Contingencies of UTX/KDM6A Action in Urothelial Carcinoma

The Histone Demethylase UTX/KDM6A in Cancer: Progress and Puzzles

(2019) Wolfgang A. Schulz et al.   INTERNATIONAL JOURNAL OF CANCER

UTX Mutations in Human Cancer

(2019) Lu Wang et al.   CANCER CELL

Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors

(2018) Jaclyn Andricovich et al.   CANCER CELL

UTX – moonlighting in the cytoplasm?

(2018) Ralf Wiedemuth et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs

(2018) Malgorzata Gozdecka et al.   NATURE GENETICS

Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin

(2018) Agnieszka Bochyńska et al.   Cells

Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

(2018) A. Gordon Robertson et al.   CELL

Mutational analysis of 472 urothelial carcinoma across grades and anatomic sites

(2018) Amin H Nassar et al.   CLINICAL CANCER RESEARCH

NLSdb—major update for database of nuclear localization signals and nuclear export signals

(2017) Michael Bernhofer et al.   NUCLEIC ACIDS RESEARCH

UTX promotes hormonally responsive breast carcinogenesis through feed-forward transcription regulation with estrogen receptor

(2017) G Xie et al.   ONCOGENE

Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2

(2017) Lian Dee Ler et al.   Science Translational Medicine

UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia

(2016) Aissa Benyoucef et al.   GENES & DEVELOPMENT

Inhibition of Class I Histone Deacetylases 1 and 2 Promotes Urothelial Carcinoma Cell Death by Various Mechanisms

(2016) M. Pinkerneil et al.   MOLECULAR CANCER THERAPEUTICS

Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer

(2016) Jinwoo Ahn et al.   Oncotarget

FOXA1, GATA3 and PPARɣ Cooperate to Drive Luminal Subtype in Bladder Cancer: A Molecular Analysis of Established Human Cell Lines

(2016) Joshua I. Warrick et al.   Scientific Reports

Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol

(2015) Constanze Wiek et al.   BIOCHEMICAL JOURNAL

The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells

(2015) Judith Heubach et al.   Molecular Cancer

Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution

(2015) Eva M. Schmidt et al.   PLoS One

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

(2014) Joni Van der Meulen et al.   BLOOD

Concurrent Alterations in TERT, KDM6A, and the BRCA Pathway in Bladder Cancer

(2014) M. L. Nickerson et al.   CLINICAL CANCER RESEARCH

The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2

(2014) Ziming Li et al.   FEBS LETTERS

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

(2014) Panagiotis Ntziachristos et al.   NATURE

The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis

(2013) A Hongjun Wang et al.   EMBO JOURNAL

Quantitative Dissection and Stoichiometry Determination of the Human SET1/MLL Histone Methyltransferase Complexes

(2013) R. van Nuland et al.   MOLECULAR AND CELLULAR BIOLOGY

A Cell of Origin Gene Signature Indicates Human Bladder Cancer Has Distinct Cellular Progenitors

(2013) Garrett M. Dancik et al.   STEM CELLS