The Effects of Nuclear Factor Erythroid 2 (NFE2)-Related Factor 2 (Nrf2) Activation in Preclinical Models of Peripheral Neuropathic Pain

Preconditioning by voluntary wheel running attenuates later neuropathic pain via Nrf2 antioxidant signaling in rats

(2022) Suzanne M. Green-Fulgham et al.   PAIN

7β-(3-Ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z Notonipetranone Attenuates Neuropathic Pain by Suppressing Oxidative Stress, Inflammatory and Pro-Apoptotic Protein Expressions

(2021) Amna Khan et al.   MOLECULES

Carvacrol abates NLRP3 inflammasome activation by augmenting Keap1/Nrf-2/p62 directed autophagy and mitochondrial quality control in neuropathic pain

(2021) Vijay Kumar Arruri et al.   NUTRITIONAL NEUROSCIENCE

Anti-inflammatory effect of resveratrol attenuates the severity of diabetic neuropathy by activating the Nrf2 pathway

(2021) Wanli Zhang et al.   Aging-US

Combination of autophagy and NFE2L2/NRF2 activation as a treatment approach for neuropathic pain

(2021) Jian Li et al.   Autophagy

PEA-OXA Mitigates Oxaliplatin-Induced Painful Neuropathy through NF-κB/Nrf-2 Axis

(2021) Michela Campolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sirt2 in the Spinal Cord Regulates Chronic Neuropathic Pain Through Nrf2-Mediated Oxidative Stress Pathway in Rats

(2021) Mengnan Zhao et al.   Frontiers in Pharmacology

Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response

(2021) Benedetta Parodi et al.   Frontiers in Immunology

Dexmedetomidine alleviates inflammation in neuropathic pain by suppressing NLRP3 via Nrf2 activation

(2021) Wenyan Shan et al.   Experimental and Therapeutic Medicine

Dexmedetomidine Relieves Neuropathic Pain in Rats With Chronic Constriction Injury via the Keap1–Nrf2 Pathway

(2021) Yatao Liu et al.   Frontiers in Cell and Developmental Biology

Nrf2 Activation Attenuates Chronic Constriction Injury-Induced Neuropathic Pain via Induction of PGC-1α-Mediated Mitochondrial Biogenesis in the Spinal Cord

(2021) Jia Sun et al.   Oxidative Medicine and Cellular Longevity

Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain

(2020) Ya-qun Zhou et al.   ACTA PHARMACOLOGICA SINICA

Mitoquinone alleviates vincristine-induced neuropathic pain through inhibiting oxidative stress and apoptosis via the improvement of mitochondrial dysfunction

(2020) Xue-Jun Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

SIRT1 Activation by Polydatin Alleviates Oxidative Damage and Elevates Mitochondrial Biogenesis in Experimental Diabetic Neuropathy

(2020) Preethi Bheereddy et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Bergenin Reduces Experimental Painful Diabetic Neuropathy by Restoring Redox and Immune Homeostasis in the Nervous System

(2020) Cristiane F. Villarreal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bardoxolone Methyl Ameliorates Hyperglycemia Induced Mitochondrial Dysfunction by Activating the keap1-Nrf2-ARE Pathway in Experimental Diabetic Neuropathy

(2020) Anil Kumar Kalvala et al.   MOLECULAR NEUROBIOLOGY

Oltipraz Prevents High Glucose-Induced Oxidative Stress and Apoptosis in RSC96 Cells through the Nrf2/NQO1 Signalling Pathway

(2020) Zengxin Jiang et al.   Biomed Research International

Paeoniflorin attenuates chronic constriction injury-induced neuropathic pain by suppressing spinal NLRP3 inflammasome activation

(2020) Pei Liu et al.   INFLAMMOPHARMACOLOGY

Formononetin ameliorates oxaliplatin-induced peripheral neuropathy via the KEAP1-NRF2-GSTP1 axis

(2020) Yuan Fang et al.   Redox Biology

Safety and Efficacy of Omaveloxolone in Friedreich's Ataxia ( MOXIe Study)

(2020) David R. Lynch et al.   ANNALS OF NEUROLOGY

PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway

(2020) Ya-Qun Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

Treatment with 5-fluoro-2-oxindole Increases the Antinociceptive Effects of Morphine and Inhibits Neuropathic Pain

(2020) Pablo Ferreira-Chamorro et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands

(2020) Sisca Meida Wati et al.   Redox Biology

Diphenyl diselenide alleviates diabetic peripheral neuropathy in rats with streptozotocin-induced diabetes by modulating oxidative stress

(2020) Xing Wang et al.   BIOCHEMICAL PHARMACOLOGY

Resveratrol exerts anti-oxidant and anti-inflammatory actions and prevents oxaliplatin-induced mechanical and thermal allodynia

(2020) M.D. Recalde et al.   BRAIN RESEARCH

Protective Effects of Curcumin Against Paclitaxel-Induced Spinal Cord and Sciatic Nerve Injuries in Rats

(2020) Ahmet Yardım et al.   NEUROCHEMICAL RESEARCH

Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-κB, ATF-6 pathways and activating Nrf2, Akt pathways

(2020) Ahmet Yardim et al.   NEUROTOXICOLOGY

Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats

(2020) Samar Rezq et al.   Scientific Reports

Chemotherapy-Induced Peripheral Neuropathy

(2019) Timothy J Brown et al.   JAMA Oncology

Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated

(2019) Sara Polo et al.   Frontiers in Pharmacology

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

(2019) Andrea Rodrigues Vasconcelos et al.   Frontiers in Pharmacology

Alphalipoic Acid Prevents Oxidative Stress and Peripheral Neuropathy in Nab-Paclitaxel-Treated Rats through the Nrf2 Signalling Pathway

(2019) Hong Sun et al.   Oxidative Medicine and Cellular Longevity

Why the sexes don’t feel pain the same way

(2019) Amber Dance   NATURE

Mechanisms of Chemotherapy-Induced Peripheral Neuropathy

(2019) Renata Zajączkowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Engagement of MicroRNA-155 in Exaggerated Oxidative Stress Signal and TRPA1 in the Dorsal Horn of the Spinal Cord and Neuropathic Pain During Chemotherapeutic Oxaliplatin

(2019) Fenghua Miao et al.   NEUROTOXICITY RESEARCH

Analgesic and Antidepressant Effects of Oltipraz on Neuropathic Pain in Mice by Modulating Microglial Activation

(2019) Andrés Felipe Díaz et al.   Journal of Clinical Medicine

Nrf2/HO-1 signaling pathway participated in the protection of hydrogen sulfide on neuropathic pain in rats

(2019) Hongguang Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Levo-corydalmine Attenuates Vincristine-Induced Neuropathic Pain in Mice by Upregulating the Nrf2/HO-1/CO Pathway to Inhibit Connexin 43 Expression

(2019) Lin Zhou et al.   Neurotherapeutics

Isoquercitrin promotes peripheral nerve regeneration through inhibiting oxidative stress following sciatic crush injury in mice

(2019) Jiaying Qiu et al.   Annals of Translational Medicine

Oral Dimethyl Fumarate Reduces Peripheral Neuropathic Pain in Rodents via NFE2L2 Antioxidant Signaling

(2019) Jiahe Li et al.   ANESTHESIOLOGY

The Role of Sirtuins in Antioxidant and Redox Signaling

(2018) Chandra K. Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain

(2018) Gabriela Riego et al.   BIOCHEMICAL PHARMACOLOGY

Expression of Nrf2 Promotes Schwann Cell-Mediated Sciatic Nerve Recovery in Diabetic Peripheral Neuropathy

(2018) Wei Tang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Nrf2 inhibits oxaliplatin-induced peripheral neuropathy via protection of mitochondrial function

(2018) Yang Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Crosstalk between Nrf2 and Inflammasomes

(2018) Paulina Hennig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dimethyl fumarate ameliorates chemotherapy agent-induced neurotoxicity in vitro

(2018) Takehiro Kawashiri et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neuroprotective effect of tanshinone IIA against neuropathic pain in diabetic rats through the Nrf2/ARE and NF-κB signaling pathways

(2018) Fa-Bo Feng et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Local low dose curcumin treatment improves functional recovery and remyelination in a rat model of sciatic nerve crush through inhibition of oxidative stress

(2018) Martial Caillaud et al.   NEUROPHARMACOLOGY

Schwann Cell Plasticity is Regulated by a Weakened Intrinsic Antioxidant Defense System in Acute Peripheral Nerve Injury

(2018) Wenjing Lv et al.   NEUROSCIENCE

The Natural Rotenoid Deguelin Ameliorates Diabetic Neuropathy by Decreasing Oxidative Stress and Plasma Glucose Levels in Rats via the Nrf2 Signalling Pathway

(2018) Ji Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain

(2018) Serena Boccella et al.   FASEB JOURNAL

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

(2018) Anna Picca et al.   Nature Reviews Cardiology

Role of Keap1-Nrf2 Signaling in Anhedonia Symptoms in a Rat Model of Chronic Neuropathic Pain: Improvement With Sulforaphane

(2018) Shan Li et al.   Frontiers in Pharmacology

Study of nuclear factor‐2 erythroid related factor‐2 activator, berberine, in paclitaxel induced peripheral neuropathy pain model in rats

(2018) Jagjit Singh et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Naringenin targets on astroglial Nrf2 to support dopaminergic neurons

(2018) Guo-Qing Wang et al.   PHARMACOLOGICAL RESEARCH

Sulforaphane Inhibited the Nociceptive Responses, Anxiety- and Depressive-Like Behaviors Associated With Neuropathic Pain and Improved the Anti-allodynic Effects of Morphine in Mice

(2018) Pablo Ferreira-Chamorro et al.   Frontiers in Pharmacology

L-Carnosine protects against Oxaliplatin-induced peripheral neuropathy in colorectal cancer patients: A perspective on targeting Nrf-2 and NF-κB pathways

(2018) Rana Yehia et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular mesangial cells

(2017) Kaipeng Huang et al.   EXPERIMENTAL CELL RESEARCH

Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys

(2017) Wenyan Gong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy

(2017) Veera Ganesh Yerra et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Combination strategy of PARP inhibitor with antioxidant prevent bioenergetic deficits and inflammatory changes in CCI-induced neuropathy

(2017) Prashanth Komirishetty et al.   NEUROPHARMACOLOGY

Nrf2 and NF-κB modulation by Plumbagin attenuates functional, behavioural and biochemical deficits in rat model of neuropathic pain

(2017) Vijay Arruri et al.   Pharmacological Reports

The induction of the transcription factor Nrf2 enhances the antinociceptive effects of delta-opioid receptors in diabetic mice

(2017) Christina McDonnell et al.   PLoS One

Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice

(2017) Francesco De Logu et al.   Nature Communications

Anti-nociceptive and anti-inflammatory actions of sulforaphane in chronic constriction injury-induced neuropathic pain mice

(2017) Cheng Wang et al.   INFLAMMOPHARMACOLOGY

Ameliorative potential of rutin in combination with nimesulide in STZ model of diabetic neuropathy: targeting Nrf2/HO-1/NF-kB and COX signalling pathway

(2017) Ruchika Mittal et al.   INFLAMMOPHARMACOLOGY

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

(2017) Marta Pajares et al.   Redox Biology

Tangluoning, a traditional Chinese medicine, attenuates in vivo and in vitro diabetic peripheral neuropathy through modulation of PERK/Nrf2 pathway

(2017) Xinwei Yang et al.   Scientific Reports

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

(2016) Marta Pajares et al.   Autophagy

Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane

(2016) J. E. Bauman et al.   Cancer Prevention Research

Attenuation of neuropathic pain and neuroinflammatory responses by a pyranocoumarin derivative, anomalin in animal and cellular models

(2016) Salman Khan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats

(2016) Ruifeng Tian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Paeoniflorin protects Schwann cells against high glucose induced oxidative injury by activating Nrf2/ARE pathway and inhibiting apoptosis

(2016) Xinwei Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Sex Differences in Pain

(2016) Robert E. Sorge et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Sex differences in neuroimmunity and pain

(2016) Sarah Rosen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Sesame oil improves functional recovery by attenuating nerve oxidative stress in a mouse model of acute peripheral nerve injury: role of Nrf-2

(2016) Che-Chia Hsu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Modulation of the antioxidant nuclear factor (erythroid 2-derived)-like 2 pathway by antidepressants in rats

(2016) David Martín-Hernández et al.   NEUROPHARMACOLOGY

Naringenin reduces inflammatory pain in mice

(2016) Felipe A. Pinho-Ribeiro et al.   NEUROPHARMACOLOGY

Chemotherapy-induced neuropathies-a growing problem for patients and health care providers

(2016) Marta Banach et al.   Brain and Behavior

Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS

(2015) Benedetta Parodi et al.   ACTA NEUROPATHOLOGICA

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Fisetin Imparts Neuroprotection in Experimental Diabetic Neuropathy by Modulating Nrf2 and NF-κB Pathways

(2015) Reddemma Sandireddy et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Chemotherapy-induced peripheral neuropathy: What do we know about mechanisms?

(2015) V.A. Carozzi et al.   NEUROSCIENCE LETTERS

Inhaled hydrogen sulfide prevents neuropathic pain after peripheral nerve injury in mice

(2015) Kotaro Kida et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Redox control of protein degradation

(2015) Marta Pajares et al.   Redox Biology

Taurine ameliorates neuropathy via regulating NF-κB and Nrf2/HO-1 signaling cascades in diabetic rats

(2014) Can Ali Agca et al.   FOOD AND CHEMICAL TOXICOLOGY

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE

(2014) Hui Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline

(2014) Dawn L. Hershman et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular Hydrogen Attenuates Neuropathic Pain in Mice

(2014) Masanori Kawaguchi et al.   PLoS One

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Are Reactive Oxygen Species Always Detrimental to Pathogens?

(2013) Claudia N. Paiva et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

The Bioactivity and Toxicological Actions of Carvacrol

(2013) Zacharias E. Suntres et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

Deletion of Nrf2 impairs functional recovery, reduces clearance of myelin debris and decreases axonal remyelination after peripheral nerve injury

(2013) Linxia Zhang et al.   NEUROBIOLOGY OF DISEASE

Neuropathic pain in the general population: A systematic review of epidemiological studies

(2013) O. van Hecke et al.   PAIN

Oxaliplatin-induced peripheral neuropathy’s effects on health-related quality of life of colorectal cancer survivors

(2013) Cindy Tofthagen et al.   SUPPORTIVE CARE IN CANCER

Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy

(2013) Veera Ganesh Yerra et al.   Redox Biology

Epidemiology of Neuropathic Pain and Its Impact on Quality of Life

(2012) Blair H. Smith et al.   Current Pain and Headache Reports

TRPM2 Contributes to Inflammatory and Neuropathic Pain through the Aggravation of Pronociceptive Inflammatory Responses in Mice

(2012) K. Haraguchi et al.   JOURNAL OF NEUROSCIENCE

Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed

(2012) Rui Wang   PHYSIOLOGICAL REVIEWS

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

(2011) Miao Yu et al.   CELLULAR SIGNALLING

Extraction of bromelain from pineapple peels

(2011) S. Ketnawa et al.   FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL

Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1

(2011) Julie V Berger et al.   Journal of Neuroinflammation

Mitochondrial abnormality in sensory, but not motor, axons in paclitaxel-evoked painful peripheral neuropathy in the rat

(2011) W.H. Xiao et al.   NEUROSCIENCE

Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel

(2011) W.H. Xiao et al.   NEUROSCIENCE

A new definition of neuropathic pain

(2011) Troels S. Jensen et al.   PAIN

Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-κB and Nrf2 cascades

(2010) Geeta Negi et al.   JOURNAL OF PINEAL RESEARCH

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

(2010) T. Ogura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver

(2010) Curtis D. Klaassen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

(2008) Wenge Li et al.   BIOCHEMICAL PHARMACOLOGY

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Antioxidant Response as a Drug Target in Diabetic Neuropathy

(2008) Andrea Vincent et al.   CURRENT DRUG TARGETS

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

(2008) Yvonne M.W. Janssen-Heininger et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2

(2007) Dianne M. Walters et al.   ANTIOXIDANTS & REDOX SIGNALING