Aberrant lipid metabolism in hepatocellular carcinoma cells as well as immune microenvironment: A review

Aberrant lipid metabolism as a therapeutic target in liver cancer

(2019) Evans D. Pope et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans

(2019) Li Che et al.   GUT

Characterization of Lipid and Lipid Droplet Metabolism in Human HCC

(2019) Berndt et al.   Cells

Non-viral nano-immunotherapeutics targeting tumor microenvironmental immune cells

(2019) Seok-Beom Yong et al.   BIOMATERIALS

Investigation of lipid metabolism dysregulation and the effects on immune microenvironments in pan-cancer using multiple omics data

(2019) Yang Hao et al.   BMC BIOINFORMATICS

Sphere-forming culture enriches liver cancer stem cells and reveals Stearoyl-CoA desaturase 1 as a potential therapeutic target

(2019) Xiao-Lu Ma et al.   BMC CANCER

Intratumoral plasmacytoid dendritic cells as a poor prognostic factor for hepatocellular carcinoma following curative resection

(2019) Zheng-Jun Zhou et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

CXCR6 deficiency ameliorates ischemia-reperfusion injury by reducing the recruitment and cytokine production of hepatic NKT cells in a mouse model of non-alcoholic fatty liver disease

(2019) Huanbing Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

HBx combined with AFB1 triggers hepatic steatosis via COX‐2‐mediated necrosome formation and mitochondrial dynamics disorder

(2019) Yuan‐Yuan Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Metabolic flexibility in melanoma: A potential therapeutic target

(2019) Maria Rosaria Ruocco et al.   SEMINARS IN CANCER BIOLOGY

Metabolic Control of Dendritic Cell Functions: Digesting Information

(2019) Stefanie K. Wculek et al.   Frontiers in Immunology

Lipid metabolism and lipophagy in cancer

(2018) Meenu Maan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship

(2018) Romana T. Netea-Maier et al.   CANCER LETTERS

Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance

(2018) Hideki Iwamoto et al.   Cell Metabolism

CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity

(2018) Naoto Fujiwara et al.   GUT

β-catenin-activated hepatocellular carcinomas are addicted to fatty acids

(2018) Nadia Senni et al.   GUT

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Fatty acid oxidation contributes to IL-1β secretion in M2 macrophages and promotes macrophage-mediated tumor cell migration

(2018) Qi Zhang et al.   MOLECULAR IMMUNOLOGY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth

(2018) Ilenia Pacella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Droplets as Immune Modulators in Myeloid Cells

(2018) Martijn H. den Brok et al.   TRENDS IN IMMUNOLOGY

Regulatory T Cell Metabolism in the Hepatic Microenvironment

(2018) Rebecca Ellen Wawman et al.   Frontiers in Immunology

Lipid profiling of pre-treatment plasma reveals biomarker candidates associated with response rates and hand–foot skin reactions in sorafenib-treated patients

(2018) Kosuke Saito et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Development of an in vitro model to study hepatitis C virus effects on hepatocellular lipotoxicity and lipid metabolism

(2018) Leandra Koletzko et al.   PATHOLOGY RESEARCH AND PRACTICE

Immunometabolism: A novel perspective of liver cancer microenvironment and its influence on tumor progression

(2018) Qi Zhang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Integrative genomic analysis of mouse and human hepatocellular carcinoma

(2018) Michelle Dow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes

(2018) Gholamreza Bidkhori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonalcoholic Fatty Liver Disease

(2018) Irene Pierantonelli et al.   TRANSPLANTATION

Lipid Metabolic Reprogramming in Hepatocellular Carcinoma

(2018) Hayato Nakagawa et al.   Cancers

Fatty acid synthase (FASN) as a therapeutic target in breast cancer

(2017) Javier A. Menendez et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Pleiotrophin, a target of miR-384, promotes proliferation, metastasis and lipogenesis in HBV-related hepatocellular carcinoma

(2017) Pei-song Bai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation

(2017) Mark Kin Fai Ma et al.   JOURNAL OF HEPATOLOGY

Toxic effects of phytol and retinol on human glioblastoma cells are associated with modulation of cholesterol and fatty acid biosynthetic pathways

(2017) Gustavo Facchini et al.   JOURNAL OF NEURO-ONCOLOGY

Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells

(2017) Amir A. Al-Khami et al.   OncoImmunology

Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis

(2016) F. Geng et al.   CLINICAL CANCER RESEARCH

Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients

(2016) Ming-Da Wang et al.   HEPATOLOGY

The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements

(2016) Claudio Procaccini et al.   IMMUNITY

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

(2016) Lei Li et al.   JOURNAL OF HEPATOLOGY

Oral intake of 7-dehydrocholesterol increases vitamin D 3 concentrations in the liver and kidney

(2016) Julia Kühn et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

MicroRNA-1207-5p inhibits hepatocellular carcinoma cell growth and invasion through the fatty acid synthase-mediated Akt/mTOR signalling pathway

(2016) Gang Zhao et al.   ONCOLOGY REPORTS

PPARs and Mitochondrial Metabolism: From NAFLD to HCC

(2016) Tommaso Mello et al.   PPAR Research

Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation

(2016) Martijn H. den Brok et al.   Nature Communications

HBx regulates fatty acid oxidation to promote hepatocellular carcinoma survival during metabolic stress

(2016) Ming-Da Wang et al.   Oncotarget

Hepatitis B virus X induces inflammation and cancer in mice liver through dysregulation of cytoskeletal remodeling and lipid metabolism

(2016) Zhongwei Xu et al.   Oncotarget

Longitudinal metabolic imaging of hepatocellular carcinoma in transgenic mouse models identifies acylcarnitine as a potential biomarker for early detection

(2016) Jadegoud Yaligar et al.   Scientific Reports

Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation

(2016) Lorissa J. Smulan et al.   Cell Reports

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation

(2015) Maria Ida Malandrino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

(2015) Chao Wang et al.   CELL

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

Peroxisomal Lipid Synthesis Regulates Inflammation by Sustaining Neutrophil Membrane Phospholipid Composition and Viability

(2015) Irfan J. Lodhi et al.   Cell Metabolism

MicroRNAs and Noncoding RNAs in Hepatic Lipid and Lipoprotein Metabolism: Potential Therapeutic Targets of Metabolic Disorders

(2015) Neetu Sud et al.   DRUG DEVELOPMENT RESEARCH

MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway

(2015) Heng Wu et al.   GUT

Characterization of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) patients without cirrhosis

(2015) Bashar Mohamad et al.   Hepatology International

Metabolic Reprogramming of Immune Cells in Cancer Progression

(2015) Subhra K. Biswas   IMMUNITY

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma

(2015) Oscar W.H. Yeung et al.   JOURNAL OF HEPATOLOGY

Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment

(2015) Joanna M. Poczobutt et al.   JOURNAL OF IMMUNOLOGY

Tumor-Infiltrating Dendritic Cells in Cancer Pathogenesis

(2015) Jo Marie Tran Janco et al.   JOURNAL OF IMMUNOLOGY

A biphasic response pattern of lipid metabolomics in the stage progression of hepatitis B virus X tumorigenesis

(2015) Chiao-Fang Teng et al.   MOLECULAR CARCINOGENESIS

Metabolic control of regulatory T cell development and function

(2015) Hu Zeng et al.   TRENDS IN IMMUNOLOGY

Overexpression of microRNA-30a-5p inhibits liver cancer cell proliferation and induces apoptosis by targeting MTDH/PTEN/AKT pathway

(2015) Wen-fang Li et al.   TUMOR BIOLOGY

β-catenin alteration is rare in hepatocellular carcinoma with steatohepatitic features: immunohistochemical and mutational study

(2015) Sumiyo Ando et al.   VIRCHOWS ARCHIV

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPARβ/δ Activation in Tumor Myeloid Cells, Leading to Tumor Progression

(2015) Jonghanne Park et al.   Cell Reports

Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1

(2015) Yusuke Endo et al.   Cell Reports

Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies

(2015) Amir A Al-Khami et al.   Journal for ImmunoTherapy of Cancer

Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

(2015) Aritro Nath et al.   Scientific Reports

miR-613 regulates cholesterol efflux by targeting LXRα and ABCA1 in PPARγ activated THP-1 macrophages

(2014) Ranzun Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4

(2014) Ming Cui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA synthetase long-chain family member 1 (ACSL1) mRNA

(2014) Ming Cui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fatty Acid-Binding Protein E-FABP Restricts Tumor Growth by Promoting IFN-  Responses in Tumor-Associated Macrophages

(2014) Y. Zhang et al.   CANCER RESEARCH

LXR-dependent and -independent effects of oxysterols on immunity and tumor growth

(2014) Catia Traversari et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

PD-1 regulates extrathymic regulatory T-cell differentiation

(2014) Xiufen Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fatty acids increase hepatitis B virus X protein stabilization and HBx-induced inflammatory gene expression

(2014) Hyun Kook Cho et al.   FEBS Journal

Evaluation of cytotoxic effects of 7-dehydrocholesterol on melanoma cells

(2014) Monica Gelzo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia

(2014) Raymond Ng et al.   HEPATOLOGY

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy

(2014) Yuichiroh Umemoto et al.   JOURNAL OF GASTROENTEROLOGY

Oxidized Lipids Block Antigen Cross-Presentation by Dendritic Cells in Cancer

(2014) W. Cao et al.   JOURNAL OF IMMUNOLOGY

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Higher Frequencies of GARP+CTLA-4+Foxp3+ T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality

(2013) S. Kalathil et al.   CANCER RESEARCH

An SREBP-Responsive microRNA Operon Contributes to a Regulatory Loop for Intracellular Lipid Homeostasis

(2013) Tae-Il Jeon et al.   Cell Metabolism

Integrated Metabolite and Gene Expression Profiles Identify Lipid Biomarkers Associated With Progression of Hepatocellular Carcinoma and Patient Outcomes

(2013) Anuradha Budhu et al.   GASTROENTEROLOGY

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

(2013) Yoko Kidani et al.   NATURE IMMUNOLOGY

Genetic Analyses Reveal a Role for Vitamin D Insufficiency in HCV-Associated Hepatocellular Carcinoma Development

(2013) Christian M. Lange et al.   PLoS One

MiR-155 Has a Protective Role in the Development of Non-Alcoholic Hepatosteatosis in Mice

(2013) Ashley M. Miller et al.   PLoS One

Pro-Inflammatory Activated Kupffer Cells by Lipids Induce Hepatic NKT Cells Deficiency through Activation-Induced Cell Death

(2013) Tongfang Tang et al.   PLoS One

Macrophage-Induced Tumor Angiogenesis Is Regulated by the TSC2-mTOR Pathway

(2012) W. Chen et al.   CANCER RESEARCH

Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer

(2012) Alexander Pedroza-Gonzalez et al.   HEPATOLOGY

Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions

(2012) Yan Wu et al.   HEPATOLOGY

Distinct metabolic programs in activated T cells: opportunities for selective immunomodulation

(2012) Daniel R. Wahl et al.   IMMUNOLOGICAL REVIEWS

Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice

(2012) L. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocellular carcinoma and macrophage interaction induced tumor immunosuppressionviaTreg requires TLR4 signaling

(2012) Jing Yang   WORLD JOURNAL OF GASTROENTEROLOGY

AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2,

(2011) Coral Ho et al.   HEPATOLOGY

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

(2011) Katey J. Rayner et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

(2011) Katey J. Rayner et al.   NATURE

Rab18 Dynamics in Adipocytes in Relation to Lipogenesis, Lipolysis and Obesity

(2011) Marina R. Pulido et al.   PLoS One

FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase

(2010) Alaric Falcon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Fatty acid synthase as a potential therapeutic target in cancer

(2010) Richard Flavin et al.   Future Oncology

Lipid accumulation and dendritic cell dysfunction in cancer

(2010) Donna L Herber et al.   NATURE MEDICINE

miR-33 links SREBP-2 induction to repression of sterol transporters

(2010) T. J. Marquart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence of aberrant lipid metabolism in hepatitis C and hepatocellular carcinoma

(2010) Jian-Min Wu et al.   HPB

Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics

(2010) Deborah L. Diamond et al.   PLoS Pathogens

Kupffer Cell Suppression of CD8+ T Cells in Human Hepatocellular Carcinoma Is Mediated by B7-H1/Programmed Death-1 Interactions

(2009) K. Wu et al.   CANCER RESEARCH

High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection

(2008) Tong Ding et al.   HUMAN PATHOLOGY

Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma

(2008) Taro Yamashita et al.   JOURNAL OF HEPATOLOGY