Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain

Cerebrospinal fluid influx drives acute ischemic tissue swelling

(2020) Humberto Mestre et al.   SCIENCE

Re-epithelialization and immune cell behaviour in an ex vivo human skin model

(2020) Ana Rakita et al.   Scientific Reports

The Brain’s Glymphatic System: Current Controversies

(2020) Humberto Mestre et al.   TRENDS IN NEUROSCIENCES

Aris-Taylor dispersion in the subarachnoid space

(2020) Luca Salerno et al.   Physical Review Fluids

Arterial pulsations drive oscillatory flow of CSF but not directional pumping

(2020) Ravi Teja Kedarasetti et al.   Scientific Reports

Varying perivascular astroglial endfoot dimensions along the vascular tree maintain perivascular‐interstitial flux through the cortical mantle

(2020) Marie Xun Wang et al.   GLIA

Respiratory influence on cerebrospinal fluid flow – a computational study based on long-term intracranial pressure measurements

(2019) Vegard Vinje et al.   Scientific Reports

Hydraulic resistance of periarterial spaces in the brain

(2019) Jeffrey Tithof et al.   Fluids and Barriers of the CNS

Dispersion in porous media in oscillatory flow between flat plates: applications to intrathecal, periarterial and paraarterial solute transport in the central nervous system

(2019) M. Keith Sharp et al.   Fluids and Barriers of the CNS

Fluid dynamics of cerebrospinal fluid flow in perivascular spaces

(2019) John H. Thomas   Journal of the Royal Society Interface

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

(2018) N. Joan Abbott et al.   ACTA NEUROPATHOLOGICA

On the bulk motion of the cerebrospinal fluid in the spinal canal

(2018) A. L. Sánchez et al.   JOURNAL OF FLUID MECHANICS

Critical aggregation concentration for the formation of early Amyloid-β (1–42) oligomers

(2018) Mercedes Novo et al.   Scientific Reports

Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain

(2018) Qiaoli Ma et al.   ACTA NEUROPATHOLOGICA

On the dispersion of a drug delivered intrathecally in the spinal canal

(2018) J. J. Lawrence et al.   JOURNAL OF FLUID MECHANICS

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

(2018) Humberto Mestre et al.   Nature Communications

Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow

(2017) Beatrice Bedussi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache

(2017) Aaron J. Schain et al.   JOURNAL OF NEUROSCIENCE

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

(2017) Michelle E. Pizzo et al.   JOURNAL OF PHYSIOLOGY-LONDON

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism

(2016) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

(2016) Thiyagaragan M. Achariyar et al.   Molecular Neurodegeneration

Glymphatic solute transport does not require bulk flow

(2016) Mahdi Asgari et al.   Scientific Reports

CNS wide simulation of flow resistance and drug transport due to spinal microanatomy

(2015) Kevin M. Tangen et al.   JOURNAL OF BIOMECHANICS

Amyloid-β efflux from the central nervous system into the plasma

(2014) Kaleigh Filisa Roberts et al.   ANNALS OF NEUROLOGY

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Fluid mechanics in the perivascular space

(2011) Peng Wang et al.   JOURNAL OF THEORETICAL BIOLOGY