Clinical and pathological associations of the activatingRAC1P29S mutation in primary cutaneous melanoma

A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma

(2013) Julie Caramel et al.   CANCER CELL

BRAF/NRAS Wild-Type Melanomas Have a High Mutation Load Correlating with Histologic and Molecular Signatures of UV Damage

(2013) V. J. Mar et al.   CLINICAL CANCER RESEARCH

Constitutive Rac Activation Is Not Sufficient to Initiate Melanocyte Neoplasia but Accelerates Malignant Progression

(2013) Lucy E. Dalton et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

P21-Activated Kinase 1 (PAK1) as a Therapeutic Target in BRAF Wild-Type Melanoma

(2013) Christy C. Ong et al.   JNCI-Journal of the National Cancer Institute

Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities

(2013) R A Patel et al.   ONCOGENE

Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1

(2013) P Wang et al.   ONCOGENE

P-Rex1 Cooperates with PDGFRβ to Drive Cellular Migration in 3D Microenvironments

(2013) Andrew D. Campbell et al.   PLoS One

Impact of deleterious passenger mutations on cancer progression

(2013) C. D. McFarland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RAC1P29S is a spontaneously activating cancer-associated GTPase

(2013) M. J. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma

(2013) Anna Richter et al.   Scientific Reports

Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression

(2013) Shannon Patricia Fortin Ensign et al.   Frontiers in Oncology

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Activated Mutant NRasQ61K Drives Aberrant Melanocyte Signaling, Survival, and Invasiveness via a Rac1-Dependent Mechanism

(2012) Ang Li et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Mutant B-RAF regulates a Rac-dependent cadherin switch in melanoma

(2012) E Monaghan-Benson et al.   ONCOGENE

Rac1 in the driver’s seat for melanoma

(2012) Laura M. Machesky et al.   Pigment Cell & Melanoma Research

NRAS mutation status is an independent prognostic factor in metastatic melanoma

(2011) John A. Jakob et al.   CANCER

Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma

(2011) Bianca Devitt et al.   Pigment Cell & Melanoma Research

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

(2011) Colin R. Lindsay et al.   Nature Communications

Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer

(2010) Takao Kamai et al.   BMC CANCER

Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression

(2010) Simon A. Woodcock et al.   CURRENT BIOLOGY

The role of ubiquitylation and degradation in RhoGTPase signalling

(2010) Micha Nethe et al.   JOURNAL OF CELL SCIENCE

Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo

(2010) Z Wang et al.   ONCOGENE

Genetic and morphologic features for melanoma classification

(2010) Sigrid M. C. Broekaert et al.   Pigment Cell & Melanoma Research

V600EBRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

(2009) C. A. Pratilas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

Improving Melanoma Classification by Integrating Genetic and Morphologic Features

(2008) Amaya Viros et al.   PLOS MEDICINE