Article
Radiology, Nuclear Medicine & Medical Imaging
Johannes Toger, Mads Andersen, Olle Haglund, Tekla Maria Kylkilahti, Iben Lundgaard, Karin Markenroth Bloch
Summary: In this study, a real-time flow MRI method was developed to quantify respiratory-related variations of cerebrospinal fluid (CSF) flow in the cerebral aqueduct. The method showed good repeatability and a relationship between flow and respiration in both phantom and in vivo experiments.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Biophysics
Robert A. Lloyd, Marcus A. Stoodley, Lynne E. Bilston
Summary: Chiari malformation can be better understood through 3D shape analysis, and the distance between the hindbrain and the inner surfaces of the posterior cranial fossa is related to patient symptoms.
JOURNAL OF BIOMECHANICS
(2022)
Article
Neurosciences
Jun-Hee Kim, Jae-Geun Im, Sung-Hong Park
Summary: Recent studies have proposed a new method for quantifying CSF pulsation, which successfully detected higher CSF flow during the resting state and typical task states. This method also demonstrated dynamic functional changes in CSF pulsation, showing decreased pulsation during activation-on blocks and increased pulsation during activation-off blocks. Additionally, it significantly correlated with stroke volume measured using PC MRI, providing more accurate pulsatility information and faster results compared to conventional methods.
Article
Veterinary Sciences
Carlotta Remelli, Alba Martello, Alessia Valentini, Barbara Contiero, Marco Bernardini
Summary: This study retrospectively investigated the characteristics of cervical spine MRI in dogs diagnosed with SRMA and compared the diagnostic capability of low-field and high-field MRI. The results showed that the most frequent MRI abnormality was meningeal enhancement, often accompanied by enhancement of the synovium of the articular facets and/or muscular enhancement. Both low-field and high-field MRI had good diagnostic capability, with high-field MRI allowing for a more thorough investigation. MRI can be used as a complementary tool to cerebrospinal fluid analysis.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Tommaso Davini, Chiara Mattei, Claudia La Rosa, Carlotta Remelli, Swan Specchi, Elena Lionello, Elena Dell'Era, Marco Bernardini
Summary: This study retrospectively investigated a large population of dogs and cats with porencephaly. The study found that postnatal traumatic events may be a common cause of porencephaly and that there is a high prevalence of seizure activity in porencephalic patients.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Hyunju Cho, Yejin Kim, Saebyel Hong, Hojung Choi
Summary: This study used magnetic resonance imaging to obtain cerebrospinal fluid flow velocity data in healthy beagle dogs, finding bidirectional flow in the subarachnoid space and cerebral aqueduct. A reference dataset of peak velocities of cerebrospinal fluid flow in healthy dogs was successfully obtained.
JOURNAL OF VETERINARY SCIENCE
(2021)
Article
Biophysics
Jun-Hee Kim, Jae-Geun Im, Sung-Hong Park
Summary: This study proposes a new approach to studying the alteration of cerebrospinal fluid (CSF) dynamics in traumatic brain injury (TBI) patients. The findings suggest that the decreased CSF pulsation after TBI could lead to the accumulation of toxic substances in the brain and have an adverse effect on brain function.
NMR IN BIOMEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Jong Uk Kim, Hyejin Park, Jehyung Ok, Juheon Lee, Woojin Jung, Jiwon Kim, Jaehyun Kim, Suhyeon Kim, Yong Ho Kim, Minah Suh, Tae-il Kim
Summary: The study introduced a CSF-philic PDMS window coated with PVA, which effectively reduces bubble trapping, enhances biocompatibility, and maintains long-term optical clarity of cranial windows. Experimental results demonstrate minimal damage to neuronal tissues and attenuated immune response with this window.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Geriatrics & Gerontology
Atef Badji, Joana B. Pereira, Sara Shams, Johan Skoog, Anna Marseglia, Konstantinos Poulakis, Lina Ryden, Kaj Blennow, Henrik Zetterberg, Silke Kern, Anna Zettergren, Lars-Olof Wahlund, Helene Girouard, Ingmar Skoog, Eric Westman
Summary: Good blood pressure control may help prevent cerebrovascular pathology. Hypertension may contribute to cognitive decline through its effect on cerebrovascular pathology rather than AD-related pathology.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Engineering, Chemical
Denis Wypysek, Anna Maria Kalde, Florian Pradellok, Matthias Wessling
Summary: This study uses MRI to analyze the wetting process in multibore membrane-based filtration modules, showing the impact of initial wetting conditions, flux, packing density, and membrane module length on the spatio-temporal evolution of fluid distribution patterns.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Endocrinology & Metabolism
Lusen Ran, Yuqin He, Jiayu Zhu, Fan Long, Yijing Dong, Xiaopeng Song, Wei Wang, Minghuan Wang
Summary: This study proposes an improved MRI method to assess the mobility of cerebrospinal fluid (CSF) in the brain. The method can obtain high-resolution imaging of CSF mobility and distinguish CSF movement across different pulse phases. The results show that older healthy participants and patients with acute ischemic stroke have lower CSF mobility.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Engineering, Biomedical
Shuhei Shibukawa, Tetsu Niwa, Tosiaki Miyati, Tetsuo Ogino, Daisuke Yoshimaru, Kagayaki Kuroda
Summary: In this study, the application of second-order motion compensation diffusion tensor imaging (2nd-MC DTI) with fractional anisotropy (FA) processing was found to reduce the impact of pulsation on CSF temperature measurements, improving the accuracy of intracranial CSF temperature determination.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Clinical Neurology
J. F. Carlsen, A. D. L. Backlund, C. A. Mardal, S. Taudorf, A. Holst, T. N. Munch, A. E. Hansen, S. G. Hasselbalch
Summary: The Normal Pressure Hydrocephalus Radscale shows moderate discrimination for distinguishing idiopathic normal pressure hydrocephalus shunt responders from nonresponders, but cannot be used as the sole criterion for selecting patients for shunt surgery.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Medicine, Research & Experimental
Mohammed S. Alshuhri, Lindsay Gallagher, Lorraine M. Work, William M. Holmes
Summary: The recently proposed glymphatic pathway for solute transport and waste clearance from the brain has been the focus of intense debate. By using an isotopically enriched MRI tracer, researchers directly imaged glymphatic water transport in the rat brain in vivo, revealing faster and more extensive transport than previously thought, with aquaporin-4 channels playing a critical role.
Article
Biochemistry & Molecular Biology
Francesco Errico, Carmen Marino, Manuela Grimaldi, Tommaso Nuzzo, Valentina Bassareo, Valeria Valsecchi, Chiara Panicucci, Elia Di Schiavi, Tommaso Mazza, Claudio Bruno, Adele D'Amico, Manolo Carta, Anna Maria D'Ursi, Enrico Bertini, Livio Pellizzoni, Alessandro Usiello
Summary: In this study, the metabolic effects of Nusinersen in the cerebrospinal fluid (CSF) of spinal muscular atrophy (SMA) patients were characterized using nuclear magnetic resonance (NMR) spectroscopy. The results showed that Nusinersen can modulate amino acid metabolism with distinct downstream metabolic effects according to disease severity. These findings suggest that Nusinersen selectively modulates peripheral organ metabolism in severe SMA patients.
Article
Otorhinolaryngology
G. Michael Halmagyi, Geoffrey D. Parker, Luke Chen, Miriam S. Welgampola, John D. G. Watson, Michael H. Barnett, Michael J. Todd, Shadi El-Wahsh, Victoria Rose, Marcus A. Stoodley, Jeffrey W. Brennan
Summary: Superficial siderosis, a progressive neurological disease, can cause bilateral impairment of auditory and vestibular function. This study found that the disease is often due to a repairable spinal dural defect. The patients in the study had progressive bilateral sensorineural hearing loss and vestibular loss, and surgical repair did not lead to improvement.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Editorial Material
Neurosciences
Lorelei D. Shoemaker, Richard Daneman, Marcus A. Stoodley
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Nivedita Agarwal, Laura D. Lewis, Lydiane Hirschler, Leonardo Rivera Rivera, Shinji Naganawa, Swati Rane Levendovszky, Geir Ringstad, Marijan Klarica, Joanna Wardlaw, Costantino Iadecola, Cheryl Hawkes, Roxana Octavia Carare, Jack Wells, Erik N. T. P. Bakker, Vartan Kurtcuoglu, Lynne Bilston, Maiken Nedergaard, Yuki Mori, Marcus Stoodley, Noam Alperin, Mony de Leon, Matthias J. P. van Osch
Summary: Neurofluids refer to all fluids in the brain and spine, including blood, cerebrospinal fluid, and interstitial fluid. Neuroscientists have identified various fluid environments that interact harmoniously to support optimal brain function. Animal studies have been crucial in understanding the dynamics of neurofluids, while human studies are limited due to the lack of noninvasive imaging techniques. The future development of noninvasive MRI techniques holds promise in imaging neurofluid dynamics and identifying pathological processes.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Multidisciplinary Sciences
Joel A. Berliner, Magdalena A. Lam, Elmira Najafi, Sarah J. Hemley, Lynne E. Bilston, Marcus A. Stoodley
Summary: This study investigated the expression of Aquaporin-4 (AQP4) in post-traumatic syringomyelia (PTS) and its effect on syrinx size. The results showed that increased AQP4 expression was associated with larger cysts, but there were no localized changes in specific regions. Modulation of AQP4 did not alter syrinx volume and length. Further research should focus on earlier time-points after PTS induction to investigate the potential effects of AQP4 modulation.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Jesse L. Parker, Andrew Vakulin, Yohannes Adama Melaku, Gary A. Wittert, Sean A. Martin, Angela L. D'Rozario, Peter G. Catcheside, Bastien Lechat, Barbara Toson, Alison J. Teare, Sarah L. Appleton, Robert J. Adams
Summary: This study examined the association between sleep microarchitecture and cognitive function in community-dwelling men over an 8-year follow-up. The results showed no independent association between sleep microarchitecture and cognitive function.
NATURE AND SCIENCE OF SLEEP
(2023)
Correction
Clinical Neurology
Jesse L. Parker, Andrew Vakulin, Yohannes Adama Melaku, Gary A. Wittert, Sean A. Martin, Angela L. D'Rozario, Peter G. Catcheside, Bastien Lechat, Barbara Toson, Alison J. Teare, Sarah L. Appleton, Robert J. Adams
NATURE AND SCIENCE OF SLEEP
(2023)
Article
Clinical Neurology
Jesse L. Parker, Sarah L. Appleton, Robert J. Adams, Yohannes Adama Melaku, Angela L. D'Rozario, Gary A. Wittert, Sean A. Martin, Peter G. Catcheside, Bastien Lechat, Alison J. Teare, Barbara Toson, Andrew Vakulin
Summary: This study found associations between sleep spindles and cognitive function, with obstructive sleep apnea severity moderating these associations. It highlights the potential utility of sleep spindles as cognitive function markers in obstructive sleep apnea, warranting further longitudinal investigation.
Article
Emergency Medicine
James Evenden, Daniel Harris, Adam J. Wells, Barbara Toson, Daniel Y. Ellis, Paul F. Lambert
Summary: This study aimed to evaluate the impact of distance and time to a major trauma center on patient outcomes in traumatic brain injury cases. The findings suggest that increasing distance or time from the injury site to a trauma center does not significantly affect patient outcomes.
EMERGENCY MEDICINE AUSTRALASIA
(2023)
Article
Geriatrics & Gerontology
Laura C. Edney, Hossein Haji Ali Afzali, Renuka Visvanathan, Barbara Toson, Jonathan Karnon
Summary: This study examines the impact of delayed home care package access on healthcare costs for older adults. The results suggest that healthcare costs increase after receiving a home care package, particularly in terms of inpatient care.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Clinical Neurology
Jesse L. Parker, Andrew Vakulin, Ganesh Naik, Yohannes Adama Melaku, David Stevens, Gary A. Wittert, Sean A. Martin, Peter G. Catcheside, Barbara Toson, Sarah L. Appleton, Robert J. Adams
Summary: This study examined the impact of obstructive sleep apnea and sleep macroarchitecture on future cognitive function. The results showed that a higher percentage of light sleep was associated with better cognitive performance, while higher mean oxygen saturation was associated with worse performance.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Engineering, Biomedical
Alice Hatt, Robert Lloyd, Bart Bolsterlee, Lynne E. Bilston
Summary: Human adipose tissue deforms significantly under physiological loading and impact, making accurate data on strain-dependent stiffness of fat essential for biomechanical models. Using magnetic resonance elastography, the shear modulus of fat was quantified in vivo and found to increase exponentially with compressive strain. This information can be used to develop realistic computational models for impact, injury, and biomechanics.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Clinical Neurology
Fiona L. Knapman, E. Myfanwy Cohen, Tom Kulaga, Nigel Lovell, Leszek Lisowski, Simon Mcmullan, Peter G. R. Burke, Lynne E. Bilston
Summary: This study proposes a novel optogenetics-based therapy for obstructive sleep apnea (OSA) and demonstrates its feasibility using a rodent model. The therapy involves stimulating upper airway muscle contractions in response to light. The results show that muscle-specific promoter-driven optogenetic muscle activation can effectively restore muscle activity and induce airway dilation.
Article
Public, Environmental & Occupational Health
Julie Brown, Bianca Albanese, Catherine Ho, Jane Elkington, Sjaan Koppel, Judith L. Charlton, Jake Olivier, Lisa Keay, Lynne E. Bilston
Summary: This study compared characteristics and restraint use between a population-based sample and a fitting service sample of child restraint users. The results showed significant differences in restraint types, age, and gender between the two samples. Overall, the population-based sample had more errors in restraint use. However, after controlling for restraint type, securing errors and serious installation errors were more common in the fitting service sample.
TRAFFIC INJURY PREVENTION
(2023)
Correction
Physiology
B. L. Luu, R. H. C. Lewis, S. C. Gandevia, C. L. Boswell-Ruys, J. E. Butler
Summary: This study examined the sensations of breathing after tetraplegia. The findings showed that individuals with chronic tetraplegia had a higher detection threshold for added resistance during inspiration compared to able-bodied controls. However, both groups perceived larger loads as more effortful, with perception related to maximal inspiratory muscle force rather than absolute force.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)