- Home
- Publications
- Publication Search
- Publication Details
Title
The glymphatic hypothesis: the theory and the evidence
Authors
Keywords
-
Journal
Fluids and Barriers of the CNS
Volume 19, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-02-04
DOI
10.1186/s12987-021-00282-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics
- (2021) Steven T. Proulx CELLULAR AND MOLECULAR LIFE SCIENCES
- Mapping of CSF transport using high spatiotemporal resolution dynamic contrast‐enhanced MRI in mice: Effect of anesthesia
- (2021) Evan Hunter Stanton et al. MAGNETIC RESONANCE IN MEDICINE
- Harnessing Cerebrospinal Fluid Circulation for Drug Delivery to Brain Tissues
- (2021) Ghazal Naseri Kouzehgarani et al. ADVANCED DRUG DELIVERY REVIEWS
- Mechanisms of tracer transport in cerebral perivascular spaces
- (2021) Mohammad M. Faghih et al. JOURNAL OF BIOMECHANICS
- Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain
- (2021) Daniel E. Troyetsky et al. Scientific Reports
- Glymphatic System as a Gateway to Connect Neurodegeneration From Periphery to CNS
- (2021) Gianfranco Natale et al. Frontiers in Neuroscience
- Coupled Neural, Vascular, and Cerebrospinal Fluid Dynamics in Human Sleep
- (2021) Nina Fultz et al. BIOLOGICAL PSYCHIATRY
- Clinical application of intrathecal gadobutrol for assessment of cerebrospinal fluid tracer clearance to blood
- (2021) Per K. Eide et al. JCI Insight
- Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake
- (2021) Alex J. Smith et al. JOURNAL OF GENERAL PHYSIOLOGY
- Cerebral small vessel disease: A glymphopathy?
- (2021) Helene Benveniste et al. CURRENT OPINION IN NEUROBIOLOGY
- Perivascular spaces in the brain: anatomy, physiology and pathology
- (2020) Joanna M. Wardlaw et al. Nature Reviews Neurology
- Vasomotion Drives Periarterial Drainage of Aβ from the Brain
- (2020) Roxana O. Carare et al. NEURON
- Cerebrospinal fluid influx drives acute ischemic tissue swelling
- (2020) Humberto Mestre et al. SCIENCE
- Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus
- (2020) Benjamin C. Reeves et al. TRENDS IN MOLECULAR MEDICINE
- Cerebrospinal fluid tracer efflux to parasagittal dura in humans
- (2020) Geir Ringstad et al. Nature Communications
- Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain
- (2020) William M. Pardridge Frontiers in Aging Neuroscience
- Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model
- (2020) Ian F Harrison et al. BRAIN
- Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling
- (2020) Federico N. Soria et al. Nature Communications
- Apparent diffusion coefficient estimates based on 24 hours tracer movement support glymphatic transport in human cerebral cortex
- (2020) Lars Magnus Valnes et al. Scientific Reports
- Arterial pulsations drive oscillatory flow of CSF but not directional pumping
- (2020) Ravi Teja Kedarasetti et al. Scientific Reports
- Omega-3 Polyunsaturated Fatty Acids Alleviate Traumatic Brain Injury by Regulating the Glymphatic Pathway in Mice
- (2020) Erwei Zhang et al. Frontiers in Neurology
- Varying perivascular astroglial endfoot dimensions along the vascular tree maintain perivascular‐interstitial flux through the cortical mantle
- (2020) Marie Xun Wang et al. GLIA
- The glymphatic system and its role in cerebral homeostasis
- (2020) Helene Benveniste et al. JOURNAL OF APPLIED PHYSIOLOGY
- Respiratory cerebrospinal fluid flow is driven by the thoracic and lumbar spinal pressures
- (2020) Robert A. Lloyd et al. JOURNAL OF PHYSIOLOGY-LONDON
- Contrast-enhanced magnetic resonance imaging evidence for the role of astrocytic aquaporin-4 water channels in glymphatic influx and interstitial solute transport
- (2020) Kazuki Takano et al. MAGNETIC RESONANCE IMAGING
- Glymphatic failure as a final common pathway to dementia
- (2020) Maiken Nedergaard et al. SCIENCE
- In vivo T1 mapping for quantifying glymphatic system transport and cervical lymph node drainage
- (2020) Yuechuan Xue et al. Scientific Reports
- Defining novel functions for cerebrospinal fluid in ALS pathophysiology
- (2020) Koy Chong Ng Kee Kwong et al. Acta Neuropathologica Communications
- Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain
- (2019) Roxana Aldea et al. Frontiers in Aging Neuroscience
- Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein
- (2019) Wenyan Zou et al. Translational Neurodegeneration
- Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia
- (2019) Lauren M. Hablitz et al. Science Advances
- Glymphatic System Function in Relation to Anesthesia and Sleep States
- (2019) Helene Benveniste et al. ANESTHESIA AND ANALGESIA
- When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow
- (2019) Benjamin A. Plog et al. JOURNAL OF NEUROSURGERY
- Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson’s disease
- (2019) Saranya Sundaram et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Linking Traumatic Brain Injury, Sleep Disruption and Post-Traumatic Headache: a Potential Role for Glymphatic Pathway Dysfunction
- (2019) Juan Piantino et al. Current Pain and Headache Reports
- Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs
- (2019) Tuomas O. Lilius et al. JOURNAL OF CONTROLLED RELEASE
- Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid
- (2019) Ji Hoon Ahn et al. NATURE
- Dispersion in porous media in oscillatory flow between flat plates: applications to intrathecal, periarterial and paraarterial solute transport in the central nervous system
- (2019) M. Keith Sharp et al. Fluids and Barriers of the CNS
- Is solute movement within the extracellular spaces of brain gray matter brought about primarily by diffusion or flow? A commentary on “Analysis of convective and diffusive transport in the brain interstitium” Fluids and Barriers of the CNS (2019) 16:6 by L. Ray, J.J. Iliff and J.J. Heys
- (2019) Stephen B. Hladky et al. Fluids and Barriers of the CNS
- Vasomotor influences on glymphatic-lymphatic coupling and solute trafficking in the central nervous system
- (2019) James R Goodman et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- CrossTalk opposing view: Going against the flow: interstitial solute transport in brain is diffusive and aquaporin‐4 independent
- (2019) Alex J. Smith et al. JOURNAL OF PHYSIOLOGY-LONDON
- Uncertainty quantification of parenchymal tracer distribution using random diffusion and convective velocity fields
- (2019) Matteo Croci et al. Fluids and Barriers of the CNS
- Computational modelling of fluid and solute transport in the brain
- (2019) Adam D. Martinac et al. Biomechanics and Modeling in Mechanobiology
- Letter to the Editor. Cerebrospinal fluid circulation failure in the pathogenesis of post-craniectomy glymphatic flow impairment
- (2019) Pasquale Gallina et al. JOURNAL OF NEUROSURGERY
- Fluid dynamics of cerebrospinal fluid flow in perivascular spaces
- (2019) John H. Thomas Journal of the Royal Society Interface
- Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways
- (2019) Steven M. Greenberg et al. Nature Reviews Neurology
- Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain
- (2019) Susanne J. van Veluw et al. NEURON
- Meningeal lymphatics, immunity and neuroinflammation
- (2019) Natalie Frederick et al. CURRENT OPINION IN NEUROBIOLOGY
- Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways
- (2018) Nazira J. Albargothy et al. ACTA NEUROPATHOLOGICA
- The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?
- (2018) N. Joan Abbott et al. ACTA NEUROPATHOLOGICA
- The meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS
- (2018) Roy O. Weller et al. ACTA NEUROPATHOLOGICA
- The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future
- (2018) Benjamin A. Plog et al. Annual Review of Pathology-Mechanisms of Disease
- The Emerging Relationship Between Interstitial Fluid–Cerebrospinal Fluid Exchange, Amyloid-β, and Sleep
- (2018) Erin L. Boespflug et al. BIOLOGICAL PSYCHIATRY
- The “glymphatic” mechanism for solute clearance in Alzheimer’s disease: game changer or unproven speculation?
- (2018) Alex J. Smith et al. FASEB JOURNAL
- Aquaporin-4 facilitator TGN-073 promotes interstitial fluid circulation within the blood–brain barrier
- (2018) Vincent J. Huber et al. NEUROREPORT
- Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer’s dementia subjects
- (2018) James R. Goodman et al. BRAIN BEHAVIOR AND IMMUNITY
- Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease
- (2018) Sandro Da Mesquita et al. NATURE
- Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI
- (2018) Ian F Harrison et al. eLife
- Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain
- (2018) Qiaoli Ma et al. ACTA NEUROPATHOLOGICA
- Paravascular spaces: entry to or exit from the brain?
- (2018) Erik N. T. P. Bakker et al. EXPERIMENTAL PHYSIOLOGY
- The glymphatic pathway in neurological disorders
- (2018) Martin Kaag Rasmussen et al. LANCET NEUROLOGY
- The Meningeal Lymphatic System: A New Player in Neurophysiology
- (2018) Sandro Da Mesquita et al. NEURON
- Blood-Brain Barrier: From Physiology to Disease and Back
- (2018) Melanie D. Sweeney et al. PHYSIOLOGICAL REVIEWS
- Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
- (2018) Humberto Mestre et al. Nature Communications
- Aquaporin-4-dependent glymphatic solute transport in the rodent brain
- (2018) Humberto Mestre et al. eLife
- Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study
- (2018) Yolanda Ohene et al. NEUROIMAGE
- Molecular characterization of perivascular drainage pathways in the murine brain
- (2017) Melanie-Jane Hannocks et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow
- (2017) Beatrice Bedussi et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
- (2017) Antoine Louveau et al. JOURNAL OF CLINICAL INVESTIGATION
- Quantifying the influence of respiration and cardiac pulsations on cerebrospinal fluid dynamics using real-time phase-contrast MRI
- (2017) Selda Yildiz et al. JOURNAL OF MAGNETIC RESONANCE IMAGING
- Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache
- (2017) Aaron J. Schain et al. JOURNAL OF NEUROSCIENCE
- Identification of the Upward Movement of Human CSF In Vivo and its Relation to the Brain Venous System
- (2017) Steffi Dreha-Kulaczewski et al. JOURNAL OF NEUROSCIENCE
- Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery
- (2017) Michelle E. Pizzo et al. JOURNAL OF PHYSIOLOGY-LONDON
- Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T
- (2017) Hedok Lee et al. MAGNETIC RESONANCE IN MEDICINE
- Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow
- (2017) Karl Erik Holter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications
- (2017) Yiming Lei et al. PROGRESS IN NEUROBIOLOGY
- Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
- (2017) Qiaoli Ma et al. Nature Communications
- A Global Approach for Quantitative Super Resolution and Electron Microscopy on Cryo and Epoxy Sections Using Self-labeling Protein Tags
- (2017) Andreas Müller et al. Scientific Reports
- Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma
- (2017) Alex J Smith et al. eLife
- Arterial Pulsations cannot Drive Intramural Periarterial Drainage: Significance for Aβ Drainage
- (2017) Alexandra K. Diem et al. Frontiers in Neuroscience
- Vascular basement membranes as pathways for the passage of fluid into and out of the brain
- (2016) Alan W. J. Morris et al. ACTA NEUROPATHOLOGICA
- Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease
- (2016) Matthew J. Simon et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases
- (2016) Erik N. T. P. Bakker et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- CSF, blood-brain barrier, and brain drug delivery
- (2016) William M. Pardridge Expert Opinion on Drug Delivery
- Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways
- (2016) Beatrice Bedussi et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism
- (2016) Byung-Ju Jin et al. JOURNAL OF GENERAL PHYSIOLOGY
- Glymphatic solute transport does not require bulk flow
- (2016) Mahdi Asgari et al. Scientific Reports
- A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans
- (2015) Reynold Spector et al. EXPERIMENTAL NEUROLOGY
- A balanced view of choroid plexus structure and function: Focus on adult humans
- (2015) Reynold Spector et al. EXPERIMENTAL NEUROLOGY
- Ultra-fast magnetic resonance encephalography of physiological brain activity – Glymphatic pulsation mechanisms?
- (2015) Vesa Kiviniemi et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
- (2015) Aleksanteri Aspelund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Effect of Body Posture on Brain Glymphatic Transport
- (2015) H. Lee et al. JOURNAL OF NEUROSCIENCE
- A novel method to study cerebrospinal fluid dynamics in rats
- (2015) Jason K. Karimy et al. JOURNAL OF NEUROSCIENCE METHODS
- Convection-enhanced delivery to the central nervous system
- (2015) Russell R. Lonser et al. JOURNAL OF NEUROSURGERY
- Implications of the discovery of brain lymphatic pathways
- (2015) Jeffrey J Iliff et al. LANCET NEUROLOGY
- Structural and functional features of central nervous system lymphatic vessels
- (2015) Antoine Louveau et al. NATURE
- Clearance systems in the brain—implications for Alzheimer disease
- (2015) Jenna M. Tarasoff-Conway et al. Nature Reviews Neurology
- White Matter Perivascular Spaces on Magnetic Resonance Imaging
- (2015) Andreas Charidimou et al. STROKE
- Muddying the water in brain edema?
- (2015) Alex J. Smith et al. TRENDS IN NEUROSCIENCES
- How astrocyte networks may contribute to cerebral metabolite clearance
- (2015) Mahdi Asgari et al. Scientific Reports
- Impairment of paravascular clearance pathways in the aging brain
- (2014) Benjamin T. Kress et al. ANNALS OF NEUROLOGY
- Failure of Perivascular Drainage of β-amyloid in Cerebral Amyloid Angiopathy
- (2014) Cheryl A. Hawkes et al. BRAIN PATHOLOGY
- Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury
- (2014) Jeffrey J. Iliff et al. JOURNAL OF NEUROSCIENCE
- Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI
- (2014) Thomas Gaberel et al. STROKE
- Drowning stars: reassessing the role of astrocytes in brain edema
- (2014) Alexander S. Thrane et al. TRENDS IN NEUROSCIENCES
- Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models
- (2013) Michal Arbel-Ornath et al. ACTA NEUROPATHOLOGICA
- Biology of AQP4 and Anti-AQP4 Antibody: Therapeutic Implications for NMO
- (2013) A. S. Verkman et al. BRAIN PATHOLOGY
- Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
- (2013) Jeffrey J. Iliff et al. JOURNAL OF CLINICAL INVESTIGATION
- Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain
- (2013) J. J. Iliff et al. JOURNAL OF NEUROSCIENCE
- Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer
- (2013) Lijun Yang et al. Journal of Translational Medicine
- Physiology of the Intrathecal Bolus: The Leptomeningeal Route for Macromolecule and Particle Delivery to CNS
- (2013) Mikhail I. Papisov et al. MOLECULAR PHARMACEUTICS
- Diffusion of Macromolecules in the Brain: Implications for Drug Delivery
- (2013) Daniel J. Wolak et al. MOLECULAR PHARMACEUTICS
- Aquaporin water channels in the nervous system
- (2013) Marios C. Papadopoulos et al. NATURE REVIEWS NEUROSCIENCE
- Review: Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy
- (2013) R. O. Carare et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Water influx into cerebrospinal fluid is primarily controlled by aquaporin-4, not by aquaporin-1
- (2013) Hironaka Igarashi et al. NEUROREPORT
- Physiological Roles of Aquaporin-4 in Brain
- (2013) Erlend A. Nagelhus et al. PHYSIOLOGICAL REVIEWS
- Garbage Truck of the Brain
- (2013) M. Nedergaard SCIENCE
- Sleep Drives Metabolite Clearance from the Adult Brain
- (2013) L. Xie et al. SCIENCE
- Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain
- (2013) Vinita Rangroo Thrane et al. Scientific Reports
- A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid
- (2012) J. J. Iliff et al. Science Translational Medicine
- Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy
- (2011) Cheryl A. Hawkes et al. ACTA NEUROPATHOLOGICA
- Real-Time Imaging of Perivascular Transport of Nanoparticles During Convection-Enhanced Delivery in the Rat Cortex
- (2011) Conor P. Foley et al. ANNALS OF BIOMEDICAL ENGINEERING
- Fluid mechanics in the perivascular space
- (2011) Peng Wang et al. JOURNAL OF THEORETICAL BIOLOGY
- Cerebrospinal Fluid Flow Dynamics in the Central Nervous System
- (2010) Brian Sweetman et al. ANNALS OF BIOMEDICAL ENGINEERING
- Imaging Brain Activation
- (2010) Gerald A. Dienel et al. Annals of the New York Academy of Sciences
- The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction
- (2010) Thomas Misje Mathiisen et al. GLIA
- Intracisternal enzyme replacement therapy in lysosomal storage diseases: routes of absorption into brain
- (2010) R. D. Jolly et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Trafficking of Glucose, Lactate, and Amyloid-β from the Inferior Colliculus through Perivascular Routes
- (2009) Kelly K Ball et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Lymphatic drainage of the brain and the pathophysiology of neurological disease
- (2008) Roy O. Weller et al. ACTA NEUROPATHOLOGICA
- Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology
- (2008) R. O. Carare et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More