UTX promotes hormonally responsive breast carcinogenesis through feed-forward transcription regulation with estrogen receptor

UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia

(2016) Aissa Benyoucef et al.   GENES & DEVELOPMENT

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients

(2016) A. Marcell Szász et al.   Oncotarget

Molecular Pathways: Targeting the CXCR4-CXCL12 Axis--Untapped Potential in the Tumor Microenvironment

(2015) S. Scala   CLINICAL CANCER RESEARCH

UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1

(2015) H.-J. Choi et al.   EMBO REPORTS

CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice

(2015) Yunching Chen et al.   HEPATOLOGY

Challenges in the management of advanced, ER-positive, HER2-negative breast cancer

(2015) Christopher D. Hart et al.   Nature Reviews Clinical Oncology

ASXL2 promotes proliferation of breast cancer cells by linking ERα to histone methylation

(2015) U-H Park et al.   ONCOGENE

CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks

(2015) F Guo et al.   ONCOGENE

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

(2014) Joni Van der Meulen et al.   BLOOD

UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells

(2014) Jae-Hwan Kim et al.   CANCER RESEARCH

Molecular Pathways: Deregulation of Histone H3 Lysine 27 Methylation in Cancer--Different Paths, Same Destination

(2014) T. Ezponda et al.   CLINICAL CANCER RESEARCH

SDF-1/CXCR7 Axis Enhances Ovarian Cancer Cell Invasion by MMP-9 Expression Through p38 MAPK Pathway

(2014) Yuecheng Yu et al.   DNA AND CELL BIOLOGY

The H3K27me3 demethylase UTX in normal development and disease

(2014) Joni Van der Meulen et al.   Epigenetics

Role of UTX in Retinoic Acid Receptor-Mediated Gene Regulation in Leukemia

(2014) L. Rocha-Viegas et al.   MOLECULAR AND CELLULAR BIOLOGY

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

(2014) Panagiotis Ntziachristos et al.   NATURE

Enhancer biology and enhanceropathies

(2014) Edwin Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer

(2014) Mark A. Wade et al.   NUCLEIC ACIDS RESEARCH

Genome-wide pathway analysis of breast cancer

(2014) Young Ho Lee et al.   TUMOR BIOLOGY

Metastasis Dormancy in Estrogen Receptor-Positive Breast Cancer

(2013) X. H.- F. Zhang et al.   CLINICAL CANCER RESEARCH

Variable steroid receptor responses: Intrinsically disordered AF1 is the key

(2013) S. Stoney Simons et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor

(2013) Hisham Mohammed et al.   Cell Reports

Estrogen and Cancer

(2012) Jing Liang et al.   Annual Review of Physiology

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

(2012) H. Thorvaldsdottir et al.   BRIEFINGS IN BIOINFORMATICS

H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic geneBCL2determines ERα ligand dependency

(2011) Amy Svotelis et al.   EMBO JOURNAL

Oestrogen receptor-co-factor-chromatin specificity in the transcriptional regulation of breast cancer

(2011) Wilbert Zwart et al.   EMBO JOURNAL

Navigating Breast Cancer: Axon Guidance Molecules as Breast Cancer Tumor Suppressors and Oncogenes

(2011) Gwyndolen C. Harburg et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

GOBO: Gene Expression-Based Outcome for Breast Cancer Online

(2011) Markus Ringnér et al.   PLoS One

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis

(2011) L. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cistrome: an integrative platform for transcriptional regulation studies

(2011) Tao Liu et al.   GENOME BIOLOGY

Cytokine Receptor CXCR4 Mediates Estrogen-Independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer

(2010) Lyndsay V. Rhodes et al.   CANCER RESEARCH

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

(2010) Qihuang Jin et al.   EMBO JOURNAL

The histone demethylase UTX enables RB-dependent cell fate control

(2010) J. K. Wang et al.   GENES & DEVELOPMENT

KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development

(2010) Y.-i. Tsukada et al.   GENES & DEVELOPMENT

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS