loading and T-Cell Transient Modification

(2020) Qianru Yu et al.   International Journal of Nanomedicine

Developing Implantable Scaffolds to Enhance Neural Stem Cell Therapy for Post-Operative Glioblastoma

(2020) Kevin T. Sheets et al.   MOLECULAR THERAPY

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

(2020) Margaret M. Billingsley et al.   NANO LETTERS

Delivery of CRISPR/Cas systems for cancer gene therapy and immunotherapy

(2020) Xiangrong Song et al.   ADVANCED DRUG DELIVERY REVIEWS

Endo/Lysosome‐Escapable Delivery Depot for Improving BBB Transcytosis and Neuron Targeted Therapy of Alzheimer's Disease

(2020) Lulu Cai et al.   ADVANCED FUNCTIONAL MATERIALS

Enabling sublingual peptide immunization with molecular self-assemblies

(2020) Sean H. Kelly et al.   BIOMATERIALS

Antifibrotic strategies for medical devices

(2020) Nicholas G. Welch et al.   ADVANCED DRUG DELIVERY REVIEWS

Controlling timing and location in vaccines

(2020) Darrell J. Irvine et al.   ADVANCED DRUG DELIVERY REVIEWS

Colloidal systems toward 3D cell culture scaffolds

(2020) Christian Vila-Parrondo et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

(2020) Jingyun Yang et al.   NATURE

The dose threshold for nanoparticle tumour delivery

(2020) Ben Ouyang et al.   NATURE MATERIALS

An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

(2020) Jesse H. Erasmus et al.   Science Translational Medicine

Current Challenges in Vaccinology

(2020) Richard B. Kennedy et al.   Frontiers in Immunology

Local and Targeted Delivery of Immune Checkpoint Blockade Therapeutics

(2020) Xiao Han et al.   ACCOUNTS OF CHEMICAL RESEARCH

Chitosan/γ-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer

(2020) Flávia Castro et al.   BIOMATERIALS

Polymeric nanoparticle vaccines to combat emerging and pandemic threats

(2020) David Wibowo et al.   BIOMATERIALS

Knowledge gaps in immune response and immunotherapy involving nanomaterials: Databases and artificial intelligence for material design

(2020) Ruihong Feng et al.   BIOMATERIALS

Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models

(2020) Min-Wen Ku et al.   Cell Host & Microbe

Considerations for designing preclinical cancer immune nanomedicine studies

(2020) Wen Jiang et al.   Nature Nanotechnology

In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo

(2020) N. N. Parayath et al.   Nature Communications

Automation and data-driven design of polymer therapeutics

(2020) Rahul Upadhya et al.   ADVANCED DRUG DELIVERY REVIEWS

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical-grade stem cell–derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs

(2019) Ruchi Sharma et al.   Science Translational Medicine

Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness

(2019) Fei Peng et al.   Nature Nanotechnology

Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells

(2019) Elena Garreta et al.   NATURE MATERIALS

Peptide-based Autophagic Gene and Cisplatin Co-delivery Systems Enable Improve Chemotherapy Resistance

(2019) Yaoxin Lin et al.   NANO LETTERS

Gold Nanoparticle-Integrated Scaffolds for Tissue Engineering and Regenerative Medicine

(2019) Moran Yadid et al.   NANO LETTERS

Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma

(2019) Seyed Nasrollah Tabatabaei et al.   JOURNAL OF CONTROLLED RELEASE

Composition design and medical application of liposomes

(2019) Mingyuan Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling

(2019) Yimu Zhao et al.   CELL

Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect

(2019) Yuxiao Lai et al.   BIOMATERIALS

Lipid-Based DNA Therapeutics – Hallmarks of Non-Viral Gene Delivery

(2019) Jonas Buck et al.   ACS Nano

Delivery of microRNAs by Chitosan Nanoparticles to Functionally Alter Macrophage Cholesterol Efflux In Vitro and In Vivo

(2019) My-Anh Nguyen et al.   ACS Nano

Strategies, design, and chemistry in siRNA delivery systems

(2019) Yizhou Dong et al.   ADVANCED DRUG DELIVERY REVIEWS

Multi-stimuli responsive nanosystem modified by tumor-targeted carbon dots for chemophototherapy synergistic therapy

(2019) Xiudan Wang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Bioactive site-specifically modified proteins for 4D patterning of gel biomaterials

(2019) Jared A. Shadish et al.   NATURE MATERIALS

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

(2019) Kimberly J. Hassett et al.   Molecular Therapy-Nucleic Acids

Systemic miRNA delivery by nontoxic nanoscale coordination polymers limits epithelial-to-mesenchymal transition and suppresses liver metastases of colorectal cancer

(2019) Christina Chan et al.   BIOMATERIALS

A boronic acid–rich dendrimer with robust and unprecedented efficiency for cytosolic protein delivery and CRISPR-Cas9 gene editing

(2019) Chongyi Liu et al.   Science Advances

Efficient and Robust Highly Branched Poly(β-amino ester)/Minicircle COL7A1 Polymeric Nanoparticles for Gene Delivery to Recessive Dystrophic Epidermolysis Bullosa Keratinocytes

(2019) Ming Zeng et al.   ACS Applied Materials & Interfaces

Ultrasound/microbubble-mediated targeted delivery of anticancer microRNA-loaded nanoparticles to deep tissues in pigs

(2019) Tommaso Di Ianni et al.   JOURNAL OF CONTROLLED RELEASE

Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues

(2019) Ruoxiao Xie et al.   Small

Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer

(2019) Theofilus A. Tockary et al.   ACS Nano

In situ repurposing of dendritic cells with CRISPR/Cas9-based nanomedicine to induce transplant tolerance

(2019) Yue Zhang et al.   BIOMATERIALS

Bioinspired surface modification of orthopedic implants for bone tissue engineering

(2019) Chao Hu et al.   BIOMATERIALS

Multifunctional nanoparticles for genetic engineering and bioimaging of natural killer (NK) cell therapeutics

(2019) Kwang-Soo Kim et al.   BIOMATERIALS

Remote Light‐Responsive Nanocarriers for Controlled Drug Delivery: Advances and Perspectives

(2019) Wei Zhao et al.   Small

Deterministic Encapsulation of Human Cardiac Stem Cells in Variable Composition Nanoporous Gel Cocoons To Enhance Therapeutic Repair of Injured Myocardium

(2018) Pushpinder Kanda et al.   ACS Nano

Thermo-triggered Release of CRISPR-Cas9 System by Lipid-Encapsulated Gold Nanoparticles for Tumor Therapy

(2018) Peng Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transfection of gene regulation nanoparticles complexed with pDNA and shRNA controls multilineage differentiation of hMSCs

(2018) Hye Jin Kim et al.   BIOMATERIALS

Structure-based design for binding peptides in anti-cancer therapy

(2018) Sheng-Hung Wang et al.   BIOMATERIALS

Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities

(2018) Ling Li et al.   BIOMATERIALS

Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds

(2018) Ammad Ahmad Farooqi et al.   BIOTECHNOLOGY ADVANCES

Targeted delivery of microRNA-199a-3p using self-assembled dipeptide nanoparticles efficiently reduces hepatocellular carcinoma in mice

(2018) Aditi Varshney et al.   HEPATOLOGY

Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

(2018) Claudia Allemani et al.   LANCET

Efficient gene editing via non-viral delivery of CRISPR–Cas9 system using polymeric and hybrid microcarriers

(2018) Alexander S. Timin et al.   Nanomedicine-Nanotechnology Biology and Medicine

Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration

(2018) Lyndon da Cruz et al.   NATURE BIOTECHNOLOGY

A facile approach to enhance antigen response for personalized cancer vaccination

(2018) Aileen Weiwei Li et al.   NATURE MATERIALS

Improving Vaccine and Immunotherapy Design Using Biomaterials

(2018) Michelle L. Bookstaver et al.   TRENDS IN IMMUNOLOGY

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization

(2018) Susan Hua et al.   Frontiers in Pharmacology

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

(2018) Christopher B. Rodell et al.   Nature Biomedical Engineering

Acellular and cellular approaches to improve diabetic wound healing

(2018) Hongkwan Cho et al.   ADVANCED DRUG DELIVERY REVIEWS

Aptamer-guided nanomedicines for anticancer drug delivery

(2018) Walhan Alshaer et al.   ADVANCED DRUG DELIVERY REVIEWS

Hyaluronic acid-functionalized half-generation of sectorial dendrimers for anticancer drug delivery and enhanced biocompatibility

(2018) Xiao Du et al.   CARBOHYDRATE POLYMERS

Patisiran: First Global Approval

(2018) Sheridan M. Hoy   DRUGS

Nanoparticle Delivery of miRNA-21 Mimic to Cardiac Macrophages Improves Myocardial Remodeling after Myocardial Infarction

(2018) Tzlil Bejerano et al.   NANO LETTERS

Cancer Theranostic Applications of Albumin-Coated Tobacco Mosaic Virus Nanoparticles

(2018) A. S. Pitek et al.   ACS Applied Materials & Interfaces

Stimuli-Responsive Nano-Architecture Drug-Delivery Systems to Solid Tumor Micromilieu: Past, Present, and Future Perspectives

(2018) Hossam S. El-Sawy et al.   ACS Nano

Biomaterials for vaccine-based cancer immunotherapy

(2018) Rui Zhang et al.   JOURNAL OF CONTROLLED RELEASE

In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR/dCas9

(2018) Zhelong Li et al.   NANO LETTERS

Manipulation of Transgene Expression in Fibroblast Cells by a Multifunctional Linear-Branched Hybrid Poly(β-Amino Ester) Synthesized through an Oligomer Combination Approach

(2018) Ming Zeng et al.   NANO LETTERS

Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors

(2017) Tyrel T. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Endosomal Escape and Delivery of CRISPR/Cas9 Genome Editing Machinery Enabled by Nanoscale Zeolitic Imidazolate Framework

(2017) Shahad K. Alsaiari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Poly-beta-amino-esters nano-vehicles based drug delivery system for cartilage

(2017) Stefano Perni et al.   Nanomedicine-Nanotechnology Biology and Medicine

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

(2017) Xue Gao et al.   NATURE

Maintenance of neural progenitor cell stemness in 3D hydrogels requires matrix remodelling

(2017) Christopher M. Madl et al.   NATURE MATERIALS

Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

(2017) Nelly M. Cruz et al.   NATURE MATERIALS

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

(2017) Tyrel T. Smith et al.   Nature Nanotechnology

Shear-thinning and self-healing hydrogels as injectable therapeutics and for 3D-printing

(2017) Claudia Loebel et al.   Nature Protocols

Fabrication of fillable microparticles and other complex 3D microstructures

(2017) Kevin J. McHugh et al.   SCIENCE

Making Mouse Models That Reflect Human Immune Responses

(2017) Lili Tao et al.   TRENDS IN IMMUNOLOGY

Synthetically controlling dendrimer flexibility improves delivery of large plasmid DNA

(2017) Jessica A. Kretzmann et al.   Chemical Science

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

(2017) Daniela Schmid et al.   Nature Communications

Multicomponent Injectable Hydrogels for Antigen-Specific Tolerogenic Immune Modulation

(2017) Catia S. Verbeke et al.   Advanced Healthcare Materials

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell–Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine

(2017) Ling Gao et al.   CIRCULATION

Sliding Fibers: Slidable, Injectable, and Gel-like Electrospun Nanofibers as Versatile Cell Carriers

(2016) Slgirim Lee et al.   ACS Nano

Artificial Virus Delivers CRISPR-Cas9 System for Genome Editing of Cells in Mice

(2016) Ling Li et al.   ACS Nano

Surface-Adaptive, Antimicrobially Loaded, Micellar Nanocarriers with Enhanced Penetration and Killing Efficiency in Staphylococcal Biofilms

(2016) Yong Liu et al.   ACS Nano

PGMA-Based Star-Like Polycations with Plentiful Hydroxyl Groups Act as Highly Efficient miRNA Delivery Nanovectors for Effective Applications in Heart Diseases

(2016) Rui-Quan Li et al.   ADVANCED MATERIALS

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA

(2016) Jason B. Miller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced non-inflammasome mediated immune responses by mannosylated zwitterionic-based cationic liposomes for HIV DNA vaccines

(2016) Chenmeng Qiao et al.   BIOMATERIALS

Chitosan thermogels for local expansion and delivery of tumor-specific T lymphocytes towards enhanced cancer immunotherapies

(2016) Anne Monette et al.   BIOMATERIALS

Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review

(2016) Manju Kanamala et al.   BIOMATERIALS

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

(2016) Yu Shrike Zhang et al.   BIOMATERIALS

CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

(2016) Daniel P. Dever et al.   NATURE

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

(2016) Hao Yin et al.   NATURE BIOTECHNOLOGY

Defined three-dimensional microenvironments boost induction of pluripotency

(2016) Massimiliano Caiazzo et al.   NATURE MATERIALS

Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche

(2016) Yue Shao et al.   NATURE MATERIALS

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

(2016) Saeid Zanganeh et al.   Nature Nanotechnology

Synthetic biology to access and expand nature's chemical diversity

(2016) Michael J. Smanski et al.   NATURE REVIEWS MICROBIOLOGY

P-selectin is a nanotherapeutic delivery target in the tumor microenvironment

(2016) Y. Shamay et al.   Science Translational Medicine

Human Phase 1 trial of low-dose inactivated seasonal influenza vaccine formulated with Advax™ delta inulin adjuvant

(2016) David L. Gordon et al.   VACCINE

Activated dendritic cells delivered in tissue compatible biomatrices induce in-situ anti-tumor CTL responses leading to tumor regression

(2016) Vivek Verma et al.   Oncotarget

Generation of protective immunity against Orientia tsutsugamushi infection by immunization with a zinc oxide nanoparticle combined with ScaA antigen

(2016) Na-Young Ha et al.   JOURNAL OF NANOBIOTECHNOLOGY

The transition from linear to highly branched poly( -amino ester)s: Branching matters for gene delivery

(2016) D. Zhou et al.   Science Advances

Nanohybrid Liposomal Cerasomes with Good Physiological Stability and Rapid Temperature Responsiveness for High Intensity Focused Ultrasound Triggered Local Chemotherapy of Cancer

(2015) Xiaolong Liang et al.   ACS Nano

3D-printed hierarchical scaffold for localized isoniazid/rifampin drug delivery and osteoarticular tuberculosis therapy

(2015) Min Zhu et al.   Acta Biomaterialia

Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy

(2015) Harutaka Mekaru et al.   ADVANCED DRUG DELIVERY REVIEWS

Injectable Hydrogels with In Situ Double Network Formation Enhance Retention of Transplanted Stem Cells

(2015) Lei Cai et al.   ADVANCED FUNCTIONAL MATERIALS

Active Targeting of Tumors through Conformational Epitope Imprinting

(2015) Yan Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing

(2015) Wujin Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A highly tumor-targeted nanoparticle of podophyllotoxin penetrated tumor core and regressed multidrug resistant tumors

(2015) Aniruddha Roy et al.   BIOMATERIALS

Silica-based nanocapsules: synthesis, structure control and biomedical applications

(2015) Yu Zhang et al.   CHEMICAL SOCIETY REVIEWS

Polymeric nanoparticles for co-delivery of synthetic long peptide antigen and poly IC as therapeutic cancer vaccine formulation

(2015) Sima Rahimian et al.   JOURNAL OF CONTROLLED RELEASE

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

(2015)   LANCET

Landmark green light for Mosquirix malaria vaccine

(2015) Chris Morrison   NATURE BIOTECHNOLOGY

Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation

(2015) Nathaniel Huebsch et al.   NATURE MATERIALS

Stress-stiffening-mediated stem-cell commitment switch in soft responsive hydrogels

(2015) Rajat K. Das et al.   NATURE MATERIALS

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Injectable cryogel-based whole-cell cancer vaccines

(2015) Sidi A. Bencherif et al.   Nature Communications

Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity

(2015) Yongkui Li et al.   OncoImmunology

Mechanical properties and dual drug delivery application of poly(lactic-co-glycolic acid) scaffolds fabricated with a poly(β-amino ester) porogen

(2014) Amanda Clark et al.   Acta Biomaterialia

Targeting and activation of antigen-specific B-cells by calcium phosphate nanoparticles loaded with protein antigen

(2014) Vladimir V. Temchura et al.   BIOMATERIALS

Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart

(2014) Ellen T. Roche et al.   BIOMATERIALS

Microbial biosynthesis of designer outer membrane vesicles

(2014) Jenny L Baker et al.   CURRENT OPINION IN BIOTECHNOLOGY

Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA

(2014) S. Ramakrishna et al.   GENOME RESEARCH

Cancer active targeting by nanoparticles: a comprehensive review of literature

(2014) Remon Bazak et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Evolution of implantable and insertable drug delivery systems

(2014) Lothar W. Kleiner et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle-Assisted Targeted Delivery of Eye-Specific Genes to Eyes Significantly Improves the Vision of Blind Mice In Vivo

(2014) Ammaji Rajala et al.   NANO LETTERS

Biopolymer implants enhance the efficacy of adoptive T-cell therapy

(2014) Sirkka B Stephan et al.   NATURE BIOTECHNOLOGY

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

(2014) John A Zuris et al.   NATURE BIOTECHNOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Enhanced Immune Response and Protective Effects of Nano-chitosan-based DNA Vaccine Encoding T Cell Epitopes of Esat-6 and FL against Mycobacterium Tuberculosis Infection

(2014) Ganzhu Feng et al.   PLoS One

Immunogenicity and safety of Advax™, a novel polysaccharide adjuvant based on delta inulin, when formulated with hepatitis B surface antigen: A randomized controlled Phase 1 study

(2014) David Gordon et al.   VACCINE

Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice

(2014) Christopher M. Coleman et al.   VACCINE

Mucosal vaccination against tuberculosis using Ag85A-loaded immunostimulating complexes

(2014) Swati Pabreja et al.   Artificial Cells Nanomedicine and Biotechnology

Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo

(2013) Kenichi Niikura et al.   ACS Nano

Engineering an Effective Immune Adjuvant by Designed Control of Shape and Crystallinity of Aluminum Oxyhydroxide Nanoparticles

(2013) Bingbing Sun et al.   ACS Nano

A Multi-Component Meningococcal Serogroup B Vaccine (4CMenB): The Clinical Development Program

(2013) Miguel O’Ryan et al.   DRUGS

Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format

(2013) Kyle K.L. Phua et al.   JOURNAL OF CONTROLLED RELEASE

Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-small-cell lung cancer (START): a randomised, double-blind, phase 3 trial

(2013) Charles Butts et al.   LANCET ONCOLOGY

Gold nanoparticle–M2e conjugate coformulated with CpG induces protective immunity against influenza A virus

(2013) Wenqian Tao et al.   Nanomedicine

Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle

(2013) S. Eliasof et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of the immune responses to Treponema pallidum Gpd DNA vaccine adjuvanted with IL-2 and chitosan nanoparticles before and after Treponema pallidum challenge in rabbits

(2013) FeiJun Zhao et al.   Science China-Life Sciences

Vaccine adjuvant formulations: A pharmaceutical perspective

(2013) Luis A. Brito et al.   SEMINARS IN IMMUNOLOGY

Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin

(2013) M.I. Setyawati et al.   Nature Communications

Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages

(2012) Shann Yu et al.   International Journal of Nanomedicine

Enhanced mucosal and systemic immune responses obtained by porous silica nanoparticles used as an oral vaccine adjuvant: Effect of silica architecture on immunological properties

(2012) Tianyi Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

ISCOMATRIX: a novel adjuvant for use in prophylactic and therapeutic vaccines against infectious diseases

(2012) A. Baz Morelli et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment

(2012) Ligeng Xu et al.   NANO LETTERS

Stem cell therapy for voiding and erectile dysfunction

(2012) Martin Vaegler et al.   Nature Reviews Urology

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

(2012) J. Hrkach et al.   Science Translational Medicine

A Review of Clinical Trials of Human Papillomavirus Prophylactic Vaccines

(2012) John T. Schiller et al.   VACCINE

Single-Walled Carbon Nanotubes Deliver Peptide Antigen into Dendritic Cells and Enhance IgG Responses to Tumor-Associated Antigens

(2011) Carlos H. Villa et al.   ACS Nano

Synthesis of a novel kind of carbon nanoparticle with large mesopores and macropores and its application as an oral vaccine adjuvant

(2011) Tianyi Wang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

In Vitroandin VivomRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles

(2011) Xingfang Su et al.   MOLECULAR PHARMACEUTICS

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Alginate: Properties and biomedical applications

(2011) Kuen Yong Lee et al.   PROGRESS IN POLYMER SCIENCE

Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles

(2010) Adam Kulp et al.   Annual Review of Microbiology

Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles

(2010) T. N. Ellis et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Aerosolized PLA and PLGA Nanoparticles Enhance Humoral, Mucosal and Cytokine Responses to Hepatitis B Vaccine

(2010) Chandan Thomas et al.   MOLECULAR PHARMACEUTICS

Regulatory T-Cell-Mediated Attenuation of T-Cell Responses to the NY-ESO-1 ISCOMATRIX Vaccine in Patients with Advanced Malignant Melanoma

(2009) T. Nicholaou et al.   CLINICAL CANCER RESEARCH

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Cytotoxicity and Immunological Response of Gold and Silver Nanoparticles of Different Sizes

(2009) Hung-Jen Yen et al.   Small

A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery

(2008) Jordan J. Green et al.   ACCOUNTS OF CHEMICAL RESEARCH

Immune response by nasal delivery of hepatitis B surface antigen and codelivery of a CpG ODN in alginate coated chitosan nanoparticles

(2008) Olga Borges et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS