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Title
KDM6 Demethylases and Their Roles in Human Cancers
Authors
Keywords
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Journal
Frontiers in Oncology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-12-07
DOI
10.3389/fonc.2021.779918
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Note: Only part of the references are listed.- KDM6B is an androgen regulated gene and plays oncogenic roles by demethylating H3K27me3 at cyclin D1 promoter in prostate cancer
- (2021) Zhi Cao et al. Cell Death & Disease
- Tumor-associated mesenchymal stem cells promote hepatocellular carcinoma metastasis via a DNM3OS/KDM6B/TIAM1 axis
- (2021) Wei Wang et al. CANCER LETTERS
- Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction
- (2020) Kohei Kobatake et al. CLINICAL CANCER RESEARCH
- Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism
- (2020) Adam P. Cribbs et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Knockdown of UTX/KDM6A Enriches Precursor Cell Populations in Urothelial Cell Cultures and Cell Lines
- (2020) Alexander Lang et al. Cancers
- Wnt/β-catenin signaling contributes to prostate cancer heterogeneity through reciprocal suppression of H3K27 trimethylation
- (2020) Fan Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness
- (2020) Haiquan Lu et al. JOURNAL OF CLINICAL INVESTIGATION
- KDM6A suppresses hepatocellular carcinoma cell proliferation by negatively regulating the TGF‑β/SMAD signaling pathway
- (2020) Yuan Li et al. Experimental and Therapeutic Medicine
- Study of the Female Sex Survival Advantage in Melanoma—A Focus on X-Linked Epigenetic Regulators and Immune Responses in Two Cohorts
- (2020) Abdullah Al Emran et al. Cancers
- Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death
- (2020) Lucia Cottone et al. CANCER RESEARCH
- X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis
- (2020) Rossella Tricarico et al. CLINICAL CANCER RESEARCH
- Histone 3 lysine-27 demethylase KDM6A coordinates with KMT2B to play an oncogenic role in NSCLC by regulating H3K4me3
- (2020) Xuejiao Leng et al. ONCOGENE
- Loss of UTX/KDM6A and the activation of FGFR3 converge to regulate differentiation gene-expression programs in bladder cancer
- (2020) Douglas Barrows et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Macroscopic somatic clonal expansion in morphologically normal human urothelium
- (2020) Ruoyan Li et al. SCIENCE
- EZH2 and KDM6B Expressions Are Associated with Specific Epigenetic Signatures during EMT in Non Small Cell Lung Carcinomas
- (2020) Camille Lachat et al. Cancers
- Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma
- (2020) Jiaqing Yi et al. CANCER LETTERS
- MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia
- (2019) Mayukh Biswas et al. FASEB JOURNAL
- The Histone Demethylase UTX/KDM6A in Cancer: Progress and Puzzles
- (2019) Wolfgang A. Schulz et al. INTERNATIONAL JOURNAL OF CANCER
- Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation
- (2019) Liqun Yang et al. Oncogenesis
- Comprehensive profiling of JMJD3 in gastric cancer and its influence on patient survival
- (2019) Zhenyu Xu et al. Scientific Reports
- Hypoxia induces rapid changes to histone methylation and reprograms chromatin
- (2019) Michael Batie et al. SCIENCE
- Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
- (2019) Abhishek A. Chakraborty et al. SCIENCE
- Histone modifiers are oxygen sensors
- (2019) Paolo Gallipoli et al. SCIENCE
- Inhibition of EZH2 induces NK cell-mediated differentiation and death in muscle-invasive bladder cancer
- (2019) Swathi Ramakrishnan et al. CELL DEATH AND DIFFERENTIATION
- UTX Mutations in Human Cancer
- (2019) Lu Wang et al. CANCER CELL
- Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis
- (2019) Cates Mallaney et al. LEUKEMIA
- Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation
- (2019) Iveta Gažová et al. MOLECULAR GENETICS AND METABOLISM
- Contingencies of UTX/KDM6A Action in Urothelial Carcinoma
- (2019) Alexander Lang et al. Cancers
- The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism
- (2019) Soojeong Chang et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Inflammation and Cancer: Triggers, Mechanisms, and Consequences
- (2019) Florian R. Greten et al. IMMUNITY
- Loss of KDM6A confers drug resistance in acute myeloid leukemia
- (2019) Sophie M. Stief et al. LEUKEMIA
- Roles and regulation of histone methylation in animal development
- (2019) Ashwini Jambhekar et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma
- (2019) Allen S. Ho et al. JOURNAL OF CLINICAL INVESTIGATION
- The emerging role of epigenetic therapeutics in immuno-oncology
- (2019) Michael J. Topper et al. Nature Reviews Clinical Oncology
- The role and prospect of JMJD3 in stem cells and cancer
- (2019) Xiaojiao Yin et al. BIOMEDICINE & PHARMACOTHERAPY
- GATA3 recruits UTX for gene transcriptional activation to suppress metastasis of breast cancer
- (2019) Wenqian Yu et al. Cell Death & Disease
- Therapeutically targeting head and neck squamous cell carcinoma through synergistic inhibition of LSD1 and JMJD3 by TCP and GSK-J1
- (2019) Wei Zhang et al. BRITISH JOURNAL OF CANCER
- Inhibition of Histone Demethylases LSD1 and UTX Regulates ERα Signaling in Breast Cancer
- (2019) Rosaria Benedetti et al. Cancers
- Metformin directly targets the H3K27me3 demethylase KDM6A/UTX
- (2018) Elisabet Cuyàs et al. AGING CELL
- Inhibition of TRAF6 ubiquitin-ligase activity by PRDX1 leads to inhibition of NFKB activation and autophagy activation
- (2018) Yoon Min et al. Autophagy
- Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors
- (2018) Jaclyn Andricovich et al. CANCER CELL
- Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients
- (2018) Philipp A. Greif et al. CLINICAL CANCER RESEARCH
- Low HOX gene expression in PML-RARα-positive leukemia results from suppressed histone demethylation
- (2018) Katerina Rejlova et al. Epigenetics
- GATA3 as a master regulator and therapeutic target in ovarian high-grade serous carcinoma stem cells
- (2018) Hsiang-Ju Chen et al. INTERNATIONAL JOURNAL OF CANCER
- The Prognostic Significance of Histone Demethylase UTX in Esophageal Squamous Cell Carcinoma
- (2018) Shau-Hsuan Li et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells
- (2018) Adam Cribbs et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia
- (2018) Yunan Li et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B
- (2018) Dania Al Labban et al. JOURNAL OF CLINICAL INVESTIGATION
- KDM6B counteracts EZH2-mediated suppression of IGFBP5 to confer resistance to PI3K/AKT inhibitor treatment in breast cancer
- (2018) Wenyu Wang et al. MOLECULAR CANCER THERAPEUTICS
- UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs
- (2018) Malgorzata Gozdecka et al. NATURE GENETICS
- Contextual determinants of TGFβ action in development, immunity and cancer
- (2018) Charles J. David et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis
- (2018) Qibiao Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma
- (2018) Timothy L. Lochmann et al. Science Translational Medicine
- UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma
- (2018) Xiaoxi Li et al. Nature Communications
- A new metabolic gene signature in prostate cancer regulated by JMJD3 and EZH2
- (2018) Marine Daures et al. Oncotarget
- Targeting estrogen receptor beta (ERβ) for treatment of ovarian cancer: importance of KDM6B and SIRT1 for ERβ expression and functionality
- (2018) Giulia Pinton et al. Oncogenesis
- X chromosome protects against bladder cancer in females via aKDM6A-dependent epigenetic mechanism
- (2018) Satoshi Kaneko et al. Science Advances
- KDM6B promotes ovarian cancer cell migration and invasion by induced transforming growth factor-β1 expression
- (2018) Shumei Liang et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML
- (2018) Shan-He Yu et al. Nature Communications
- Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma
- (2018) François Audenet et al. CLINICAL CANCER RESEARCH
- Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality
- (2018) Shuichi Watanabe et al. INTERNATIONAL JOURNAL OF CANCER
- GSKJ4, an H3K27me3 demethylase inhibitor, effectively suppresses the breast cancer stem cells
- (2017) Ningning Yan et al. EXPERIMENTAL CELL RESEARCH
- Kdm6a and Kdm6b: Altered expression in malignant pleural mesothelioma
- (2017) Sian Cregan et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Loss of TET1 facilitates DLD1 colon cancer cell migration via H3K27me3-mediated down-regulation of E-cadherin
- (2017) Zhen Zhou et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Increased expression of the histone H3 lysine 4 methyltransferase MLL4 and the histone H3 lysine 27 demethylase UTX prolonging the overall survival of patients with glioblastoma and a methylated MGMT promoter
- (2017) Jinho Kim et al. JOURNAL OF NEUROSURGERY
- KDM6B modulates MAPK pathway mediating multiple myeloma cell growth and survival
- (2017) H Ohguchi et al. LEUKEMIA
- Multifunctional nanoparticles for co-delivery of paclitaxel and carboplatin against ovarian cancer by inactivating the JMJD3-HER2 axis
- (2017) Jingxin Mo et al. Nanoscale
- L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
- (2017) Andrew M Intlekofer et al. Nature Chemical Biology
- UTX promotes hormonally responsive breast carcinogenesis through feed-forward transcription regulation with estrogen receptor
- (2017) G Xie et al. ONCOGENE
- Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2
- (2017) Lian Dee Ler et al. Science Translational Medicine
- Long noncoding RNA HOTAIR promotes metastasis of renal cell carcinoma by up-regulating histone H3K27 demethylase JMJD3
- (2017) Ming Xia et al. Oncotarget
- JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activity
- (2017) Jing Xun et al. Oncotarget
- The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition
- (2017) Joseph H. Taube et al. Oncotarget
- Inhibitor of H3K27 demethylase JMJD3/UTX GSK-J4 is a potential therapeutic option for castration resistant prostate cancer
- (2017) Viacheslav M. Morozov et al. Oncotarget
- The pharmacological role of histone demethylase JMJD3 inhibitor GSK-J4 on glioma cells
- (2017) Aixia Sui et al. Oncotarget
- UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition
- (2017) Teresa Ezponda et al. Cell Reports
- KDM6A addiction of cervical carcinoma cell lines is triggered by E7 and mediated by p21CIP1 suppression of replication stress
- (2017) David R. Soto et al. PLoS Pathogens
- Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy
- (2017) Roberta Mazzone et al. Clinical Epigenetics
- Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3
- (2017) Maureen M. Sherry-Lynes et al. PLoS One
- H3K27 Demethylase JMJD3 Employs the NF- B and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis
- (2016) W.-Y. Park et al. CANCER RESEARCH
- Aberrant JMJD3 Expression Upregulates Slug to Promote Migration, Invasion, and Stem Cell–Like Behaviors in Hepatocellular Carcinoma
- (2016) Bo Tang et al. CANCER RESEARCH
- Histone demethylases in physiology and cancer: a tale of two enzymes, JMJD3 and UTX
- (2016) Kelly Marie Arcipowski et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia
- (2016) Aissa Benyoucef et al. GENES & DEVELOPMENT
- Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs
- (2016) Rohit Mathur et al. HAEMATOLOGICA
- Epigenetic regulation of E-cadherin expression by the histone demethylase UTX in colon cancer cells
- (2016) Lin Zha et al. MEDICAL ONCOLOGY
- Genomic analyses identify molecular subtypes of pancreatic cancer
- (2016) Peter Bailey et al. NATURE
- Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation
- (2016) Min Pan et al. NATURE CELL BIOLOGY
- Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma
- (2016) Takahiro Kodama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation
- (2016) A. Dutta et al. SCIENCE
- JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms
- (2016) Yan Zhang et al. Oncotarget
- Histone Lysine Demethylase Inhibitors
- (2016) Ashwini Jambhekar et al. Cold Spring Harbor Perspectives in Medicine
- Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs
- (2016) Rohit Mathur et al. HAEMATOLOGICA
- The Prognostic Significance of Histone Lysine Demethylase JMJD3/KDM6B in Colorectal Cancer
- (2015) Ryuma Tokunaga et al. ANNALS OF SURGICAL ONCOLOGY
- PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer
- (2015) Nisha Nagarsheth et al. CANCER RESEARCH
- Hypoxia Induces Production of L-2-Hydroxyglutarate
- (2015) Andrew M. Intlekofer et al. Cell Metabolism
- The NASH drug dash
- (2015) Kelly Rae Chi NATURE REVIEWS DRUG DISCOVERY
- The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia
- (2014) Joni Van der Meulen et al. BLOOD
- UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
- (2014) Jae-Hwan Kim et al. CANCER RESEARCH
- Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBPα
- (2014) Keisuke Yamamoto et al. CARCINOGENESIS
- The H3K27me3 demethylase UTX in normal development and disease
- (2014) Joni Van der Meulen et al. Epigenetics
- Human UTY(KDM6C) Is a Male-specificNϵ-Methyl Lysyl Demethylase
- (2014) Louise J. Walport et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of UTX in Retinoic Acid Receptor-Mediated Gene Regulation in Leukemia
- (2014) L. Rocha-Viegas et al. MOLECULAR AND CELLULAR BIOLOGY
- Inhibition of demethylases by GSK-J1/J4
- (2014) Bo Heinemann et al. NATURE
- The roles of Jumonji-type oxygenases in human disease
- (2014) Catrine Johansson et al. Epigenomics
- Androgen Receptor Antagonists in Castration-Resistant Prostate Cancer
- (2013) Dana Rathkopf et al. CANCER JOURNAL
- The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia
- (2013) Piotr Przanowski et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Histone lysine demethylases as targets for anticancer therapy
- (2013) Jonas W. Højfeldt et al. NATURE REVIEWS DRUG DISCOVERY
- Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines
- (2013) M. E. McLaughlin-Drubin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
- (2013) J. Gao et al. Science Signaling
- Cancer Epigenetics: From Mechanism to Therapy
- (2012) Mark A. Dawson et al. CELL
- Histone Demethylase KDM6B Promotes Epithelial-Mesenchymal Transition
- (2012) Sivakumar Ramadoss et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
- (2012) Laurens Kruidenier et al. NATURE
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development
- (2012) Karl B. Shpargel et al. PLoS Genetics
- Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A
- (2011) T. Sengoku et al. GENES & DEVELOPMENT
- KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells
- (2011) Fábio Pereira et al. HUMAN MOLECULAR GENETICS
- The H3K27me3 demethylase, KDM6B, is induced by Epstein–Barr virus and over-expressed in Hodgkin's Lymphoma
- (2011) J A Anderton et al. ONCOGENE
- The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase
- (2010) Minoru Terashima et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The H3K27me3 Demethylase dUTX Is a Suppressor of Notch- and Rb-Dependent Tumors in Drosophila
- (2010) H. M. Herz et al. MOLECULAR AND CELLULAR BIOLOGY
- Jmjd3 and UTX Play a Demethylase-Independent Role in Chromatin Remodeling to Regulate T-Box Family Member-Dependent Gene Expression
- (2010) Sara A. Miller et al. MOLECULAR CELL
- Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS
- (2009) M. Barradas et al. GENES & DEVELOPMENT
- The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence
- (2009) K. Agger et al. GENES & DEVELOPMENT
- Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination
- (2009) T. Fei et al. GENOME RESEARCH
- Regulation of hypoxia-inducible factor-1α by NF-κB
- (2008) Patrick van Uden et al. BIOCHEMICAL JOURNAL
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