Sex differences in neuroimmunity and pain

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

(2016) Sarah Taves et al.   BRAIN BEHAVIOR AND IMMUNITY

Heterogeneous astrocytes: Active players in CNS

(2016) Xin Hu et al.   BRAIN RESEARCH BULLETIN

17beta-estradiol counteracts neuropathic pain: a behavioural, immunohistochemical and proteomic investigation on sex-related differences in mice

(2016) Valentina Vacca et al.   Scientific Reports

Estrogen receptors regulate innate immune cells and signaling pathways

(2015) Susan Kovats   CELLULAR IMMUNOLOGY

Delayed Activation of Spinal Microglia Contributes to the Maintenance of Bone Cancer Pain in Female Wistar Rats via P2X7 Receptor and IL-18

(2015) Y. Yang et al.   JOURNAL OF NEUROSCIENCE

Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade

(2015) Zhen-Zhong Xu et al.   NATURE MEDICINE

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

The therapeutic potential of interleukin-10 in neuroimmune diseases

(2015) A.J. Kwilasz et al.   NEUROPHARMACOLOGY

Opinion: Sex inclusion in basic research drives discovery: Fig. 1.

(2015) Sabra L. Klein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neuroanatomy of sexual dimorphism in opioid analgesia

(2014) Dayna R. Loyd et al.   EXPERIMENTAL NEUROLOGY

Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1

(2014) Chul-Kyu Park et al.   NEURON

XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis

(2014) S. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex differences and hormonal modulation of deep tissue pain

(2013) Richard J. Traub et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Estrogenic influences in pain processing

(2013) Åsa Amandusson et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons

(2013) O. E. Tasdemir-Yilmaz et al.   GENES & DEVELOPMENT

Glia and pain: Is chronic pain a gliopathy?

(2013) Ru-Rong Ji et al.   PAIN

Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury

(2012) Michael J. Chen et al.   GLIA

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

(2012) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Progesterone down-regulates spinal cord inflammatory mediators and increases myelination in experimental autoimmune encephalomyelitis

(2012) L.I. Garay et al.   NEUROSCIENCE

Regulatory T cells attenuate neuropathic pain following peripheral nerve injury and experimental autoimmune neuritis

(2012) Paul J. Austin et al.   PAIN

Peroxisome proliferator-activated receptor (PPAR)  and -  regulate IFN  and IL-17A production by human T cells in a sex-specific way

(2012) M. A. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-chromosome-located microRNAs in immunity: Might they explain male/female differences?

(2011) Iris Pinheiro et al.   BIOESSAYS

Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice

(2011) R. S. Scotland et al.   BLOOD

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

(2011) Makoto Tsuda et al.   BRAIN

Progesterone attenuates astro- and microgliosis and enhances oligodendrocyte differentiation following spinal cord injury

(2011) Florencia Labombarda et al.   EXPERIMENTAL NEUROLOGY

Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus

(2011) Faith M. Strickland et al.   JOURNAL OF AUTOIMMUNITY

Glatiramer acetate attenuates neuropathic allodynia through modulation of adaptive immune cells

(2011) Tanya Leger et al.   JOURNAL OF NEUROIMMUNOLOGY

Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

(2011) R. E. Sorge et al.   JOURNAL OF NEUROSCIENCE

A systematic literature review of 10 years of research on sex/gender and experimental pain perception – Part 1: Are there really differences between women and men?

(2011) Mélanie Racine et al.   PAIN

Effects of testosterone, estrogen and progesterone on TNF-α mediated cellular damage in rat arthritic synovial fibroblasts

(2011) Kalaivani Ganesan et al.   RHEUMATOLOGY INTERNATIONAL

Sex differences in the inflammatory response of primary astrocytes to lipopolysaccharide

(2011) María Santos-Galindo et al.   Biology of Sex Differences

17 -Estradiol Promotes TLR4-Triggered Proinflammatory Mediator Production through Direct Estrogen Receptor   Signaling in Macrophages In Vivo

(2010) B. Calippe et al.   JOURNAL OF IMMUNOLOGY

The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

(2010) Paul J. Austin et al.   JOURNAL OF NEUROIMMUNOLOGY

IL-10 production by CD4+ effector T cells: a mechanism for self-regulation

(2010) D Jankovic et al.   Mucosal Immunology

Estrogen or Estrogen Receptor Agonist Inhibits Lipopolysaccharide Induced Microglial Activation and Death

(2010) Joshua A. Smith et al.   NEUROCHEMICAL RESEARCH

Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies

(2010) Marieke Niesters et al.   PAIN

Sex-specific Mediation of Opioid-induced Hyperalgesia by the Melanocortin-1 Receptor

(2009) Aaron Juni et al.   ANESTHESIOLOGY

Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-γ-inducible protein-10 by astrocytes exposed to inflammatory challengein vitro

(2009) M. Cerciat et al.   GLIA

T-Cell Infiltration and Signaling in the Adult Dorsal Spinal Cord Is a Major Contributor to Neuropathic Pain-Like Hypersensitivity

(2009) M. Costigan et al.   JOURNAL OF NEUROSCIENCE

JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

(2009) Y.-J. Gao et al.   JOURNAL OF NEUROSCIENCE

Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

(2009) Roger B. Fillingim et al.   JOURNAL OF PAIN

CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain

(2008) Ling Cao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia

(2008) Emanuele Cacci et al.   GLIA

THIS ARTICLE HAS BEEN RETRACTED: Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury

(2008) Koichi Obata et al.   JOURNAL OF NEUROCHEMISTRY

Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats

(2008) Danielle K. Lewis et al.   JOURNAL OF NEUROIMMUNOLOGY

Supraspinal Glial-Neuronal Interactions Contribute to Descending Pain Facilitation

(2008) F. Wei et al.   JOURNAL OF NEUROSCIENCE

Up-Regulation of P2X4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

(2008) L. Ulmann et al.   JOURNAL OF NEUROSCIENCE

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

(2008) Yasuhiko Kawasaki et al.   NATURE MEDICINE

Microglial activation and TNF  production mediate altered CNS excitability following peripheral inflammation

(2008) K. Riazi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Testosterone Reduces Macrophage Expression in the Mouse of Toll-Like Receptor 4, a Trigger for Inflammation and Innate Immunity

(2007) Jennifer A. Rettew et al.   BIOLOGY OF REPRODUCTION