Article
Environmental Sciences
Ting Li, Zhou Li, Jianfei Fu, Chunlan Tang, Liya Liu, Jin Xu, Jinshun Zhao, Zhen Li
Summary: This study investigated the cytotoxicity of nickel nanoparticles on HTR-8/SVneo cells in vitro. The results showed that nickel nanoparticles treatment reduced cell viability, increased oxidative stress, and impaired mitochondrial respiratory capacity. Additionally, it induced cell cycle arrest and apoptosis.
ENVIRONMENTAL RESEARCH
(2022)
Article
Cell Biology
Wei-Lun Hsu, Chieh-Min Wang, Chao-Ling Yao, Ssu-Ching Chen, Chung-Yi Nien, Yang-Ho Sun, Tsung-Yu Tseng, Yueh-Hsia Luo
Summary: The selenocompound SeC selectively attacks Nrf2-addicted colorectal cancer cells by reducing Nrf2 and autophagy pathway protein expression, resulting in cell death.
CELL DEATH & DISEASE
(2022)
Article
Cell & Tissue Engineering
Yanting Sun, Hao Xu, Bin Tan, Qin Yi, Huiwen Liu, Tangtian Chen, Han Xiang, Rui Wang, Qiumin Xie, Jie Tian, Jing Zhu
Summary: This study aimed to illustrate the protective effect of andrographolide (AG) against glucose and serum deprivation under hypoxia (GSDH)-induced cell injury in BMSCs and investigate the possible underlying mechanisms. The results showed that AG can protect BMSCs from GSDH-induced cell injury by increasing cell viability and proliferation, enhancing mitochondrial function, and reducing apoptosis and oxidative stress.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Zhiyin Wang, Bin Cai, Chenrui Cao, Haining Lv, Yimin Dai, Mingming Zheng, Guangfeng Zhao, Yanfang Peng, Wenjing Gou, Jingmei Wang, Dan Liu, Yali Hu
Summary: The study demonstrated that CD151 is a key regulator of antioxidants in the placenta, and its expression levels are negatively correlated with the expression of antioxidant genes in PE patients. CD151 may be a new target for PE treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Food Science & Technology
Rong Yan, Hanli Wang, Jiangning Zhu, Tiancheng Wang, Eugenie Nepovimova, Miao Long, Peng Li, Kamil Kuca, Wenda Wu
Summary: This study assessed the effects of procyanidins (PC) on cell apoptosis caused by zearalenone (ZEA) and validated the role of Nrf2 in this process. The findings demonstrated that PC could enhance the cell antioxidant capacity, mitigate ZEA-induced cell apoptosis, and promote the expression of Nrf2 and its downstream genes. This discovery contributes to the clinical application of PC in preventing reproductive toxicity caused by ZEA.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ye Zhao, Qin Jiang, Xuefei Zhang, Xiaoxiao Zhu, Xia Dong, Linyuan Shen, Shunhua Zhang, Lili Niu, Lei Chen, Ming Zhang, Jun Jiang, Daiwen Chen, Li Zhu
Summary: l-Arginine has been shown to reduce muscle injury by regulating the SIRT1-Akt-Nrf2 and SIRT1-FOXO3a-mitochondria apoptosis signaling pathways as a potential nutraceutical.
Article
Biochemistry & Molecular Biology
Menghao Guo, Wenli Zhang, Shuyan Niu, Mengting Shang, Xiaoru Chang, Tianshu Wu, Ting Zhang, Meng Tang, Yuying Xue
Summary: Silver nanoparticles (AgNPs) are widely used for their antibacterial properties, but their use raises health concerns. This study evaluated the toxic effects of AgNPs on liver cells and found that the human hepatoma cell line (HepG2) was more sensitive to AgNPs than normal hepatic cell line (L02), possibly due to different responses to AgNPs by cancer cells and normal cells. N-acetylcysteine (NAC) was able to inhibit the increase in apoptosis induced by AgNPs and alleviate the imbalance of antioxidant system and cell cycle arrest. The knockdown of nuclear factor erythroid-derived factor 2-related factor (Nrf2) showed that Nrf2 has a protective role in AgNPs-induced hepatotoxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Bani Ismail, Peramaiyan Rajendran, Hamad Mohammed AbuZahra, Vishnu Priya Veeraraghavan
Summary: The study evaluated the effects of Mangiferin on DOX-induced cytotoxicity in HUVECs and found that MGN significantly increased Nrf2 expression through upregulating the PI3K/AKT pathway, thereby reducing cell apoptosis induced by DOX.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ru-lan Zhang, Bing-xi Lei, Guo-yong Wu, Yuan-yuan Wang, Qi-hui Huang
Summary: This study demonstrates that berberine can protect neurons against A beta 25-35-induced neurotoxicity in HT22 cells by relieving oxidative stress and inhibiting the mitochondrial pathway of cellular apoptosis.
BIOORGANIC CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Sizhen Li, Qingsong Yang, Zixiu Zhou, Xiaodong Yang, Yating Liu, Kuanxiao Hao, Min Fu
Summary: This study identified the protective effect of gastrodin on the injury of R28 cells induced by oxygen and glucose deprivation/reoxygenation. The activation of the PI3K/AKT/Nrf2 signaling pathway was involved in this process.
Article
Biochemistry & Molecular Biology
Yosuke Tabei, Hiroko Abe, Shingo Suzuki, Nobuaki Takeda, Jun-ichiro Arai, Yoshihiro Nakajima
Summary: This study demonstrated that Sedanolide enhances cellular resistance to oxidative damage through the activation of the KEAP1-NRF2 pathway and upregulation of antioxidant enzymes. Additionally, Sedanolide attenuates cytosolic and mitochondrial ROS generation induced by H2O2, thereby exerting cytoprotective effects against H2O2-induced cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yu-Ting Wu, Ling-Peng Xie, Yue Hua, Hong-Lin Xu, Guang-Hong Chen, Xin Han, Zhang-Bin Tan, Hui-Jie Fan, Hong-Mei Chen, Jun Li, Bin Liu, Ying-Chun Zhou
Summary: Tanshinone I (Tan I) protects cardiomyocytes against oxidative stress-induced injury by activating the Nrf2 signaling pathway, suggesting its potential therapeutic application for oxidative stress-induced cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Wenkai Huang, Yuan Zhong, Botao Gao, Bowen Zheng, Yi Liu
Summary: Oxidative stress (OS) occurs when the body's balance between oxidants and antioxidant defense systems is disrupted, leading to the development of various diseases. The transcription factor Nrf2, encoded by NFE2L2, plays a crucial role in regulating antioxidant enzymes and cytoprotective genes. Flavones, natural Nrf2 regulators, have shown therapeutic potential in diseases such as diabetes, neurodegenerative diseases, ischemia-reperfusion injury, and cancer. This review summarizes the protective effects of flavones mediated by Nrf2 in different conditions, including the mechanisms of how flavones regulate the Nrf2/ARE pathway and the evidence of their preventive effects in experimental models. The findings suggest that flavones targeting Nrf2 could serve as promising therapeutic agents for OS-related disorders. However, further studies on human subjects and the development of new drug delivery systems are needed to improve treatment efficiency.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huaxin Li, Mengxue Zhang, Yuanyu Wang, Ke Gong, Tengteng Yan, Dandan Wang, Xianshe Meng, Xiaoxiao Yang, Yuanli Chen, Jihong Han, Yajun Duan, Shuang Zhang
Summary: This study demonstrates that Daidzein (DAI) can alleviate heart failure (HF) by regulating cardiac energy metabolism, improving cardiac function, reducing inflammation, oxidative stress, apoptosis, and fibrosis.
Article
Pharmacology & Pharmacy
Xiaoliang Hu, Cheng Li, Qian Wang, Zhixing Wei, Taizhong Chen, Yuepeng Wang, Yigang Li
Summary: Doxorubicin, a drug with limited clinical application due to its cardiotoxicity, can be alleviated by Dimethyl fumarate (DMF) through reducing oxidative stress and apoptosis via Nrf2 pathway. The study found that DMF significantly improved cell viability and morphology, as well as alleviated DOX-induced cardiac injury, oxidative stress, and apoptosis. Moreover, DMF exerted its protective effects by promoting Nrf2 nuclear translocation and activating downstream antioxidant gene Hmox1. DMF may be a promising candidate to alleviate DOX-related cardiotoxicity in the future.
FRONTIERS IN PHARMACOLOGY
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)