In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 115, Issue 17, Pages E3978-E3986
Publisher
Proceedings of the National Academy of Sciences
Online
2018-04-10
DOI
10.1073/pnas.1716589115
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2
- (2017) Lian Dee Ler et al. Science Translational Medicine
- Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer
- (2016) Michela Serresi et al. CANCER CELL
- The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells
- (2016) Semir Beyaz et al. NATURE IMMUNOLOGY
- Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer
- (2016) H. Zhang et al. Cancer Discovery
- LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response
- (2015) Fuming Li et al. CANCER CELL
- A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC
- (2015) Helai P. Mohammad et al. CANCER CELL
- Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis
- (2015) Sidi Chen et al. CELL
- EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors
- (2015) Christine M. Fillmore et al. NATURE
- The prognostic landscape of genes and infiltrating immune cells across human cancers
- (2015) Andrew J Gentles et al. NATURE MEDICINE
- The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia
- (2014) Joni Van der Meulen et al. BLOOD
- Cancer statistics, 2014
- (2014) Rebecca Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
- (2014) Randall J. Platt et al. CELL
- Comprehensive molecular profiling of lung adenocarcinoma
- (2014) Eric A. Collisson et al. NATURE
- Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia
- (2014) Panagiotis Ntziachristos et al. NATURE
- Rapid modelling of cooperating genetic events in cancer through somatic genome editing
- (2014) Francisco J. Sánchez-Rivera et al. NATURE
- CRISPR-mediated direct mutation of cancer genes in the mouse liver
- (2014) Wen Xue et al. NATURE
- NGSUtils: a software suite for analyzing and manipulating next-generation sequencing datasets
- (2013) Marcus R. Breese et al. BIOINFORMATICS
- Nkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma
- (2013) Eric L. Snyder et al. MOLECULAR CELL
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Transcriptional regulation by Polycomb group proteins
- (2013) Luciano Di Croce et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
- (2013) Ophir Shalem et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
- (2012) Marcin Imielinski et al. CELL
- Identification of RET gene fusion by exon array analyses in “pan-negative” lung cancer from never smokers
- (2012) Fei Li et al. CELL RESEARCH
- LKB1-AMPK axis revisited
- (2012) Filippos Kottakis et al. CELL RESEARCH
- AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
- (2012) Sang-Min Jeon et al. NATURE
- Polycomb repressive complex 2 is required for MLL-AF9 leukemia
- (2012) T. Neff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity
- (2012) C. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fast and accurate long-read alignment with Burrows–Wheeler transform
- (2010) Heng Li et al. BIOINFORMATICS
- The histone demethylase UTX enables RB-dependent cell fate control
- (2010) J. K. Wang et al. GENES & DEVELOPMENT
- Deregulation of H3K27 methylation in cancer
- (2010) Eva Martinez-Garcia et al. NATURE GENETICS
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
- (2009) Gijs van Haaften et al. NATURE GENETICS
- Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase
- (2009) Michel DuPage et al. Nature Protocols
- Gene expression–based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study
- (2008) Kerby Shedden et al. NATURE MEDICINE
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started