Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression

(2019) Yu Cao et al.   Nature Communications

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

(2019) Feven Tameire et al.   NATURE CELL BIOLOGY

Upregulation of H3K27 Demethylase KDM6 During Respiratory Syncytial Virus Infection Enhances Proinflammatory Responses and Immunopathology

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Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells

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Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28

(2018) Yu Jiang et al.   Nature Communications

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TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy

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New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice

(2017) Chie Naruse et al.   FASEB JOURNAL

The mitochondrial unfolded protein response: Signaling from the powerhouse

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Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis

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Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

(2017) Tao Xu et al.   NATURE

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Advances and challenges in understanding histone demethylase biology

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The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs

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Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity

(2015) Jellert T. Gaublomme et al.   CELL

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

(2015) Chao Wang et al.   CELL

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

The Methylcytosine Dioxygenase Tet2 Promotes DNA Demethylation and Activation of Cytokine Gene Expression in T Cells

(2015) Kenji Ichiyama et al.   IMMUNITY

JMJD3 as an epigenetic regulator in development and disease

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Transcriptional regulation of T cell metabolism

(2015) Kenneth P. Hough et al.   MOLECULAR IMMUNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses

(2015) Ariane Hammitzsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation

(2015) Zhi Liu et al.   Journal of Molecular Cell Biology

Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation

(2015) Sugata Manna et al.   Nature Communications

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

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Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

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Pharmacologic Inhibition of ROR t Regulates Th17 Signature Gene Expression and Suppresses Cutaneous Inflammation In Vivo

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mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

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Inhibition of demethylases by GSK-J1/J4

(2014) Bo Heinemann et al.   NATURE

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Gene Expression during the Generation and Activation of Mouse Neutrophils: Implication of Novel Functional and Regulatory Pathways

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Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation

(2014) Qingtian Li et al.   Nature Communications

Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome

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KDM6 Demethylase Independent Loss of Histone H3 Lysine 27 Trimethylation during Early Embryonic Development

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Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation

(2013) Shigenori Nagai et al.   Annals of the New York Academy of Sciences

Shared care or nursing consultations as an alternative to rheumatologist follow-up for rheumatoid arthritis outpatients with low disease activity—patient outcomes from a 2-year, randomised controlled trial

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featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

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Influence of Metabolism on Epigenetics and Disease

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Metabolic Pathways in Immune Cell Activation and Quiescence

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BET bromodomain inhibition suppresses TH17-mediated pathology

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Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome CD34+ cells

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viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

(2013) El-ad David Amir et al.   NATURE BIOTECHNOLOGY

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Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

Small molecule inhibitors of RORγt: Targeting Th17 cells and other applications

(2012) Jun R. Huh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

Inflammasomes in carcinogenesis and anticancer immune responses

(2012) Laurence Zitvogel et al.   NATURE IMMUNOLOGY

A two-way street: reciprocal regulation of metabolism and signalling

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X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

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The H3K27 Demethylase JMJD3 Is Required for Maintenance of the Embryonic Respiratory Neuronal Network, Neonatal Breathing, and Survival

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The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Helper T-cell differentiation and plasticity: insights from epigenetics

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Human Th1 and Th17 Cells Exhibit Epigenetic Stability at Signature Cytokine and Transcription Factor Loci

(2011) C. J. Cohen et al.   JOURNAL OF IMMUNOLOGY

Jmjd3 and UTX Play a Demethylase-Independent Role in Chromatin Remodeling to Regulate T-Box Family Member-Dependent Gene Expression

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The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Epigenetic regulation of the alternatively activated macrophage phenotype

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Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

(2009) Gang Wei et al.   IMMUNITY

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

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