Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality

Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors

(2018) Jaclyn Andricovich et al.   CANCER CELL

ARID2 modulates DNA damage response in human hepatocellular carcinoma cells

(2017) Atsushi Oba et al.   JOURNAL OF HEPATOLOGY

A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription

(2017) Shu-Ping Wang et al.   MOLECULAR CELL

Integrative clinical genomics of metastatic cancer

(2017) Dan R. Robinson et al.   NATURE

UTX promotes hormonally responsive breast carcinogenesis through feed-forward transcription regulation with estrogen receptor

(2017) G Xie et al.   ONCOGENE

Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2

(2017) Lian Dee Ler et al.   Science Translational Medicine

Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of CDKN1A

(2017) Andrea Halaburková et al.   Clinical Epigenetics

Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma

(2016) Rekin’s Janky et al.   BMC CANCER

Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?

(2016) Elisabeth Hessmann et al.   GUT

Pancreatic cancer

(2016) Terumi Kamisawa et al.   LANCET

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Phase I trial of vorinostat added to chemoradiation with capecitabine in pancreatic cancer

(2016) Emily Chan et al.   RADIOTHERAPY AND ONCOLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway

(2012) Wei Jiang et al.   CELL RESEARCH

Identification of Pancreatic Cancer Stem Cells and Selective Toxicity of Chemotherapeutic Agents

(2012) Rama Adikrisna et al.   GASTROENTEROLOGY

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming

(2012) Abed AlFatah Mansour et al.   NATURE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A

(2011) A. M. Jankowska et al.   BLOOD

Cancer statistics, 2011

(2011) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

TXNIP (VDUP-1, TBP-2): A major redox regulator commonly suppressed in cancer by epigenetic mechanisms

(2011) Jianbiao Zhou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

Lysyl oxidase: a potential target for cancer therapy

(2010) Siddikuzzaman et al.   INFLAMMOPHARMACOLOGY

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS