The diverse roles of Rac signaling in tumorigenesis

SUMO and ubiquitin paths converge

(2010) Amanda Denuc et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Rac and Rho GTPases in cancer cell motility control

(2010) Matteo Parri et al.   Cell Communication and Signaling

Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression

(2010) Simon A. Woodcock et al.   CURRENT BIOLOGY

The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly

(2010) Claire Rooney et al.   EMBO REPORTS

Tight Junctions: A Barrier to the Initiation and Progression of Breast Cancer?

(2010) Kieran Brennan et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway

(2010) M. Nethe et al.   JOURNAL OF CELL SCIENCE

Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1

(2010) Etienne Boulter et al.   NATURE CELL BIOLOGY

SUMOylation of the GTPase Rac1 is required for optimal cell migration

(2010) Sonia Castillo-Lluva et al.   NATURE CELL BIOLOGY

The role of fibroblast Tiam1 in tumor cell invasion and metastasis

(2010) K Xu et al.   ONCOGENE

Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo

(2010) Z Wang et al.   ONCOGENE

Dynamics and functions of tight junctions

(2010) Emily Steed et al.   TRENDS IN CELL BIOLOGY

Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells

(2009) Beatrix Hage et al.   Cell Communication and Signaling

TLR2-Induced Calpain Cleavage of Epithelial Junctional Proteins Facilitates Leukocyte Transmigration

(2009) Jarin Chun et al.   Cell Host & Microbe

Polarity proteins regulate mammalian cell–cell junctions and cancer pathogenesis

(2009) Michael E Feigin et al.   CURRENT OPINION IN CELL BIOLOGY

Nuclear cyclin D1: An oncogenic driver in human cancer

(2009) Jong Kyong Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Src-Induced Disassembly of Adherens Junctions Requires Localized Phosphorylation and Degradation of the Rac Activator Tiam1

(2009) Simon A. Woodcock et al.   MOLECULAR CELL

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis

(2009) J Qin et al.   ONCOGENE

Tight junctions and the regulation of gene expression

(2008) Maria S. Balda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

Novel role of nectin: implication in the co-localization of JAM-A and claudin-1 at the same cell-cell adhesion membrane domain

(2008) Kaori Kuramitsu et al.   GENES TO CELLS

Joint Requirement for Rac and ERK Activities Underlies the Mid-G1 Phase Induction of Cyclin D1 and S Phase Entry in Both Epithelial and Mesenchymal Cells

(2008) Eric A. Klein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rho Family GTPase Modification and Dependence on CAAXMotif-signaled Posttranslational Modification

(2008) Patrick J. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tiam1 and Rac1 Are Required for Platelet-activating Factor-induced Endothelial Junctional Disassembly and Increase in Vascular Permeability

(2008) Ivana I. Knezevic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division

(2008) David Michaelson et al.   JOURNAL OF CELL BIOLOGY

PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac

(2008) E. Lozano et al.   JOURNAL OF CELL SCIENCE

Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis

(2008) E K Thomas et al.   LEUKEMIA

Rac guanosine triphosphatases represent a potential target in AML

(2008) L U W Müller et al.   LEUKEMIA

Increased Rac1b Expression Sustains Colorectal Tumor Cell Survival

(2008) P. Matos et al.   MOLECULAR CANCER RESEARCH

Regulation of cytokinesis by Rho GTPase flux

(2008) Ann L. Miller et al.   NATURE CELL BIOLOGY

Inhibition of Rac by the GAP Activity of Centralspindlin Is Essential for Cytokinesis

(2008) J. C. Canman et al.   SCIENCE

A Critical Role for Rac1 in Tumor Progression of Human Colorectal Adenocarcinoma Cells

(2007) Carolina Espina et al.   AMERICAN JOURNAL OF PATHOLOGY