标题
RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma
作者
关键词
-
出版物
Biomolecules
Volume 11, Issue 11, Pages 1554
出版商
MDPI AG
发表日期
2021-10-21
DOI
10.3390/biom11111554
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The RhoGEF Trio: A Protein with a Wide Range of Functions in the Vascular Endothelium
- (2021) Lanette Kempers et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Targeting signaling pathways of VEGFR1 and VEGFR2 as a potential target in the treatment of breast cancer
- (2020) Maryam Farzaneh Behelgardi et al. MOLECULAR BIOLOGY REPORTS
- Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression
- (2020) Sylvie Brassart-Pasco et al. Frontiers in Oncology
- Targeting Rho GTPase Signaling Networks in Cancer
- (2020) Natasha S. Clayton et al. Frontiers in Cell and Developmental Biology
- IQGAP1 causes choroidal neovascularization by sustaining VEGFR2-mediated Rac1 activation
- (2020) Haibo Wang et al. ANGIOGENESIS
- RAC1 induces nuclear alterations through the LINC complex to enhance melanoma invasiveness
- (2020) Paula Colón-Bolea et al. MOLECULAR BIOLOGY OF THE CELL
- NF1-RAC1 axis regulates migration of the melanocytic lineage
- (2020) Lionel Larribère et al. Translational Oncology
- Defining the Hallmarks of Metastasis
- (2019) Danny R. Welch et al. CANCER RESEARCH
- Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells
- (2019) Ashwathi S. Mohan et al. DEVELOPMENTAL CELL
- RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance
- (2019) Daniël A. Lionarons et al. CANCER CELL
- A feedforward relationship between active Rac1 and phosphorylated Bcl-2 is critical for sustaining Bcl-2 phosphorylation and promoting cancer progression
- (2019) Stephen Jun Fei Chong et al. CANCER LETTERS
- Activation of endothelial ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and angiogenesis via activating Pak1 in mice
- (2019) Fan Bu et al. EXPERIMENTAL NEUROLOGY
- Deacetylmycoepoxydiene is an agonist of Rac1, and simultaneously induces autophagy and apoptosis
- (2018) Wei Xie et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1 P29S mutation
- (2018) Takahiro Tomino et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Targeting Rac and Cdc42 GTPases in Cancer
- (2018) María del Mar Maldonado et al. CANCER RESEARCH
- Post-Translational Modification and Subcellular Distribution of Rac1: An Update
- (2018) Abdalla Abdrabou et al. Cells
- Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer
- (2017) Tessa Humphries-Bickley et al. MOLECULAR CANCER THERAPEUTICS
- Suppression of RAC1-driven malignant melanoma by group A PAK inhibitors
- (2017) D Araiza-Olivera et al. ONCOGENE
- Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis
- (2016) Nijiro Nohata et al. DEVELOPMENTAL BIOLOGY
- The involvement of mutant Rac1 in the formation of invadopodia in cultured melanoma cells
- (2016) Or-Yam Revach et al. EXPERIMENTAL CELL RESEARCH
- IQGAP1 Interaction with RHO Family Proteins Revisited
- (2016) Kazem Nouri et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window
- (2016) Joachim Rudolph et al. JOURNAL OF MEDICINAL CHEMISTRY
- P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer
- (2016) Hira Lal Goel et al. Cell Reports
- Rac1 Nucleocytoplasmic Shuttling Drives Nuclear Shape Changes and Tumor Invasion
- (2015) Inmaculada Navarro-Lérida et al. DEVELOPMENTAL CELL
- A Rac1-Independent Role for P-Rex1 in Melanoblasts
- (2015) Colin R. Lindsay et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets
- (2015) S. Dütting et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- RAC1 P29S regulates PD-L1 expression in melanoma
- (2015) Ha Linh Vu et al. Pigment Cell & Melanoma Research
- Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56 stabilizes its antiapoptotic activity
- (2014) I. C. C. Low et al. BLOOD
- The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF
- (2014) Ian R. Watson et al. CANCER RESEARCH
- Redox Modification of Nuclear Actin by MICAL-2 Regulates SRF Signaling
- (2014) Mark R. Lundquist et al. CELL
- Targeting protein palmitoylation: selective inhibitors and implications in disease
- (2014) Burzin Chavda et al. Expert Opinion on Drug Discovery
- A Trio–Rac1–Pak1 signalling axis drives invadopodia disassembly
- (2014) Yasmin Moshfegh et al. NATURE CELL BIOLOGY
- Clinical and pathological associations of the activatingRAC1P29S mutation in primary cutaneous melanoma
- (2014) Victoria J. Mar et al. Pigment Cell & Melanoma Research
- RPEL Proteins Are the Molecular Targets for CCG-1423, an Inhibitor of Rho Signaling
- (2014) Ken’ichiro Hayashi et al. PLoS One
- The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model
- (2014) Linette Castillo-Pichardo et al. Translational Oncology
- Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines
- (2013) Georgina Cardama et al. Anti-Cancer Agents in Medicinal Chemistry
- Statins Exert the Pleiotropic Effects Through Small GTP-Binding Protein Dissociation Stimulator Upregulation With a Resultant Rac1 Degradation
- (2013) Shin-ichi Tanaka et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells
- (2013) Drazen B Zimonjic et al. BMC CANCER
- RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms
- (2013) Ralph Fritsch et al. CELL
- Factors That Predict Short-term Intensive Care Unit Mortality in Patients With Cirrhosis
- (2013) Ranjeeta Bahirwani et al. Clinical Gastroenterology and Hepatology
- p21-Activated Kinase 1 (PAK1) Can Promote ERK Activation in a Kinase-independent Manner
- (2013) Zhipeng Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of Small GTPase Protein Rac1 in Cardiovascular Diseases
- (2013) Nicola Ferri et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- RAC1: An Emerging Therapeutic Option for Targeting Cancer Angiogenesis and Metastasis
- (2013) H. K. Bid et al. MOLECULAR CANCER THERAPEUTICS
- Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease
- (2013) D R Cook et al. ONCOGENE
- RAC1P29S is a spontaneously activating cancer-associated GTPase
- (2013) M. J. Davis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma
- (2013) E. M. Van Allen et al. Cancer Discovery
- Rational Design of Small Molecule Inhibitors Targeting the Rac GTPase-p67phox Signaling Axis in Inflammation
- (2012) Emily E. Bosco et al. CHEMISTRY & BIOLOGY
- Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase
- (2012) Brenda L. Montalvo-Ortiz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cooperative Activation of PI3K by Ras and Rho Family Small GTPases
- (2012) Hee Won Yang et al. MOLECULAR CELL
- Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
- (2012) Michael Krauthammer et al. NATURE GENETICS
- Prenyltransferase inhibitors: treating human ailments from cancer to parasitic infections
- (2012) Joshua D. Ochocki et al. MedChemComm
- Pirin Inhibits Cellular Senescence in Melanocytic Cells
- (2011) Silvia Licciulli et al. AMERICAN JOURNAL OF PATHOLOGY
- Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach
- (2011) P. Vader et al. ANGIOGENESIS
- Bisphosphonates: The first 40years
- (2011) R. Graham G. Russell BONE
- The diverse roles of Rac signaling in tumorigenesis
- (2011) Natalie A. Mack et al. CELL CYCLE
- Rac signaling in breast cancer: A tale of GEFs and GAPs
- (2011) Eva Wertheimer et al. CELLULAR SIGNALLING
- Simvastatin stimulates apoptosis in cholangiocarcinoma by inhibition of Rac1 activity
- (2011) Timothy Miller et al. DIGESTIVE AND LIVER DISEASE
- A palmitoylation switch mechanism regulates Rac1 function and membrane organization
- (2011) Inmaculada Navarro-Lérida et al. EMBO JOURNAL
- Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice
- (2011) Omar M. Khan et al. JOURNAL OF CLINICAL INVESTIGATION
- FERM Domain Phosphoinositide Binding Targets Merlin to the Membrane and Is Essential for Its Growth-Suppressive Function
- (2011) T. Mani et al. MOLECULAR AND CELLULAR BIOLOGY
- Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma
- (2010) Ryosuke Hino et al. CANCER
- Rac1 Recruits the Adapter Protein CMS/CD2AP to Cell-Cell Contacts
- (2010) Trynette J. van Duijn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ccm1 Regulates Microvascular Morphogenesis during Angiogenesis
- (2010) Huiling Liu et al. JOURNAL OF VASCULAR RESEARCH
- A small-molecule inhibitor shows that pirin regulates migration of melanoma cells
- (2010) Isao Miyazaki et al. Nature Chemical Biology
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- The best way to determine the best way to undertake a hysterectomy
- (2009) J Melendez et al. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
- A Cell Active Chemical GEF Inhibitor Selectively Targets the Trio/RhoG/Rac1 Signaling Pathway
- (2009) Nathalie Bouquier et al. CHEMISTRY & BIOLOGY
- Virtual Screening Approach for the Identification of New Rac1 Inhibitors
- (2009) Nicola Ferri et al. JOURNAL OF MEDICINAL CHEMISTRY
- In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I
- (2009) J. Lu et al. MOLECULAR CANCER THERAPEUTICS
- Palmitoyl acyltransferase assays and inhibitors (Review)
- (2009) Jeremiah M. Draper et al. MOLECULAR MEMBRANE BIOLOGY
- The angiogenic switch in carcinogenesis
- (2009) Vanessa Baeriswyl et al. SEMINARS IN CANCER BIOLOGY
- The Staging of Cancer: A Retrospective and Prospective Appraisal
- (2008) F. L. Greene et al. CA-A CANCER JOURNAL FOR CLINICIANS
- The Protein Phosphatase Activity of PTEN Regulates Src Family Kinases and Controls Glioma Migration
- (2008) N. Dey et al. CANCER RESEARCH
- Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement
- (2008) Victoria Sanz-Moreno et al. CELL
- An essential role for Rac1 in endothelial cell function and vascular development
- (2008) Wenfu Tan et al. FASEB JOURNAL
- Rho GTPases in cancer cell biology
- (2008) Francisco M. Vega et al. FEBS LETTERS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started