CrossTalk opposing view: Going against the flow: interstitial solute transport in brain is diffusive and aquaporin‐4 independent

Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression

(2019) Brana Rosic et al.   GLIA

Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

(2018) Nazira J. Albargothy et al.   ACTA NEUROPATHOLOGICA

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

(2018) N. Joan Abbott et al.   ACTA NEUROPATHOLOGICA

The “glymphatic” mechanism for solute clearance in Alzheimer’s disease: game changer or unproven speculation?

(2018) Alex J. Smith et al.   FASEB JOURNAL

Voluntary running enhances glymphatic influx in awake behaving, young mice

(2018) Stephanie von Holstein-Rathlou et al.   NEUROSCIENCE LETTERS

Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function

(2018) Iben Lundgaard et al.   Scientific Reports

General Anesthesia Inhibits the Activity of the “Glymphatic System”

(2018) Clement Gakuba et al.   Theranostics

Contributions of the glycocalyx, endothelium, and extravascular compartment to the blood–brain barrier

(2018) Nikolay Kutuzov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain

(2018) Qiaoli Ma et al.   ACTA NEUROPATHOLOGICA

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

(2018) Humberto Mestre et al.   eLife

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

(2017) Michelle E. Pizzo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T

(2017) Hedok Lee et al.   MAGNETIC RESONANCE IN MEDICINE

Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow

(2017) Karl Erik Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

(2017) Alex J Smith et al.   eLife

Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism

(2016) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans

(2015) Reynold Spector et al.   EXPERIMENTAL NEUROLOGY

How astrocyte networks may contribute to cerebral metabolite clearance

(2015) Mahdi Asgari et al.   Scientific Reports

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Aquaporin water channels in the nervous system

(2013) Marios C. Papadopoulos et al.   NATURE REVIEWS NEUROSCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Diffusion Properties of Molecules at the Blood-Brain Interface: Potential Contributions of Astrocyte Endfeet to Diffusion Barrier Functions

(2012) M. Nuriya et al.   CEREBRAL CORTEX

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Aquaporin-4-Deficient Mice Have Increased Extracellular Space without Tortuosity Change

(2008) X. Yao et al.   JOURNAL OF NEUROSCIENCE

Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex

(2008) K. Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA