Sex Differences in Pain

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

(2016) Sarah Taves et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuron–microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration

(2016) Makoto Tsuda et al.   NEUROPHARMACOLOGY

Biopsychosocial contributions to sex differences in pain

(2015) RB Fillingim   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Suppressive effects of androgens on the immune system

(2015) Abhishek Trigunaite et al.   CELLULAR IMMUNOLOGY

Estrogen receptors regulate innate immune cells and signaling pathways

(2015) Susan Kovats   CELLULAR IMMUNOLOGY

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-  Production in Women

(2015) M. Griesbeck et al.   JOURNAL OF IMMUNOLOGY

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

(2015) Zhonghui Guan et al.   NATURE NEUROSCIENCE

Sex differences in a Murine Model of Complex Regional Pain Syndrome

(2015) Maral Tajerian et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Inflammation-induced pain sensitization in men and women

(2015) Alexander Wegner et al.   PAIN

Sex hormones modulate the immune response to Plasmodium berghei ANKA in CBA/Ca mice

(2015) Martha Legorreta-Herrera et al.   PARASITOLOGY RESEARCH

Sex Differences in Peripheral Mu-Opioid Receptor Mediated Analgesia in Rat Orofacial Persistent Pain Model

(2015) Xiaofeng Bai et al.   PLoS One

IL-4 Is Required for Sex Differences in Vulnerability to Focal Ischemia in Mice

(2015) Xiaoxing Xiong et al.   STROKE

Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states

(2015) Shimona Madalli et al.   Biology of Sex Differences

Sex and Disease-Related Alterations of Anterior Insula Functional Connectivity in Chronic Abdominal Pain

(2014) J.-Y. Hong et al.   JOURNAL OF NEUROSCIENCE

Sex Differences in the Neural Representation of Pain Unpleasantness

(2014) Lydia Girard-Tremblay et al.   JOURNAL OF PAIN

Policy: NIH to balance sex in cell and animal studies

(2014) Janine A. Clayton et al.   NATURE

Sex differences in experimental pain among healthy children: A systematic review and meta-analysis

(2014) Katelynn E. Boerner et al.   PAIN

Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation

(2014) Haydn T. Kissick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex hormones in the modulation of irritable bowel syndrome

(2014) Agata Mulak   WORLD JOURNAL OF GASTROENTEROLOGY

Sex differences in mechanical allodynia: how can it be preclinically quantified and analyzed?

(2014) Lauren Nicotra et al.   Frontiers in Behavioral Neuroscience

Sex differences in a mouse model of multiple sclerosis: neuropathic pain behavior in females but not males and protection from neurological deficits during proestrus

(2014) Elizabeth J Rahn et al.   Biology of Sex Differences

Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen

(2014) Hongye Fan et al.   Journal of Immunology Research

Female sex hormones ameliorate arthritis in SKG mice

(2013) Kazuki Inoue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sex differences in formalin-evoked primary afferent release of substance P

(2013) A. Nazarian et al.   EUROPEAN JOURNAL OF PAIN

Estradiol downregulates NF-κb translocation by Ikbkg transcriptional repression in dendritic cells

(2013) S Lasarte et al.   GENES AND IMMUNITY

Microglial Regulation of Neuropathic Pain

(2013) Makoto Tsuda et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The known knowns of microglia–neuronal signalling in neuropathic pain

(2013) Simon Beggs et al.   NEUROSCIENCE LETTERS

Sex-independent suppression of experimental inflammatory pain by minocycline in two mouse strains

(2013) Leandro F.S. Bastos et al.   NEUROSCIENCE LETTERS

Fatigue-enhanced hyperalgesia in response to muscle insult: Induction and development occur in a sex-dependent manner

(2013) Nicholas S. Gregory et al.   PAIN

Higher pain perception and lack of recovery from neuropathic pain in females: A behavioural, immunohistochemical, and proteomic investigation on sex-related differences in mice

(2013) Valentina Vacca et al.   PAIN

Gender differences in sepsis

(2013) Martin K Angele et al.   Virulence

Sex differences matter in the gut: effect on mucosal immune activation and inflammation

(2013) Sumathi Sankaran-Walters et al.   Biology of Sex Differences

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

(2012) Robert E Sorge et al.   NATURE MEDICINE

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

(2012) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Role of Astrocytes in Pain

(2012) C.-Y. Chiang et al.   NEUROCHEMICAL RESEARCH

Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain

(2012) Tuan Trang et al.   Neuron Glia Biology

Peroxisome proliferator-activated receptor (PPAR)  and -  regulate IFN  and IL-17A production by human T cells in a sex-specific way

(2012) M. A. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats

(2012) Lisa C. Loram et al.   PSYCHONEUROENDOCRINOLOGY

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

(2012) Takahiro Masuda et al.   Cell Reports

Decoy strategy targeting the brain-derived neurotrophic factor exon I to attenuate tactile allodynia in the neuropathic pain model of rats

(2011) Norihiko Obata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice

(2011) R. S. Scotland et al.   BLOOD

Gender effect on in vitro lymphocyte subset levels of healthy individuals

(2011) Maha Abdullah et al.   CELLULAR IMMUNOLOGY

ATP receptors gate microglia signaling in neuropathic pain

(2011) Tuan Trang et al.   EXPERIMENTAL NEUROLOGY

Sex Differences in Neuropeptide Content and Release from Rat Dental Pulp

(2011) Walter R. Bowles et al.   JOURNAL OF ENDODONTICS

Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

(2011) R. E. Sorge et al.   JOURNAL OF NEUROSCIENCE

A systematic literature review of 10 years of research on sex/gender and experimental pain perception – Part 1: Are there really differences between women and men?

(2011) Mélanie Racine et al.   PAIN

Sex differences in autoimmune diseases

(2011) Rhonda Voskuhl   Biology of Sex Differences

Immune response by microglia in the spinal cord

(2010) Julie K. Olson   Annals of the New York Academy of Sciences

The Unexplained Female Predominance of Systemic Lupus Erythematosus: Clues from Genetic and Cytokine Studies

(2010) Corinna E. Weckerle et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Microglia–neuronal signalling in neuropathic pain hypersensitivity 2.0

(2010) Simon Beggs et al.   CURRENT OPINION IN NEUROBIOLOGY

Is BDNF Sufficient for Information Transfer between Microglia and Dorsal Horn Neurons during the Onset of Central Sensitization?

(2010) James E Biggs et al.   Molecular Pain

Males still dominate animal studies

(2010) Irving Zucker et al.   NATURE

Sex bias in neuroscience and biomedical research

(2010) Annaliese K. Beery et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4

(2009) E. Carreras et al.   BLOOD

T-Cell Infiltration and Signaling in the Adult Dorsal Spinal Cord Is a Major Contributor to Neuropathic Pain-Like Hypersensitivity

(2009) M. Costigan et al.   JOURNAL OF NEUROSCIENCE

P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation

(2009) T. Trang et al.   JOURNAL OF NEUROSCIENCE

Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

(2009) Roger B. Fillingim et al.   JOURNAL OF PAIN

Sex-related differences in pain

(2009) Brian E. Cairns et al.   MATURITAS

IFN-  receptor signaling mediates spinal microglia activation driving neuropathic pain

(2009) M. Tsuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gonadectomy of male BALB/c mice increases Tim-3+ alternatively activated M2 macrophages, Tim-3+ T cells, Th2 cells and Treg in the heart during acute coxsackievirus-induced myocarditis

(2008) Sylvia Frisancho-Kiss et al.   BRAIN BEHAVIOR AND IMMUNITY

Up-Regulation of P2X4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

(2008) L. Ulmann et al.   JOURNAL OF NEUROSCIENCE

TLR SIGNALING PATHWAY IN PATIENTS WITH SEPSIS

(2008) Reinaldo Salomão et al.   SHOCK

Role of Toll-like receptor responses for sepsis pathogenesis

(2007) Heike Weighardt et al.   IMMUNOBIOLOGY