RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma

The RhoGEF Trio: A Protein with a Wide Range of Functions in the Vascular Endothelium

(2021) Lanette Kempers et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting signaling pathways of VEGFR1 and VEGFR2 as a potential target in the treatment of breast cancer

(2020) Maryam Farzaneh Behelgardi et al.   MOLECULAR BIOLOGY REPORTS

Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression

(2020) Sylvie Brassart-Pasco et al.   Frontiers in Oncology

Targeting Rho GTPase Signaling Networks in Cancer

(2020) Natasha S. Clayton et al.   Frontiers in Cell and Developmental Biology

IQGAP1 causes choroidal neovascularization by sustaining VEGFR2-mediated Rac1 activation

(2020) Haibo Wang et al.   ANGIOGENESIS

RAC1 induces nuclear alterations through the LINC complex to enhance melanoma invasiveness

(2020) Paula Colón-Bolea et al.   MOLECULAR BIOLOGY OF THE CELL

NF1-RAC1 axis regulates migration of the melanocytic lineage

(2020) Lionel Larribère et al.   Translational Oncology

Defining the Hallmarks of Metastasis

(2019) Danny R. Welch et al.   CANCER RESEARCH

Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells

(2019) Ashwathi S. Mohan et al.   DEVELOPMENTAL CELL

RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance

(2019) Daniël A. Lionarons et al.   CANCER CELL

A feedforward relationship between active Rac1 and phosphorylated Bcl-2 is critical for sustaining Bcl-2 phosphorylation and promoting cancer progression

(2019) Stephen Jun Fei Chong et al.   CANCER LETTERS

Activation of endothelial ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and angiogenesis via activating Pak1 in mice

(2019) Fan Bu et al.   EXPERIMENTAL NEUROLOGY

Deacetylmycoepoxydiene is an agonist of Rac1, and simultaneously induces autophagy and apoptosis

(2018) Wei Xie et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1 P29S mutation

(2018) Takahiro Tomino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Rac and Cdc42 GTPases in Cancer

(2018) María del Mar Maldonado et al.   CANCER RESEARCH

Post-Translational Modification and Subcellular Distribution of Rac1: An Update

(2018) Abdalla Abdrabou et al.   Cells

Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer

(2017) Tessa Humphries-Bickley et al.   MOLECULAR CANCER THERAPEUTICS

Suppression of RAC1-driven malignant melanoma by group A PAK inhibitors

(2017) D Araiza-Olivera et al.   ONCOGENE

Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis

(2016) Nijiro Nohata et al.   DEVELOPMENTAL BIOLOGY

The involvement of mutant Rac1 in the formation of invadopodia in cultured melanoma cells

(2016) Or-Yam Revach et al.   EXPERIMENTAL CELL RESEARCH

IQGAP1 Interaction with RHO Family Proteins Revisited

(2016) Kazem Nouri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

(2016) Joachim Rudolph et al.   JOURNAL OF MEDICINAL CHEMISTRY

P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer

(2016) Hira Lal Goel et al.   Cell Reports

Rac1 Nucleocytoplasmic Shuttling Drives Nuclear Shape Changes and Tumor Invasion

(2015) Inmaculada Navarro-Lérida et al.   DEVELOPMENTAL CELL

A Rac1-Independent Role for P-Rex1 in Melanoblasts

(2015) Colin R. Lindsay et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets

(2015) S. Dütting et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

RAC1 P29S regulates PD-L1 expression in melanoma

(2015) Ha Linh Vu et al.   Pigment Cell & Melanoma Research

Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56  stabilizes its antiapoptotic activity

(2014) I. C. C. Low et al.   BLOOD

The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF

(2014) Ian R. Watson et al.   CANCER RESEARCH

Redox Modification of Nuclear Actin by MICAL-2 Regulates SRF Signaling

(2014) Mark R. Lundquist et al.   CELL

Targeting protein palmitoylation: selective inhibitors and implications in disease

(2014) Burzin Chavda et al.   Expert Opinion on Drug Discovery

A Trio–Rac1–Pak1 signalling axis drives invadopodia disassembly

(2014) Yasmin Moshfegh et al.   NATURE CELL BIOLOGY

Clinical and pathological associations of the activatingRAC1P29S mutation in primary cutaneous melanoma

(2014) Victoria J. Mar et al.   Pigment Cell & Melanoma Research

RPEL Proteins Are the Molecular Targets for CCG-1423, an Inhibitor of Rho Signaling

(2014) Ken’ichiro Hayashi et al.   PLoS One

The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model

(2014) Linette Castillo-Pichardo et al.   Translational Oncology

Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines

(2013) Georgina Cardama et al.   Anti-Cancer Agents in Medicinal Chemistry

Statins Exert the Pleiotropic Effects Through Small GTP-Binding Protein Dissociation Stimulator Upregulation With a Resultant Rac1 Degradation

(2013) Shin-ichi Tanaka et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells

(2013) Drazen B Zimonjic et al.   BMC CANCER

RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

(2013) Ralph Fritsch et al.   CELL

Factors That Predict Short-term Intensive Care Unit Mortality in Patients With Cirrhosis

(2013) Ranjeeta Bahirwani et al.   Clinical Gastroenterology and Hepatology

p21-Activated Kinase 1 (PAK1) Can Promote ERK Activation in a Kinase-independent Manner

(2013) Zhipeng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Small GTPase Protein Rac1 in Cardiovascular Diseases

(2013) Nicola Ferri et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

RAC1: An Emerging Therapeutic Option for Targeting Cancer Angiogenesis and Metastasis

(2013) H. K. Bid et al.   MOLECULAR CANCER THERAPEUTICS

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

(2013) D R Cook et al.   ONCOGENE

RAC1P29S is a spontaneously activating cancer-associated GTPase

(2013) M. J. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

(2013) E. M. Van Allen et al.   Cancer Discovery

Rational Design of Small Molecule Inhibitors Targeting the Rac GTPase-p67phox Signaling Axis in Inflammation

(2012) Emily E. Bosco et al.   CHEMISTRY & BIOLOGY

Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase

(2012) Brenda L. Montalvo-Ortiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative Activation of PI3K by Ras and Rho Family Small GTPases

(2012) Hee Won Yang et al.   MOLECULAR CELL

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Prenyltransferase inhibitors: treating human ailments from cancer to parasitic infections

(2012) Joshua D. Ochocki et al.   MedChemComm

Pirin Inhibits Cellular Senescence in Melanocytic Cells

(2011) Silvia Licciulli et al.   AMERICAN JOURNAL OF PATHOLOGY

Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach

(2011) P. Vader et al.   ANGIOGENESIS

Bisphosphonates: The first 40years

(2011) R. Graham G. Russell   BONE

The diverse roles of Rac signaling in tumorigenesis

(2011) Natalie A. Mack et al.   CELL CYCLE

Rac signaling in breast cancer: A tale of GEFs and GAPs

(2011) Eva Wertheimer et al.   CELLULAR SIGNALLING

Simvastatin stimulates apoptosis in cholangiocarcinoma by inhibition of Rac1 activity

(2011) Timothy Miller et al.   DIGESTIVE AND LIVER DISEASE

A palmitoylation switch mechanism regulates Rac1 function and membrane organization

(2011) Inmaculada Navarro-Lérida et al.   EMBO JOURNAL

Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice

(2011) Omar M. Khan et al.   JOURNAL OF CLINICAL INVESTIGATION

FERM Domain Phosphoinositide Binding Targets Merlin to the Membrane and Is Essential for Its Growth-Suppressive Function

(2011) T. Mani et al.   MOLECULAR AND CELLULAR BIOLOGY

Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma

(2010) Ryosuke Hino et al.   CANCER

Rac1 Recruits the Adapter Protein CMS/CD2AP to Cell-Cell Contacts

(2010) Trynette J. van Duijn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ccm1 Regulates Microvascular Morphogenesis during Angiogenesis

(2010) Huiling Liu et al.   JOURNAL OF VASCULAR RESEARCH

A small-molecule inhibitor shows that pirin regulates migration of melanoma cells

(2010) Isao Miyazaki et al.   Nature Chemical Biology

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The best way to determine the best way to undertake a hysterectomy

(2009) J Melendez et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

A Cell Active Chemical GEF Inhibitor Selectively Targets the Trio/RhoG/Rac1 Signaling Pathway

(2009) Nathalie Bouquier et al.   CHEMISTRY & BIOLOGY

Virtual Screening Approach for the Identification of New Rac1 Inhibitors

(2009) Nicola Ferri et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I

(2009) J. Lu et al.   MOLECULAR CANCER THERAPEUTICS

Palmitoyl acyltransferase assays and inhibitors (Review)

(2009) Jeremiah M. Draper et al.   MOLECULAR MEMBRANE BIOLOGY

The angiogenic switch in carcinogenesis

(2009) Vanessa Baeriswyl et al.   SEMINARS IN CANCER BIOLOGY

The Staging of Cancer: A Retrospective and Prospective Appraisal

(2008) F. L. Greene et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Protein Phosphatase Activity of PTEN Regulates Src Family Kinases and Controls Glioma Migration

(2008) N. Dey et al.   CANCER RESEARCH

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

An essential role for Rac1 in endothelial cell function and vascular development

(2008) Wenfu Tan et al.   FASEB JOURNAL

Rho GTPases in cancer cell biology

(2008) Francisco M. Vega et al.   FEBS LETTERS