Control of T-Cell Activation and Signaling by Amino-Acid Catabolizing Enzymes

mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions

(2020) Hongling Huang et al.   IMMUNOLOGICAL REVIEWS

Myeloid-Derived Suppressor Cell-Derived Arginase-1 Oppositely Modulates IL-17A and IL-17F Through the ESR/STAT3 Pathway During Colitis in Mice

(2020) Zhanchuan Ma et al.   Frontiers in Immunology

IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression

(2020) Ahmed Sadik et al.   CELL

Taming the Sentinels: Microbiome-Derived Metabolites and Polarization of T Cells

(2020) Lukasz Wojciech et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endogenous Indole Pyruvate Pathway for Tryptophan Metabolism Mediated by IL4I1

(2020) Xia Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Arginase impedes the resolution of colitis by altering the microbiome and metabolome

(2020) Julia Baier et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

(2020) Yingjie Bian et al.   NATURE

Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation

(2020) Bruno Lamas et al.   Science Translational Medicine

Critical Neurotransmitters in the Neuroimmune Network

(2020) Thomas Wesley Hodo et al.   Frontiers in Immunology

IL4I1 Accelerates the Expansion of Effector CD8+ T Cells at the Expense of Memory Precursors by Increasing the Threshold of T-Cell Activation

(2020) Marie-Line Puiffe et al.   Frontiers in Immunology

Methionine is a metabolic dependency of tumor-initiating cells

(2019) Zhenxun Wang et al.   NATURE MEDICINE

Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care

(2019) Anna Tarocco et al.   Cell Death & Disease

Antigen receptor control of methionine metabolism in T cells

(2019) Linda V Sinclair et al.   eLife

The IL4I1 Enzyme: A New Player in the Immunosuppressive Tumor Microenvironment

(2019) Valérie Molinier-Frenkel et al.   Cells

T Cell Activation Depends on Extracellular Alanine

(2019) Noga Ron-Harel et al.   Cell Reports

Efficacy and toxicity of reduced vs. standard dose pegylated asparaginase in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia

(2019) Benjamin A. Derman et al.   LEUKEMIA & LYMPHOMA

Serotonin decreases the production of Th1/Th17 cytokines and elevates the frequency of regulatory CD4+ T-cell subsets in multiple sclerosis patients

(2018) Priscila M. Sacramento et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Nitric Oxide Signaling in T Cell-Mediated Immunity

(2018) Almudena García-Ortiz et al.   TRENDS IN MOLECULAR MEDICINE

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

(2018) Jing Gao et al.   Frontiers in Cellular and Infection Microbiology

Inflammation drives nitric oxide synthase 2 expression by γδ T cells and affects the balance between melanoma and vitiligo associated melanoma

(2018) Laetitia Douguet et al.   OncoImmunology

Glutathione Primes T Cell Metabolism for Inflammation

(2017) Tak W. Mak et al.   IMMUNITY

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells

(2017) Giada Mondanelli et al.   IMMUNITY

Indoleamine 2,3-dioxygenase regulates T cell activity through Vav1/Rac pathway

(2017) Runmei Li et al.   MOLECULAR IMMUNOLOGY

TFH-derived dopamine accelerates productive synapses in germinal centres

(2017) Ilenia Papa et al.   NATURE

The role of autophagy in asparaginase-induced immune suppression of macrophages

(2017) Ping Song et al.   Cell Death & Disease

Amino-acid transporters in T-cell activation and differentiation

(2017) Wenkai Ren et al.   Cell Death & Disease

eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1

(2017) Almudena García-Ortiz et al.   PLOS BIOLOGY

The IDO–AhR Axis Controls Th17/Treg Immunity in a Pulmonary Model of Fungal Infection

(2017) Eliseu Frank de Araújo et al.   Frontiers in Immunology

Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression

(2017) Anke Werner et al.   Frontiers in Immunology

Anti-inflammatory effects of melatonin in multiple sclerosis

(2016) Mauricio F. Farez et al.   BIOESSAYS

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Dopamine Receptor D3 Signaling on CD4+T Cells Favors Th1- and Th17-Mediated Immunity

(2016) Francisco Contreras et al.   JOURNAL OF IMMUNOLOGY

Arginase-1–dependent promotion of T H 17 differentiation and disease progression by MDSCs in systemic lupus erythematosus

(2016) Hao Wu et al.   Science Translational Medicine

Nitric oxide synthase 2 is involved in the pro-tumorigenic potential of γδ17 T cells in melanoma

(2016) Laetitia Douguet et al.   OncoImmunology

Nitric Oxide Synthase 2 Improves Proliferation and Glycolysis of Peripheral γδ T Cells

(2016) Laetitia Douguet et al.   PLoS One

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

(2015) S.M. O’Mahony et al.   BEHAVIOURAL BRAIN RESEARCH

Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs

(2015) Soranobu Ninomiya et al.   BLOOD

Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses

(2015) Mauricio F. Farez et al.   CELL

Induced arginine transport via cationic amino acid transporter-1 is necessary for human T-cell proliferation

(2015) Anke Werner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The immunosuppressive enzyme IL4I1 promotes FoxP3+regulatory T lymphocyte differentiation

(2015) Céline Cousin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Alterations of the immunosuppressive IL4I1 enzyme activity induced by naturally occurring SNP/mutations

(2015) V Molinier-Frenkel et al.   GENES AND IMMUNITY

Asparagine deprivation mediated by Salmonella asparaginase causes suppression of activation-induced T cell metabolic reprogramming

(2015) AnnMarie Torres et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Indoleamine 2,3-dioxygenase downregulates T-cell receptor complex ζ-chain and c-Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T-cells

(2015) THEODOROS ELEFTHERIADIS et al.   Molecular Medicine Reports

Enhanced calcium responses to serotonin receptor stimulation in T-lymphocytes from schizophrenic patients – A pilot study

(2015) J. Genius et al.   NEUROSCIENCE LETTERS

Ghrelin Inhibits the Differentiation of T Helper 17 Cells through mTOR/STAT3 Signaling Pathway

(2015) Yanhui Xu et al.   PLoS One

Human CD4+ T cells require exogenous cystine for glutathione and DNA synthesis

(2015) Trine B. Levring et al.   Oncotarget

L-Asparaginase delivered by Salmonella typhimurium suppresses solid tumors

(2015) Kwangsoo Kim et al.   Molecular Therapy-Oncolytics

IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production

(2015) Yinpu Yue et al.   PLoS One

L-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

(2014) M. Fletcher et al.   CANCER RESEARCH

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

Expression of Dopaminergic Receptors on Human CD4+ T Lymphocytes: Flow Cytometric Analysis of Naive and Memory Subsets and Relevance for the Neuroimmunology of Neurodegenerative Disease

(2014) Natasa Kustrimovic et al.   Journal of Neuroimmune Pharmacology

Inducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cells

(2014) Ankur S Saini et al.   NATURE IMMUNOLOGY

T cell–derived inducible nitric oxide synthase switches off TH17 cell differentiation

(2013) Jianjun Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling

(2013) Nataša Obermajer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LAT1 Is a Critical Transporter of Essential Amino Acids for Immune Reactions in Activated Human T Cells

(2013) K. Hayashi et al.   JOURNAL OF IMMUNOLOGY

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Indoleamine 2,3-Dioxygenase and Metabolites Protect Murine Lung Allografts and Impair the Calcium Mobilization of T Cells

(2012) Khadija Iken et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

Activated human CD4+ T cells express transporters for both cysteine and cystine

(2012) Trine Bøegh Levring et al.   Scientific Reports

IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan

(2012) Richard Metz et al.   OncoImmunology

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

(2011) Maria T Pallotta et al.   NATURE IMMUNOLOGY

Serotonin-Mediated Tuning of Human Helper T Cell Responsiveness to the Chemokine CXCL12

(2011) Elena Magrini et al.   PLoS One

Regulation of type 17 helper T-cell function by nitric oxide during inflammation

(2011) W. Niedbala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IDO inhibits T-cell function through suppressing Vav1 expression and activation

(2010) Runmei Li et al.   CANCER BIOLOGY & THERAPY

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

Dichotomy between factors inducing the immunosuppressive enzyme IL-4-induced gene 1 (IL4I1) in B lymphocytes and mononuclear phagocytes

(2010) Jeanine Marquet et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

Melatonin Protects CD4+ T Cells from Activation-Induced Cell Death by Blocking NFAT-Mediated CD95 Ligand Upregulation

(2010) A. M. d. C. Pedrosa et al.   JOURNAL OF IMMUNOLOGY

L-Arginine Deprivation Regulates Cyclin D3 mRNA Stability in Human T Cells by Controlling HuR Expression

(2010) P. C. Rodriguez et al.   JOURNAL OF IMMUNOLOGY

Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

(2010) E. L. Carr et al.   JOURNAL OF IMMUNOLOGY

Protein Kinase C-  Mediates Negative Feedback on Regulatory T Cell Function

(2010) A. Zanin-Zhorov et al.   SCIENCE

Divergent effects of norepinephrine, dopamine and substance P on the activation, differentiation and effector functions of human cytotoxic T lymphocytes

(2009) Carina Strell et al.   BMC IMMUNOLOGY

Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes

(2009) Paulo C. Rodriguez et al.   CANCER RESEARCH

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Anergic T Cells Are Metabolically Anergic

(2009) Y. Zheng et al.   JOURNAL OF IMMUNOLOGY

CXCR4 Expression Functionally Discriminates Centroblasts versus Centrocytes within Human Germinal Center B Cells

(2009) G. Caron et al.   JOURNAL OF IMMUNOLOGY

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

(2009) B. Baban et al.   JOURNAL OF IMMUNOLOGY

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA