Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy

Control of T-Cell Activation and Signaling by Amino-Acid Catabolizing Enzymes

(2021) Flavia Castellano et al.   Frontiers in Cell and Developmental Biology

Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer

(2021) Gang Xin et al.   Cancer Immunology Research

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

The Role of Macrophages in Cancer Development and Therapy

(2021) Ewa Cendrowicz et al.   Cancers

Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages

(2020) Pan Su et al.   CANCER RESEARCH

Aberrant lipid metabolism in hepatocellular carcinoma cells as well as immune microenvironment: A review

(2020) Bo Hu et al.   CELL PROLIFERATION

Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity

(2020) Nina Dumauthioz et al.   Cellular & Molecular Immunology

The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment

(2020) Timothy P. Brown et al.   ONCOGENE

Fatty acid oxidation controls CD8+ tissue-resident memory T cell survival in gastric adenocarcinoma

(2020) Run Lin et al.   Cancer Immunology Research

Tumor-derived prostaglandin E2 promotes p50 NF-κB-dependent differentiation of monocytic MDSC

(2020) Chiara Porta et al.   CANCER RESEARCH

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

(2020) Min-Hee Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Connections between Metabolism and Epigenetic Modification in MDSCs

(2020) Haiyan Dai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

(2020) Yi-Ru Yu et al.   NATURE IMMUNOLOGY

IDO Expression in Cancer: Different Compartment, Different Functionality?

(2020) Annabel Meireson et al.   Frontiers in Immunology

Tumor-Associated Macrophages in Tumor Immunity

(2020) Yueyun Pan et al.   Frontiers in Immunology

Fatty acid transport protein 2 reprograms neutrophils in cancer

(2019) Filippo Veglia et al.   NATURE

Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics

(2019) Danielle Golub et al.   Frontiers in Oncology

Re-education of macrophages as a therapeutic strategy in cancer

(2019) Joanna Kowal et al.   Immunotherapy

Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor

(2019) Dehong Yan et al.   Frontiers in Immunology

Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer

(2019) Wen-Chao Wu et al.   Cancer Immunology Research

The Two Faces of Tumor-Associated Macrophages and Their Clinical Significance in Colorectal Cancer

(2019) Marta L. Pinto et al.   Frontiers in Immunology

Lactate Induces Pro-tumor Reprogramming in Intratumoral Plasmacytoid Dendritic Cells

(2019) Deblina Raychaudhuri et al.   Frontiers in Immunology

LOX-1+ PMN-MDSC enhances immune suppression which promotes glioblastoma multiforme progression

(2019) ErQing Chai et al.   Cancer Management and Research

Energy metabolism manipulates the fate and function of tumour myeloid-derived suppressor cells

(2019) Cong Hu et al.   BRITISH JOURNAL OF CANCER

Reprogramming of fatty acid metabolism in cancer

(2019) Nikos Koundouros et al.   BRITISH JOURNAL OF CANCER

LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer

(2018) Masoud F. Tavazoie et al.   CELL

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

(2018) Wei Li et al.   Cell Metabolism

Plasticity of myeloid-derived suppressor cells in cancer

(2018) Evgenii Tcyganov et al.   CURRENT OPINION IN IMMUNOLOGY

Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization

(2018) Fei Zhao et al.   IMMUNITY

Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis

(2018) Xiaoyue Zhao et al.   Scientific Reports

Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects

(2018) Takenori Uehara et al.   INTERNATIONAL IMMUNOLOGY

Synthesis of Novel Shikonin Derivatives and Pharmacological Effects of Cyclopropylacetylshikonin on Melanoma Cells

(2018) Christin Durchschein et al.   MOLECULES

Unique pattern of neutrophil migration and function during tumor progression

(2018) Sima Patel et al.   NATURE IMMUNOLOGY

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

(2018) Christopher M. Rice et al.   Nature Communications

Ovarian Cancer-Intrinsic Fatty Acid Synthase Prevents Anti-tumor Immunity by Disrupting Tumor-Infiltrating Dendritic Cells

(2018) Li Jiang et al.   Frontiers in Immunology

Glycolysis regulates the expansion of myeloid-derived suppressor cells in tumor-bearing hosts through prevention of ROS-mediated apoptosis

(2017) Shiou-Ling Jian et al.   Cell Death & Disease

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

(2017) Erika M. Palmieri et al.   Cell Reports

LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma

(2017) Ting-Ting Cai et al.   PLoS Pathogens

Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells

(2017) Amir A. Al-Khami et al.   OncoImmunology

A Dynamic Metabolic Flux Analysis of Myeloid-Derived Suppressor Cells Confirms Immunosuppression-Related Metabolic Plasticity

(2017) Guillaume Goffaux et al.   Scientific Reports

Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays

(2017) Daniel J. Urban et al.   Scientific Reports

T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells

(2016) Ilaria Marigo et al.   CANCER CELL

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Immunoregulatory and Effector Activities of Nitric Oxide and Reactive Nitrogen Species in Cancer

(2016) Cinzia Fionda et al.   CURRENT MEDICINAL CHEMISTRY

The impact of hypoxia on tumor-associated macrophages

(2016) Anne-Theres Henze et al.   JOURNAL OF CLINICAL INVESTIGATION

Comprehensive Proteomics Analysis Reveals Metabolic Reprogramming of Tumor-Associated Macrophages Stimulated by the Tumor Microenvironment

(2016) Di Liu et al.   JOURNAL OF PROTEOME RESEARCH

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

(2016) Hiroaki Semba et al.   Nature Communications

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment

(2016) Cara C. Schafer et al.   Oncotarget

Cancer-Associated Myeloid Regulatory Cells

(2016) Yannick De Vlaeminck et al.   Frontiers in Immunology

Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages

(2016) Rob J. W. Arts et al.   OncoImmunology

Shikonin Induces Apoptosis, Necrosis, and Premature Senescence of Human A549 Lung Cancer Cells through Upregulation of p53 Expression

(2015) Yueh-Chiao Yeh et al.   Evidence-based Complementary and Alternative Medicine

Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis

(2015) Ting Zhao et al.   Oncotarget

Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies

(2015) F. Hossain et al.   Cancer Immunology Research

The dual role of iNOS in cancer

(2015) Federica Vannini et al.   Redox Biology

Fatty Acid-Binding Protein E-FABP Restricts Tumor Growth by Promoting IFN-  Responses in Tumor-Associated Macrophages

(2014) Y. Zhang et al.   CANCER RESEARCH

Inhibition of Tumor-Derived Prostaglandin-E2 Blocks the Induction of Myeloid-Derived Suppressor Cells and Recovers Natural Killer Cell Activity

(2014) Y. Mao et al.   CLINICAL CANCER RESEARCH

Liver X receptors in lipid metabolism: opportunities for drug discovery

(2014) Cynthia Hong et al.   NATURE REVIEWS DRUG DISCOVERY

Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression

(2014) Damya Laoui et al.   Frontiers in Immunology

SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1 -Dependent Glycolysis

(2013) G. Liu et al.   CANCER RESEARCH

Enhanced suppressive capacity of tumor-infiltrating myeloid-derived suppressor cells compared with their peripheral counterparts

(2013) Sarah K. Maenhout et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells Suppress Antitumor Immune Responses through IDO Expression and Correlate with Lymph Node Metastasis in Patients with Breast Cancer

(2013) J. Yu et al.   JOURNAL OF IMMUNOLOGY

Macrophage-tumor cell interactions regulate the function of nitric oxide

(2013) Michal A. Rahat et al.   Frontiers in Physiology

A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

(2012) Luis E. Raez et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Nitric Oxide Produced Endogenously Is Responsible for Hypoxia-Induced HIF-1α Stabilization in Colon Carcinoma Cells

(2012) Rajdeep Chowdhury et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolism of L-Arginine by Myeloid-Derived Suppressor Cells in Cancer: Mechanisms of T cell suppression and Therapeutic Perspectives

(2012) Patrick Raber et al.   IMMUNOLOGICAL INVESTIGATIONS

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development

(2012) Courtney Smith et al.   Cancer Discovery

Tumor-Associated Macrophages Mediate Immunosuppression in the Renal Cancer Microenvironment by Activating the 15-Lipoxygenase-2 Pathway

(2011) I. Daurkin et al.   CANCER RESEARCH

Tumor-Associated Macrophages Promote Angiogenesis and Melanoma Growth via Adrenomedullin in a Paracrine and Autocrine Manner

(2011) P. Chen et al.   CLINICAL CANCER RESEARCH

Activated CD69+ T Cells Foster Immune Privilege by Regulating IDO Expression in Tumor-Associated Macrophages

(2011) Q. Zhao et al.   JOURNAL OF IMMUNOLOGY

Nitric oxide and redox mechanisms in the immune response

(2011) David A. Wink et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Methotrexate, Paclitaxel, and Doxorubicin Radiosensitize HER2-Amplified Human Breast Cancer Cells to the Auger Electron-Emitting Radiotherapeutic Agent 111In-NLS-Trastuzumab

(2010) D. L. Costantini et al.   JOURNAL OF NUCLEAR MEDICINE

Indoleamine 2,3-dioxygenase (IDO) activity influence tumor growth in the TRAMP prostate cancer model

(2010) Eva Källberg et al.   PROSTATE

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

PX-478, an inhibitor of hypoxia-inducible factor-1α, enhances radiosensitivity of prostate carcinoma cells

(2008) Sanjeewani T. Palayoor et al.   INTERNATIONAL JOURNAL OF CANCER