Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets

Liposome Reconstitution and Modulation of Recombinant Prenylated Human Rac1 by GEFs, GDI1 and Pak1

(2014) Si-Cai Zhang et al.   PLoS One

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42

(2013) I. Pleines et al.   BLOOD

The Centrosomal Adaptor TACC3 and the Microtubule Polymerase chTOG Interact via Defined C-terminal Subdomains in an Aurora-A Kinase-independent Manner

(2013) Harish C. Thakur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The small GTPase Rac1 is required for smooth muscle contraction

(2013) Awahan Rahman et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Role of Rac1 in Glycoprotein Ib-IX–Mediated Signal Transduction and Integrin Activation

(2012) M. Keegan Delaney et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase

(2012) Brenda L. Montalvo-Ortiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maladaptive Dendritic Spine Remodeling Contributes to Diabetic Neuropathic Pain

(2012) A. M. Tan et al.   JOURNAL OF NEUROSCIENCE

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

(2012) Kazuko Haga et al.   NATURE

Rap1-Rac1 Circuits Potentiate Platelet Activation

(2011) Lucia Stefanini et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis

(2011) I. Pleines et al.   BLOOD

S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation

(2011) J. E. Aslan et al.   BLOOD

Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke

(2011) B. NIESWANDT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Arterial thrombosis—insidious, unpredictable and deadly

(2011) Shaun P Jackson   NATURE MEDICINE

Inhibition of Rac controls NPM–ALK-dependent lymphoma development and dissemination

(2011) A Colomba et al.   Blood Cancer Journal

Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets

(2010) I. Pleines et al.   BLOOD

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unraveling a novel Rac1-mediated signaling pathway that regulates cofilin dephosphorylation and secretion in thrombin-stimulated platelets

(2009) D. Pandey et al.   BLOOD

Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway

(2008) P. Flevaris et al.   BLOOD

Inhibition of Rac1 decreases the severity of pancreatitis and pancreatitis-associated lung injury in mice

(2008) Marcelo G. Binker et al.   EXPERIMENTAL PHYSIOLOGY

Rac guanosine triphosphatases represent a potential target in AML

(2008) L U W Müller et al.   LEUKEMIA

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

(2008) Shigeru Shibata et al.   NATURE MEDICINE

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rac1 is essential for phospholipase C-γ2 activation in platelets

(2008) Irina Pleines et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY